Evolution of paced QRS and QTc intervals in children with epicardial pacing leads

Maren Tomaske; Paul Harpes; Rene Prêtre; Ali Dodge-Khatami; Urs Bauersfeld

doi:10.1007/s00392-007-0558-0

Evolution of paced QRS and QTc intervals in children with epicardial pacing leads

Standard

Evolution of paced QRS and QTc intervals in children with epicardial pacing leads. / Tomaske, Maren; Harpes, Paul; Prêtre, Rene; Dodge-Khatami, Ali; Bauersfeld, Urs.

in: CLIN RES CARDIOL, Jahrgang 96, Nr. 11, 11.2007, S. 787-793.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Tomaske, M, Harpes, P, Prêtre, R, Dodge-Khatami, A & Bauersfeld, U 2007, 'Evolution of paced QRS and QTc intervals in children with epicardial pacing leads', CLIN RES CARDIOL, Jg. 96, Nr. 11, S. 787-793. https://doi.org/10.1007/s00392-007-0558-0

APA

Tomaske, M., Harpes, P., Prêtre, R., Dodge-Khatami, A., & Bauersfeld, U. (2007). Evolution of paced QRS and QTc intervals in children with epicardial pacing leads. CLIN RES CARDIOL, 96(11), 787-793. https://doi.org/10.1007/s00392-007-0558-0

Vancouver

Tomaske M, Harpes P, Prêtre R, Dodge-Khatami A, Bauersfeld U. Evolution of paced QRS and QTc intervals in children with epicardial pacing leads. CLIN RES CARDIOL. 2007 Nov;96(11):787-793. https://doi.org/10.1007/s00392-007-0558-0

Bibtex

@article{75c132e7f0284d77b81a246f367fb7be,

title = "Evolution of paced QRS and QTc intervals in children with epicardial pacing leads",

abstract = "AIMS: Permanent ventricular pacing in children is associated with ventricular dysfunction due to asynchronous activation. It is unclear whether paced QRS intervals increase disproportionately over time, which could potentially cause ventricular dysfunction.METHODS: A total of 52 children, with bipolar steroideluting epicardial leads implanted at a median age of 5.6 years (0.0-17.4), was analyzed and followed up to 12.2 years (median 3.7). Patients were subdivided in two groups: right (RV, n = 21) and left (LV, n = 31) ventricular pacing. To correct for age, standard deviation scores (Z-scores) for paced QRS and QTc intervals were calculated from published standard-ECG norm-values. As a measure for individual paced QRS and QTc interval changes, a regression slope coefficient (incline(i)) was calculated for each patient's course.RESULTS: Mean Z-scores for paced QRS intervals at first and last follow-up were 4.7 +/- 1.2 and 4.9 +/- 0.9 for group RV, 4.4 +/- 1.1 and 4.8 +/- 1.1 for group LV. Incline(i) of paced QRS (group RV: 0.038 [-0.27-0.12], group LV: 0.147 [-0.05-0.30]; p = 0.07) and QTc intervals (group RV: 0.026 [-0.08-0.06], group LV: 0.023 [-0.04-0.09]; p = 0.63) did not differ between both groups and indicated limited interval changes over time.CONCLUSION: Neither epicardial pacing of the right nor left ventricle caused disproportionate paced QRS or QTc interval increases over time. An age-related prolongation of the electrical activation unlikely causes ventricular dysfunction.",

keywords = "Adolescent, Age Factors, Cardiac Pacing, Artificial/adverse effects, Child, Child, Preschool, Drug-Eluting Stents, Electrocardiography, Electrodes, Implanted, Female, Follow-Up Studies, Glucocorticoids/therapeutic use, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Time Factors, Ventricular Dysfunction, Left/etiology",

author = "Maren Tomaske and Paul Harpes and Rene Pr{\^e}tre and Ali Dodge-Khatami and Urs Bauersfeld",

year = "2007",

month = nov,

doi = "10.1007/s00392-007-0558-0",

language = "English",

volume = "96",

pages = "787--793",

journal = "CLIN RES CARDIOL",

issn = "1861-0684",

publisher = "D. Steinkopff-Verlag",

number = "11",

}

RIS

TY - JOUR

T1 - Evolution of paced QRS and QTc intervals in children with epicardial pacing leads

