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Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS

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Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS. / Morgen, Katrin; Sammer, Gebhard; Courtney, Susan M; Wolters, Tobias; Melchior, Hanne; Blecker, Carlo R; Oschmann, Patrick; Kaps, Manfred; Vaitl, Dieter.

in: NEUROIMAGE, Jahrgang 30, Nr. 3, 15.04.2006, S. 891-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Morgen, K, Sammer, G, Courtney, SM, Wolters, T, Melchior, H, Blecker, CR, Oschmann, P, Kaps, M & Vaitl, D 2006, 'Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS', NEUROIMAGE, Jg. 30, Nr. 3, S. 891-8. https://doi.org/10.1016/j.neuroimage.2005.10.032

APA

Morgen, K., Sammer, G., Courtney, S. M., Wolters, T., Melchior, H., Blecker, C. R., Oschmann, P., Kaps, M., & Vaitl, D. (2006). Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS. NEUROIMAGE, 30(3), 891-8. https://doi.org/10.1016/j.neuroimage.2005.10.032

Vancouver

Morgen K, Sammer G, Courtney SM, Wolters T, Melchior H, Blecker CR et al. Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS. NEUROIMAGE. 2006 Apr 15;30(3):891-8. https://doi.org/10.1016/j.neuroimage.2005.10.032

Bibtex

@article{e46a1c9fd36640efadab7526870d9de2,
title = "Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS",
abstract = "Cognitive deficits affecting memory, attention and speed of information processing are common in multiple sclerosis (MS). The mechanisms of cognitive impairment remain unclear. Here, we examined the association between neuropsychological test performance and brain atrophy in a group of mildly disabled patients with relapsing-remitting MS. We applied voxel-based morphometry (SPM2) to investigate the distribution of brain atrophy in relation to cognitive performance. Patients had lower scores than control subjects on tests of memory and executive function, including the PASAT, Digit Span Backward and a test of short-term verbal memory (Memo). Among patients, but not healthy controls, performance on the PASAT, a comprehensive measure of cognitive function and reference task for the cognitive evaluation of MS-patients, correlated with global grey matter volume as well as with grey matter volume in regions associated with working memory and executive function, including bilateral prefrontal cortex, precentral gyrus and superior parietal cortex as well as right cerebellum. Compared to healthy subjects, patients showed a volume reduction in left temporal and prefrontal cortex, recently identified as areas predominantly affected by diffuse brain atrophy in MS. A comparison of low performers in the patient group with their matched control subjects showed more extensive and bilateral temporal and frontal volume reductions as well as bilateral parietal volume loss, compatible with the progression of atrophy found in more advanced MS-patients. These findings indicate that MS-related deficits in cognition are closely associated with cortical atrophy.",
keywords = "Adult, Atrophy, Cerebral Cortex, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Organ Size",
author = "Katrin Morgen and Gebhard Sammer and Courtney, {Susan M} and Tobias Wolters and Hanne Melchior and Blecker, {Carlo R} and Patrick Oschmann and Manfred Kaps and Dieter Vaitl",
year = "2006",
month = apr,
day = "15",
doi = "10.1016/j.neuroimage.2005.10.032",
language = "English",
volume = "30",
pages = "891--8",
journal = "NEUROIMAGE",
issn = "1053-8119",
publisher = "Academic Press",
number = "3",

}

RIS

TY - JOUR

T1 - Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing-remitting MS

AU - Morgen, Katrin

AU - Sammer, Gebhard

AU - Courtney, Susan M

AU - Wolters, Tobias

AU - Melchior, Hanne

AU - Blecker, Carlo R

AU - Oschmann, Patrick

AU - Kaps, Manfred

AU - Vaitl, Dieter

PY - 2006/4/15

Y1 - 2006/4/15

N2 - Cognitive deficits affecting memory, attention and speed of information processing are common in multiple sclerosis (MS). The mechanisms of cognitive impairment remain unclear. Here, we examined the association between neuropsychological test performance and brain atrophy in a group of mildly disabled patients with relapsing-remitting MS. We applied voxel-based morphometry (SPM2) to investigate the distribution of brain atrophy in relation to cognitive performance. Patients had lower scores than control subjects on tests of memory and executive function, including the PASAT, Digit Span Backward and a test of short-term verbal memory (Memo). Among patients, but not healthy controls, performance on the PASAT, a comprehensive measure of cognitive function and reference task for the cognitive evaluation of MS-patients, correlated with global grey matter volume as well as with grey matter volume in regions associated with working memory and executive function, including bilateral prefrontal cortex, precentral gyrus and superior parietal cortex as well as right cerebellum. Compared to healthy subjects, patients showed a volume reduction in left temporal and prefrontal cortex, recently identified as areas predominantly affected by diffuse brain atrophy in MS. A comparison of low performers in the patient group with their matched control subjects showed more extensive and bilateral temporal and frontal volume reductions as well as bilateral parietal volume loss, compatible with the progression of atrophy found in more advanced MS-patients. These findings indicate that MS-related deficits in cognition are closely associated with cortical atrophy.

AB - Cognitive deficits affecting memory, attention and speed of information processing are common in multiple sclerosis (MS). The mechanisms of cognitive impairment remain unclear. Here, we examined the association between neuropsychological test performance and brain atrophy in a group of mildly disabled patients with relapsing-remitting MS. We applied voxel-based morphometry (SPM2) to investigate the distribution of brain atrophy in relation to cognitive performance. Patients had lower scores than control subjects on tests of memory and executive function, including the PASAT, Digit Span Backward and a test of short-term verbal memory (Memo). Among patients, but not healthy controls, performance on the PASAT, a comprehensive measure of cognitive function and reference task for the cognitive evaluation of MS-patients, correlated with global grey matter volume as well as with grey matter volume in regions associated with working memory and executive function, including bilateral prefrontal cortex, precentral gyrus and superior parietal cortex as well as right cerebellum. Compared to healthy subjects, patients showed a volume reduction in left temporal and prefrontal cortex, recently identified as areas predominantly affected by diffuse brain atrophy in MS. A comparison of low performers in the patient group with their matched control subjects showed more extensive and bilateral temporal and frontal volume reductions as well as bilateral parietal volume loss, compatible with the progression of atrophy found in more advanced MS-patients. These findings indicate that MS-related deficits in cognition are closely associated with cortical atrophy.

KW - Adult

KW - Atrophy

KW - Cerebral Cortex

KW - Cognition Disorders

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis, Relapsing-Remitting

KW - Organ Size

U2 - 10.1016/j.neuroimage.2005.10.032

DO - 10.1016/j.neuroimage.2005.10.032

M3 - SCORING: Journal article

C2 - 16360321

VL - 30

SP - 891

EP - 898

JO - NEUROIMAGE

JF - NEUROIMAGE

SN - 1053-8119

IS - 3

ER -