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Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract

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Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract. / Volgger, Veronika; Stepp, Herbert; Ihrler, Stephan; Kraft, Marcel; Leunig, Andreas; Patel, Parag M; Susarla, Malavika; Jackson, Kathleen; Betz, Christian S.

in: HEAD NECK-J SCI SPEC, Jahrgang 35, Nr. 11, 11.2013, S. 1558-66.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Volgger, V, Stepp, H, Ihrler, S, Kraft, M, Leunig, A, Patel, PM, Susarla, M, Jackson, K & Betz, CS 2013, 'Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract', HEAD NECK-J SCI SPEC, Jg. 35, Nr. 11, S. 1558-66. https://doi.org/10.1002/hed.23189

APA

Volgger, V., Stepp, H., Ihrler, S., Kraft, M., Leunig, A., Patel, P. M., Susarla, M., Jackson, K., & Betz, C. S. (2013). Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract. HEAD NECK-J SCI SPEC, 35(11), 1558-66. https://doi.org/10.1002/hed.23189

Vancouver

Volgger V, Stepp H, Ihrler S, Kraft M, Leunig A, Patel PM et al. Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract. HEAD NECK-J SCI SPEC. 2013 Nov;35(11):1558-66. https://doi.org/10.1002/hed.23189

Bibtex

@article{2abccaa2c87e4f0e94491268b523a15a,
title = "Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract",
abstract = "BACKGROUND: This study evaluated the capability of optical coherence tomography (OCT) to differentiate premalignant and early malignant lesions of the upper aerodigestive tract (UADT).METHODS: An OCT screening was performed in 52 healthy volunteers. Epithelial thicknesses on 38 OCT images and histopathological slides were correlated. One hundred primary lesions were rated via OCT concerning invasiveness by an {"}unblinded{"} investigator, then biopsied, and the results correlated. All OCT images were evaluated by 3 {"}blinded{"} investigators. Forty-eight images underwent retrospective image analysis.RESULTS: Screening showed large differences concerning epithelial thicknesses, but good correlation (κ = 0.63) between OCT and histopathological slides. In the unblinded evaluation, noninvasive and invasive lesions could be distinguished with a sensitivity of 88.9% and specificity of 89.0% whereas the blinded evaluations led to sensitivities of 100%, 66.7%, and 77.8% and specificities of 75.8%, 71.4%, and 70.3%. The difference of mean intraepithelial intensity reductions in dysplasias (38.7%) and hyperplasias (18.9%) was statistically significant.CONCLUSION: OCT complements visual inspection for differentiating UADT-lesions.",
keywords = "Adult, Aged, Carcinoma, Squamous Cell, Case-Control Studies, Diagnosis, Differential, Early Detection of Cancer, Female, Healthy Volunteers, Humans, Laryngeal Neoplasms, Male, Middle Aged, Mouth Neoplasms, Neoplasm Invasiveness, Neoplasm Staging, Observer Variation, Oropharyngeal Neoplasms, Precancerous Conditions, Prospective Studies, Reference Values, Sensitivity and Specificity, Statistics, Nonparametric, Tomography, Optical Coherence, Young Adult, Comparative Study, Evaluation Studies, Journal Article",
author = "Veronika Volgger and Herbert Stepp and Stephan Ihrler and Marcel Kraft and Andreas Leunig and Patel, {Parag M} and Malavika Susarla and Kathleen Jackson and Betz, {Christian S}",
note = "Copyright {\textcopyright} 2012 Wiley Periodicals, Inc.",
year = "2013",
month = nov,
doi = "10.1002/hed.23189",
language = "English",
volume = "35",
pages = "1558--66",
journal = "HEAD NECK-J SCI SPEC",
issn = "1043-3074",
publisher = "John Wiley and Sons Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Evaluation of optical coherence tomography to discriminate lesions of the upper aerodigestive tract

AU - Volgger, Veronika

AU - Stepp, Herbert

AU - Ihrler, Stephan

AU - Kraft, Marcel

AU - Leunig, Andreas

AU - Patel, Parag M

AU - Susarla, Malavika

AU - Jackson, Kathleen

AU - Betz, Christian S

N1 - Copyright © 2012 Wiley Periodicals, Inc.

PY - 2013/11

Y1 - 2013/11

N2 - BACKGROUND: This study evaluated the capability of optical coherence tomography (OCT) to differentiate premalignant and early malignant lesions of the upper aerodigestive tract (UADT).METHODS: An OCT screening was performed in 52 healthy volunteers. Epithelial thicknesses on 38 OCT images and histopathological slides were correlated. One hundred primary lesions were rated via OCT concerning invasiveness by an "unblinded" investigator, then biopsied, and the results correlated. All OCT images were evaluated by 3 "blinded" investigators. Forty-eight images underwent retrospective image analysis.RESULTS: Screening showed large differences concerning epithelial thicknesses, but good correlation (κ = 0.63) between OCT and histopathological slides. In the unblinded evaluation, noninvasive and invasive lesions could be distinguished with a sensitivity of 88.9% and specificity of 89.0% whereas the blinded evaluations led to sensitivities of 100%, 66.7%, and 77.8% and specificities of 75.8%, 71.4%, and 70.3%. The difference of mean intraepithelial intensity reductions in dysplasias (38.7%) and hyperplasias (18.9%) was statistically significant.CONCLUSION: OCT complements visual inspection for differentiating UADT-lesions.

AB - BACKGROUND: This study evaluated the capability of optical coherence tomography (OCT) to differentiate premalignant and early malignant lesions of the upper aerodigestive tract (UADT).METHODS: An OCT screening was performed in 52 healthy volunteers. Epithelial thicknesses on 38 OCT images and histopathological slides were correlated. One hundred primary lesions were rated via OCT concerning invasiveness by an "unblinded" investigator, then biopsied, and the results correlated. All OCT images were evaluated by 3 "blinded" investigators. Forty-eight images underwent retrospective image analysis.RESULTS: Screening showed large differences concerning epithelial thicknesses, but good correlation (κ = 0.63) between OCT and histopathological slides. In the unblinded evaluation, noninvasive and invasive lesions could be distinguished with a sensitivity of 88.9% and specificity of 89.0% whereas the blinded evaluations led to sensitivities of 100%, 66.7%, and 77.8% and specificities of 75.8%, 71.4%, and 70.3%. The difference of mean intraepithelial intensity reductions in dysplasias (38.7%) and hyperplasias (18.9%) was statistically significant.CONCLUSION: OCT complements visual inspection for differentiating UADT-lesions.

KW - Adult

KW - Aged

KW - Carcinoma, Squamous Cell

KW - Case-Control Studies

KW - Diagnosis, Differential

KW - Early Detection of Cancer

KW - Female

KW - Healthy Volunteers

KW - Humans

KW - Laryngeal Neoplasms

KW - Male

KW - Middle Aged

KW - Mouth Neoplasms

KW - Neoplasm Invasiveness

KW - Neoplasm Staging

KW - Observer Variation

KW - Oropharyngeal Neoplasms

KW - Precancerous Conditions

KW - Prospective Studies

KW - Reference Values

KW - Sensitivity and Specificity

KW - Statistics, Nonparametric

KW - Tomography, Optical Coherence

KW - Young Adult

KW - Comparative Study

KW - Evaluation Studies

KW - Journal Article

U2 - 10.1002/hed.23189

DO - 10.1002/hed.23189

M3 - SCORING: Journal article

C2 - 23108943

VL - 35

SP - 1558

EP - 1566

JO - HEAD NECK-J SCI SPEC

JF - HEAD NECK-J SCI SPEC

SN - 1043-3074

IS - 11

ER -