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Expanded ILC2s in human infant intestines promote tissue growth

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Expanded ILC2s in human infant intestines promote tissue growth. / Möller, Kimberly J; Wegner, Lucy H M; Malsy, Jakob; Baumdick, Martin E; Borggrewe, Malte; Jordan-Paiz, Ana; Jung, Johannes M; Martrus, Glòria; Kretschmer, Paul; Sagebiel, Adrian F; Schreurs, Renée R C E; Hagen, Sven H; Burmester, Gunter; Clauditz, Till S; Pals, Steven T; Boettcher, Michael; Melling, Nathaniel; Sauter, Guido; Tomuschat, Christian; Königs, Ingo; Schumacher, Udo; Altfeld, Marcus; Bernink, Jochem H; Perez, Daniel; Reinshagen, Konard; Bunders, Madeleine J.

in: MUCOSAL IMMUNOL, Jahrgang 16, Nr. 4, 08.2023, S. 408-421.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Möller, KJ, Wegner, LHM, Malsy, J, Baumdick, ME, Borggrewe, M, Jordan-Paiz, A, Jung, JM, Martrus, G, Kretschmer, P, Sagebiel, AF, Schreurs, RRCE, Hagen, SH, Burmester, G, Clauditz, TS, Pals, ST, Boettcher, M, Melling, N, Sauter, G, Tomuschat, C, Königs, I, Schumacher, U, Altfeld, M, Bernink, JH, Perez, D, Reinshagen, K & Bunders, MJ 2023, 'Expanded ILC2s in human infant intestines promote tissue growth', MUCOSAL IMMUNOL, Jg. 16, Nr. 4, S. 408-421. https://doi.org/10.1016/j.mucimm.2023.04.004

APA

Möller, K. J., Wegner, L. H. M., Malsy, J., Baumdick, M. E., Borggrewe, M., Jordan-Paiz, A., Jung, J. M., Martrus, G., Kretschmer, P., Sagebiel, A. F., Schreurs, R. R. C. E., Hagen, S. H., Burmester, G., Clauditz, T. S., Pals, S. T., Boettcher, M., Melling, N., Sauter, G., Tomuschat, C., ... Bunders, M. J. (2023). Expanded ILC2s in human infant intestines promote tissue growth. MUCOSAL IMMUNOL, 16(4), 408-421. https://doi.org/10.1016/j.mucimm.2023.04.004

Vancouver

Möller KJ, Wegner LHM, Malsy J, Baumdick ME, Borggrewe M, Jordan-Paiz A et al. Expanded ILC2s in human infant intestines promote tissue growth. MUCOSAL IMMUNOL. 2023 Aug;16(4):408-421. https://doi.org/10.1016/j.mucimm.2023.04.004

Bibtex

@article{f7767e39db1043128ad07221641ca83d,
title = "Expanded ILC2s in human infant intestines promote tissue growth",
abstract = "Early life is characterized by extraordinary challenges, including rapid tissue growth and immune adaptation to foreign antigens after birth. During this developmental stage, infants have an increased risk of immune-mediated diseases. Here, we demonstrate that tissue-resident, interleukin (IL)-13- and IL-4-producing group 2 innate lymphoid cells (ILC2s) are enriched in human infant intestines compared to adult intestines. Organoid systems were employed to assess the role of infant intestinal ILC2s in intestinal development and showed that IL-13 and IL-4 increased epithelial cell proliferation and skewed cell differentiation toward secretory cells. IL-13 furthermore upregulated the production of mediators of type-2 immunity by infant intestinal epithelial cells, including vascular endothelial growth factor-A and IL-26, a chemoattractant for eosinophils. In line with these in vitro findings increased numbers of eosinophils were detected in vivo in infant intestines. Taken together, ILC2s are enriched in infant intestines and can support intestinal development while inducing an epithelial secretory response associated with type 2 immune-mediated diseases.",
keywords = "Adult, Humans, Infant, Immunity, Innate, Interleukin-13, Lymphocytes, Vascular Endothelial Growth Factor A, Interleukin-4, Intestines, Interleukin-33, Cytokines/metabolism",
author = "M{\"o}ller, {Kimberly J} and Wegner, {Lucy H M} and Jakob Malsy and Baumdick, {Martin E} and Malte Borggrewe and Ana Jordan-Paiz and Jung, {Johannes M} and Gl{\`o}ria Martrus and Paul Kretschmer and Sagebiel, {Adrian F} and Schreurs, {Ren{\'e}e R C E} and Hagen, {Sven H} and Gunter Burmester and Clauditz, {Till S} and Pals, {Steven T} and Michael Boettcher and Nathaniel Melling and Guido Sauter and Christian Tomuschat and Ingo K{\"o}nigs and Udo Schumacher and Marcus Altfeld and Bernink, {Jochem H} and Daniel Perez and Konard Reinshagen and Bunders, {Madeleine J}",
note = "Copyright {\textcopyright} 2023 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2023",
month = aug,
doi = "10.1016/j.mucimm.2023.04.004",
language = "English",
volume = "16",
pages = "408--421",
journal = "MUCOSAL IMMUNOL",
issn = "1933-0219",
publisher = "NATURE PUBLISHING GROUP",
number = "4",

