Evidence for T cell receptor-HLA class II molecule interaction in the response to superantigenic bacterial toxins

TY - JOUR

T1 - Evidence for T cell receptor-HLA class II molecule interaction in the response to superantigenic bacterial toxins

AU - Fleischer, B

AU - Mittrücker, H W

PY - 1991/5/1

Y1 - 1991/5/1

N2 - The staphylococcal enterotoxins and related microbial T cell mitogens stimulate T cells by cross-linking variable parts of the T cell receptor (TcR) with MHC class II molecules on accessory or target cells. In this report we describe that a given combination of T cell, accessory cell (AC) and toxin can be non-stimulatory. However, the same T cell can respond to the same toxin on another AC and the same AC can present the same toxin to another T cell. This indicates that in the complex formed between TcR, toxin and class II molecule an interaction between TcR and class II molecule takes place.

AB - The staphylococcal enterotoxins and related microbial T cell mitogens stimulate T cells by cross-linking variable parts of the T cell receptor (TcR) with MHC class II molecules on accessory or target cells. In this report we describe that a given combination of T cell, accessory cell (AC) and toxin can be non-stimulatory. However, the same T cell can respond to the same toxin on another AC and the same AC can present the same toxin to another T cell. This indicates that in the complex formed between TcR, toxin and class II molecule an interaction between TcR and class II molecule takes place.

KW - Antigen-Presenting Cells

KW - Bacterial Toxins

KW - Histocompatibility Antigens Class II

KW - Humans

KW - Lymphocyte Activation

KW - Receptors, Antigen, T-Cell

KW - T-Lymphocytes

U2 - 10.1002/eji.1830210537

DO - 10.1002/eji.1830210537

M3 - SCORING: Journal article

C2 - 2037017

VL - 21

SP - 1331

EP - 1333

JO - EUR J IMMUNOL

JF - EUR J IMMUNOL

SN - 0014-2980

IS - 5

ER -