Evidence of gestational heroin exposure by comparative analysis of fetal and maternal body fluids, tissues, and hair in a heroin-related death.
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Evidence of gestational heroin exposure by comparative analysis of fetal and maternal body fluids, tissues, and hair in a heroin-related death. / Iwersen-Bergmann, Stefanie; Schmoldt, A; Schulz, F; Püschel, K.
in: J ANAL TOXICOL, Jahrgang 22, Nr. 4, 4, 1998, S. 296-298.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Evidence of gestational heroin exposure by comparative analysis of fetal and maternal body fluids, tissues, and hair in a heroin-related death.
AU - Iwersen-Bergmann, Stefanie
AU - Schmoldt, A
AU - Schulz, F
AU - Püschel, K
PY - 1998
Y1 - 1998
N2 - In order to determine the fetal-maternal distribution of heroin and its main metabolites (6-monoacetylmorphine and morphine) the drug concentrations were measured in autopsy material. The heroin-related death of a pregnant drug abuser (approximately the 32nd week of gestation) provided the fetal and maternal material. Fetal and maternal hair was analyzed in order to obtain long-term information on the transplacental opiate transfer. Morphine and 6-monoacetylmorphine were detected in toxic concentrations in maternal as well as in fetal tissues and body fluids. The drug concentrations in the fetal blood were significantly lower than in the maternal blood. The ratio of fetal-to-maternal (F/M) blood morphine concentration was found to be 0.39, whereas the F/M ratio of 6-monoacetylmorphine in blood was 0.15. In fetal hair analysis, morphine, heroin, and, for the first time, 6-monoacetylmorphine were measured. The resulting F/M ratios were 0.49, 0.36, and 0.6, respectively.
AB - In order to determine the fetal-maternal distribution of heroin and its main metabolites (6-monoacetylmorphine and morphine) the drug concentrations were measured in autopsy material. The heroin-related death of a pregnant drug abuser (approximately the 32nd week of gestation) provided the fetal and maternal material. Fetal and maternal hair was analyzed in order to obtain long-term information on the transplacental opiate transfer. Morphine and 6-monoacetylmorphine were detected in toxic concentrations in maternal as well as in fetal tissues and body fluids. The drug concentrations in the fetal blood were significantly lower than in the maternal blood. The ratio of fetal-to-maternal (F/M) blood morphine concentration was found to be 0.39, whereas the F/M ratio of 6-monoacetylmorphine in blood was 0.15. In fetal hair analysis, morphine, heroin, and, for the first time, 6-monoacetylmorphine were measured. The resulting F/M ratios were 0.49, 0.36, and 0.6, respectively.
KW - Adult
KW - Humans
KW - Female
KW - Pregnancy
KW - Autopsy
KW - Maternal-Fetal Exchange
KW - Fetus/chemistry
KW - Hair/chemistry
KW - Heroin/analysis/toxicity
KW - Morphine/analysis
KW - Morphine Derivatives/analysis
KW - Narcotics/analysis/toxicity
KW - Substance-Related Disorders/diagnosis
KW - Adult
KW - Humans
KW - Female
KW - Pregnancy
KW - Autopsy
KW - Maternal-Fetal Exchange
KW - Fetus/chemistry
KW - Hair/chemistry
KW - Heroin/analysis/toxicity
KW - Morphine/analysis
KW - Morphine Derivatives/analysis
KW - Narcotics/analysis/toxicity
KW - Substance-Related Disorders/diagnosis
U2 - 10.1093/jat/22.4.296
DO - 10.1093/jat/22.4.296
M3 - SCORING: Journal article
VL - 22
SP - 296
EP - 298
JO - J ANAL TOXICOL
JF - J ANAL TOXICOL
SN - 0146-4760
IS - 4
M1 - 4
ER -