}

RIS

TY - JOUR

T1 - Expanded ILC2s in human infant intestines promote tissue growth

AU - Möller, Kimberly J

AU - Wegner, Lucy H M

AU - Malsy, Jakob

AU - Baumdick, Martin E

AU - Borggrewe, Malte

AU - Jordan-Paiz, Ana

AU - Jung, Johannes M

AU - Martrus, Glòria

AU - Kretschmer, Paul

AU - Sagebiel, Adrian F

AU - Schreurs, Renée R C E

AU - Hagen, Sven H

AU - Burmester, Gunter

AU - Clauditz, Till S

AU - Pals, Steven T

AU - Boettcher, Michael

AU - Melling, Nathaniel

AU - Sauter, Guido

AU - Tomuschat, Christian

AU - Königs, Ingo

AU - Schumacher, Udo

AU - Altfeld, Marcus

AU - Bernink, Jochem H

AU - Perez, Daniel

AU - Reinshagen, Konard

AU - Bunders, Madeleine J

N1 - Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2023/8

Y1 - 2023/8

N2 - Early life is characterized by extraordinary challenges, including rapid tissue growth and immune adaptation to foreign antigens after birth. During this developmental stage, infants have an increased risk of immune-mediated diseases. Here, we demonstrate that tissue-resident, interleukin (IL)-13- and IL-4-producing group 2 innate lymphoid cells (ILC2s) are enriched in human infant intestines compared to adult intestines. Organoid systems were employed to assess the role of infant intestinal ILC2s in intestinal development and showed that IL-13 and IL-4 increased epithelial cell proliferation and skewed cell differentiation toward secretory cells. IL-13 furthermore upregulated the production of mediators of type-2 immunity by infant intestinal epithelial cells, including vascular endothelial growth factor-A and IL-26, a chemoattractant for eosinophils. In line with these in vitro findings increased numbers of eosinophils were detected in vivo in infant intestines. Taken together, ILC2s are enriched in infant intestines and can support intestinal development while inducing an epithelial secretory response associated with type 2 immune-mediated diseases.

AB - Early life is characterized by extraordinary challenges, including rapid tissue growth and immune adaptation to foreign antigens after birth. During this developmental stage, infants have an increased risk of immune-mediated diseases. Here, we demonstrate that tissue-resident, interleukin (IL)-13- and IL-4-producing group 2 innate lymphoid cells (ILC2s) are enriched in human infant intestines compared to adult intestines. Organoid systems were employed to assess the role of infant intestinal ILC2s in intestinal development and showed that IL-13 and IL-4 increased epithelial cell proliferation and skewed cell differentiation toward secretory cells. IL-13 furthermore upregulated the production of mediators of type-2 immunity by infant intestinal epithelial cells, including vascular endothelial growth factor-A and IL-26, a chemoattractant for eosinophils. In line with these in vitro findings increased numbers of eosinophils were detected in vivo in infant intestines. Taken together, ILC2s are enriched in infant intestines and can support intestinal development while inducing an epithelial secretory response associated with type 2 immune-mediated diseases.

KW - Adult

KW - Humans

KW - Infant

KW - Immunity, Innate

KW - Interleukin-13

KW - Lymphocytes

KW - Vascular Endothelial Growth Factor A

KW - Interleukin-4

KW - Intestines

KW - Interleukin-33

KW - Cytokines/metabolism

U2 - 10.1016/j.mucimm.2023.04.004

DO - 10.1016/j.mucimm.2023.04.004

M3 - SCORING: Journal article

C2 - 37121384

VL - 16

SP - 408

EP - 421

JO - MUCOSAL IMMUNOL

JF - MUCOSAL IMMUNOL

SN - 1933-0219

IS - 4

ER -