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Evidence of a genetic link between endometriosis and ovarian cancer

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Evidence of a genetic link between endometriosis and ovarian cancer. / Lee, Alice W; Templeman, Claire; Stram, Douglas A; Beesley, Jonathan; Tyrer, Jonathan; Berchuck, Andrew; Pharoah, Paul P; Chenevix-Trench, Georgia; Pearce, Celeste Leigh; Ovarian Cancer Association Consortium.

in: FERTIL STERIL, Jahrgang 105, Nr. 1, 01.2016, S. 35-43.e10.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lee, AW, Templeman, C, Stram, DA, Beesley, J, Tyrer, J, Berchuck, A, Pharoah, PP, Chenevix-Trench, G, Pearce, CL & Ovarian Cancer Association Consortium 2016, 'Evidence of a genetic link between endometriosis and ovarian cancer', FERTIL STERIL, Jg. 105, Nr. 1, S. 35-43.e10. https://doi.org/10.1016/j.fertnstert.2015.09.023

APA

Lee, A. W., Templeman, C., Stram, D. A., Beesley, J., Tyrer, J., Berchuck, A., Pharoah, P. P., Chenevix-Trench, G., Pearce, C. L., & Ovarian Cancer Association Consortium (2016). Evidence of a genetic link between endometriosis and ovarian cancer. FERTIL STERIL, 105(1), 35-43.e10. https://doi.org/10.1016/j.fertnstert.2015.09.023

Vancouver

Lee AW, Templeman C, Stram DA, Beesley J, Tyrer J, Berchuck A et al. Evidence of a genetic link between endometriosis and ovarian cancer. FERTIL STERIL. 2016 Jan;105(1):35-43.e10. https://doi.org/10.1016/j.fertnstert.2015.09.023

Bibtex

@article{df587336f90d452682c5edd75c8aca69,
title = "Evidence of a genetic link between endometriosis and ovarian cancer",
abstract = "OBJECTIVE: To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.DESIGN: Pooled genetic analysis.SETTING: University hospital.PATIENT(S): Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Endometriosis-associated genetic variation and ovarian cancer.RESULT(S): There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected.CONCLUSION(S): By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions.",
author = "Lee, {Alice W} and Claire Templeman and Stram, {Douglas A} and Jonathan Beesley and Jonathan Tyrer and Andrew Berchuck and Pharoah, {Paul P} and Georgia Chenevix-Trench and Pearce, {Celeste Leigh} and {Ovarian Cancer Association Consortium}",
note = "Copyright {\textcopyright} 2016. Published by Elsevier Inc.",
year = "2016",
month = jan,
doi = "10.1016/j.fertnstert.2015.09.023",
language = "English",
volume = "105",
pages = "35--43.e10",
journal = "FERTIL STERIL",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Evidence of a genetic link between endometriosis and ovarian cancer

AU - Lee, Alice W

AU - Templeman, Claire

AU - Stram, Douglas A

AU - Beesley, Jonathan

AU - Tyrer, Jonathan

AU - Berchuck, Andrew

AU - Pharoah, Paul P

AU - Chenevix-Trench, Georgia

AU - Pearce, Celeste Leigh

AU - Ovarian Cancer Association Consortium

N1 - Copyright © 2016. Published by Elsevier Inc.

PY - 2016/1

Y1 - 2016/1

N2 - OBJECTIVE: To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.DESIGN: Pooled genetic analysis.SETTING: University hospital.PATIENT(S): Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Endometriosis-associated genetic variation and ovarian cancer.RESULT(S): There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected.CONCLUSION(S): By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions.

AB - OBJECTIVE: To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.DESIGN: Pooled genetic analysis.SETTING: University hospital.PATIENT(S): Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies.INTERVENTION(S): None.MAIN OUTCOME MEASURE(S): Endometriosis-associated genetic variation and ovarian cancer.RESULT(S): There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected.CONCLUSION(S): By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions.

U2 - 10.1016/j.fertnstert.2015.09.023

DO - 10.1016/j.fertnstert.2015.09.023

M3 - SCORING: Journal article

C2 - 26477498

VL - 105

SP - 35-43.e10

JO - FERTIL STERIL

JF - FERTIL STERIL

SN - 0015-0282

IS - 1

ER -