Evaluation of Eosinophilic Cationic Protein as a Marker of Alveolar and Cystic Echinococcosis
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Evaluation of Eosinophilic Cationic Protein as a Marker of Alveolar and Cystic Echinococcosis. / Hotz, Julian Frederic; Kaczirek, Klaus; Stremitzer, Stefan; Waneck, Fredrik; Auer, Herbert; Perkmann, Thomas; Kussmann, Manuel; Bauer, Philipp Karl; Chen, Rui-Yang; Kriz, Richard; Burgmann, Heinz; Ramharter, Michael; Lagler, Heimo.
in: PATHOGENS, Jahrgang 11, Nr. 2, 261, 18.02.2022.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Evaluation of Eosinophilic Cationic Protein as a Marker of Alveolar and Cystic Echinococcosis
AU - Hotz, Julian Frederic
AU - Kaczirek, Klaus
AU - Stremitzer, Stefan
AU - Waneck, Fredrik
AU - Auer, Herbert
AU - Perkmann, Thomas
AU - Kussmann, Manuel
AU - Bauer, Philipp Karl
AU - Chen, Rui-Yang
AU - Kriz, Richard
AU - Burgmann, Heinz
AU - Ramharter, Michael
AU - Lagler, Heimo
PY - 2022/2/18
Y1 - 2022/2/18
N2 - Echinococcosis is a neglected zoonotic disease and a worldwide public health problem caused by infection with the larval stages of taeniid cestodes of the genus Echinococcus. In vitro studies have demonstrated a protoscolecidal effect of eosinophilic cationic protein (ECP), a granule protein of eosinophilic granulocytes, against E. granulosus. Therefore, the main objective of this study was to evaluate ECP as a biomarker in the treatment of alveolar echinococcosis (AE) and cystic echinococcosis (CE). Data were collected retrospectively from the Vienna Echinococcosis Cohort over 7 years until December 2020. Altogether, 32 patients (16 AE and 16 CE) were included. In the selected patients, serum ECP values were compared before and after the beginning of an operative and/or benzimidazole (BMZ) therapy. Mean ECP serum levels before intervention were significantly (p < 0.05) elevated at 34.0 ± 22.9 μg/L in AE patients and at 38.6 ± 19.9 μg/L in CE patients compared to the control group. After the intervention, mean ECP levels decreased significantly (p < 0.05) to 20.4 ± 14.6 μg/L in AE patients and to 22.4 ± 8.3 μg/L in CE patients. Furthermore, ECP showed a significant (p < 0.05) correlation of k = 0.56 with PET-CTI. Based on the significant decrease after operative and/or BMZ treatment and the correlation with clinical markers such as PET-CTI, it is recommended to investigate ECP more intensively as a marker of AE and CE in prospective studies with larger cohorts.
AB - Echinococcosis is a neglected zoonotic disease and a worldwide public health problem caused by infection with the larval stages of taeniid cestodes of the genus Echinococcus. In vitro studies have demonstrated a protoscolecidal effect of eosinophilic cationic protein (ECP), a granule protein of eosinophilic granulocytes, against E. granulosus. Therefore, the main objective of this study was to evaluate ECP as a biomarker in the treatment of alveolar echinococcosis (AE) and cystic echinococcosis (CE). Data were collected retrospectively from the Vienna Echinococcosis Cohort over 7 years until December 2020. Altogether, 32 patients (16 AE and 16 CE) were included. In the selected patients, serum ECP values were compared before and after the beginning of an operative and/or benzimidazole (BMZ) therapy. Mean ECP serum levels before intervention were significantly (p < 0.05) elevated at 34.0 ± 22.9 μg/L in AE patients and at 38.6 ± 19.9 μg/L in CE patients compared to the control group. After the intervention, mean ECP levels decreased significantly (p < 0.05) to 20.4 ± 14.6 μg/L in AE patients and to 22.4 ± 8.3 μg/L in CE patients. Furthermore, ECP showed a significant (p < 0.05) correlation of k = 0.56 with PET-CTI. Based on the significant decrease after operative and/or BMZ treatment and the correlation with clinical markers such as PET-CTI, it is recommended to investigate ECP more intensively as a marker of AE and CE in prospective studies with larger cohorts.
U2 - 10.3390/pathogens11020261
DO - 10.3390/pathogens11020261
M3 - SCORING: Journal article
C2 - 35215203
VL - 11
JO - PATHOGENS
JF - PATHOGENS
SN - 2076-0817
IS - 2
M1 - 261
ER -