AU - Tomaske, Maren

AU - Harpes, Paul

AU - Prêtre, Rene

AU - Dodge-Khatami, Ali

AU - Bauersfeld, Urs

PY - 2007/11

Y1 - 2007/11

N2 - AIMS: Permanent ventricular pacing in children is associated with ventricular dysfunction due to asynchronous activation. It is unclear whether paced QRS intervals increase disproportionately over time, which could potentially cause ventricular dysfunction.METHODS: A total of 52 children, with bipolar steroideluting epicardial leads implanted at a median age of 5.6 years (0.0-17.4), was analyzed and followed up to 12.2 years (median 3.7). Patients were subdivided in two groups: right (RV, n = 21) and left (LV, n = 31) ventricular pacing. To correct for age, standard deviation scores (Z-scores) for paced QRS and QTc intervals were calculated from published standard-ECG norm-values. As a measure for individual paced QRS and QTc interval changes, a regression slope coefficient (incline(i)) was calculated for each patient's course.RESULTS: Mean Z-scores for paced QRS intervals at first and last follow-up were 4.7 +/- 1.2 and 4.9 +/- 0.9 for group RV, 4.4 +/- 1.1 and 4.8 +/- 1.1 for group LV. Incline(i) of paced QRS (group RV: 0.038 [-0.27-0.12], group LV: 0.147 [-0.05-0.30]; p = 0.07) and QTc intervals (group RV: 0.026 [-0.08-0.06], group LV: 0.023 [-0.04-0.09]; p = 0.63) did not differ between both groups and indicated limited interval changes over time.CONCLUSION: Neither epicardial pacing of the right nor left ventricle caused disproportionate paced QRS or QTc interval increases over time. An age-related prolongation of the electrical activation unlikely causes ventricular dysfunction.

AB - AIMS: Permanent ventricular pacing in children is associated with ventricular dysfunction due to asynchronous activation. It is unclear whether paced QRS intervals increase disproportionately over time, which could potentially cause ventricular dysfunction.METHODS: A total of 52 children, with bipolar steroideluting epicardial leads implanted at a median age of 5.6 years (0.0-17.4), was analyzed and followed up to 12.2 years (median 3.7). Patients were subdivided in two groups: right (RV, n = 21) and left (LV, n = 31) ventricular pacing. To correct for age, standard deviation scores (Z-scores) for paced QRS and QTc intervals were calculated from published standard-ECG norm-values. As a measure for individual paced QRS and QTc interval changes, a regression slope coefficient (incline(i)) was calculated for each patient's course.RESULTS: Mean Z-scores for paced QRS intervals at first and last follow-up were 4.7 +/- 1.2 and 4.9 +/- 0.9 for group RV, 4.4 +/- 1.1 and 4.8 +/- 1.1 for group LV. Incline(i) of paced QRS (group RV: 0.038 [-0.27-0.12], group LV: 0.147 [-0.05-0.30]; p = 0.07) and QTc intervals (group RV: 0.026 [-0.08-0.06], group LV: 0.023 [-0.04-0.09]; p = 0.63) did not differ between both groups and indicated limited interval changes over time.CONCLUSION: Neither epicardial pacing of the right nor left ventricle caused disproportionate paced QRS or QTc interval increases over time. An age-related prolongation of the electrical activation unlikely causes ventricular dysfunction.

KW - Adolescent

KW - Age Factors

KW - Cardiac Pacing, Artificial/adverse effects

KW - Child

KW - Child, Preschool

KW - Drug-Eluting Stents

KW - Electrocardiography

KW - Electrodes, Implanted

KW - Female

KW - Follow-Up Studies

KW - Glucocorticoids/therapeutic use

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Male

KW - Retrospective Studies

KW - Time Factors

KW - Ventricular Dysfunction, Left/etiology

U2 - 10.1007/s00392-007-0558-0

DO - 10.1007/s00392-007-0558-0

M3 - SCORING: Journal article

C2 - 17687506

VL - 96

SP - 787

EP - 793

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 11

ER -