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Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma.

Standard

Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma. / Gabriel, Ute; Bolenz, Christian; Becker, Andreas; Schaaf, Axel; Steidler, Annette; Trojan, Lutz; Weiss, Christel; Michel, Maurice Stephan.

in: ONCOL REP, Jahrgang 20, Nr. 6, 6, 2008, S. 1419-1423.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gabriel, U, Bolenz, C, Becker, A, Schaaf, A, Steidler, A, Trojan, L, Weiss, C & Michel, MS 2008, 'Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma.', ONCOL REP, Jg. 20, Nr. 6, 6, S. 1419-1423. <http://www.ncbi.nlm.nih.gov/pubmed/19020723?dopt=Citation>

APA

Gabriel, U., Bolenz, C., Becker, A., Schaaf, A., Steidler, A., Trojan, L., Weiss, C., & Michel, M. S. (2008). Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma. ONCOL REP, 20(6), 1419-1423. [6]. http://www.ncbi.nlm.nih.gov/pubmed/19020723?dopt=Citation

Vancouver

Gabriel U, Bolenz C, Becker A, Schaaf A, Steidler A, Trojan L et al. Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma. ONCOL REP. 2008;20(6):1419-1423. 6.

Bibtex

@article{b6866564eb0246488a9e4aab280f4009,
title = "Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma.",
abstract = "We report on cytotoxic effects of bcl-2 and bcl-xL antisense-oligodeoxynucleotides (AS-ODNs) in benign urothelial and transitional cell carcinoma (TCC) cell lines. The benign urothelial cell line (UROtsa) and four TCC cell lines (UM-UC-3, RT 112 , HT 1197 and T 24/83) were incubated with bcl-2 and bcl-xL AS-ODNs and cell mortality rates were assessed. Bcl-2 and bcl-xL AS-ODN treatment resulted in low toxicity in UROtsa cells (6% and 10% cell mortality, respectively). After bcl-2 AS-ODN treatment, cell mortality rates in TCC cell lines were significantly higher than in UROtsa cells (mean values: 33% vs. 6%, respectively). Bcl-2 AS-ODN treatment also caused significantly higher cell death rates in the majority of TCC cell lines when compared to bcl-xL-AS-ODN therapy (mean values: 33% vs. 11%, respectively). In conclusion, bcl-2 AS-ODNs show significantly higher cell mortality in TCC cells, whereas toxic effects on normal urothelium seem to be minor. Our results suggest favourable characteristics for the clinical application of AS-ODN in intravesical chemotherapy of TCC.",
author = "Ute Gabriel and Christian Bolenz and Andreas Becker and Axel Schaaf and Annette Steidler and Lutz Trojan and Christel Weiss and Michel, {Maurice Stephan}",
year = "2008",
language = "Deutsch",
volume = "20",
pages = "1419--1423",
journal = "ONCOL REP",
issn = "1021-335X",
publisher = "Spandidos Publications",
number = "6",

}

RIS

TY - JOUR

T1 - Evaluation of cytotoxic effects induced by bcl-2 and bcl-xL antisense-oligodeoxynucleotides in normal urothelium and transitional cell carcinoma.

AU - Gabriel, Ute

AU - Bolenz, Christian

AU - Becker, Andreas

AU - Schaaf, Axel

AU - Steidler, Annette

AU - Trojan, Lutz

AU - Weiss, Christel

AU - Michel, Maurice Stephan

PY - 2008

Y1 - 2008

N2 - We report on cytotoxic effects of bcl-2 and bcl-xL antisense-oligodeoxynucleotides (AS-ODNs) in benign urothelial and transitional cell carcinoma (TCC) cell lines. The benign urothelial cell line (UROtsa) and four TCC cell lines (UM-UC-3, RT 112 , HT 1197 and T 24/83) were incubated with bcl-2 and bcl-xL AS-ODNs and cell mortality rates were assessed. Bcl-2 and bcl-xL AS-ODN treatment resulted in low toxicity in UROtsa cells (6% and 10% cell mortality, respectively). After bcl-2 AS-ODN treatment, cell mortality rates in TCC cell lines were significantly higher than in UROtsa cells (mean values: 33% vs. 6%, respectively). Bcl-2 AS-ODN treatment also caused significantly higher cell death rates in the majority of TCC cell lines when compared to bcl-xL-AS-ODN therapy (mean values: 33% vs. 11%, respectively). In conclusion, bcl-2 AS-ODNs show significantly higher cell mortality in TCC cells, whereas toxic effects on normal urothelium seem to be minor. Our results suggest favourable characteristics for the clinical application of AS-ODN in intravesical chemotherapy of TCC.

AB - We report on cytotoxic effects of bcl-2 and bcl-xL antisense-oligodeoxynucleotides (AS-ODNs) in benign urothelial and transitional cell carcinoma (TCC) cell lines. The benign urothelial cell line (UROtsa) and four TCC cell lines (UM-UC-3, RT 112 , HT 1197 and T 24/83) were incubated with bcl-2 and bcl-xL AS-ODNs and cell mortality rates were assessed. Bcl-2 and bcl-xL AS-ODN treatment resulted in low toxicity in UROtsa cells (6% and 10% cell mortality, respectively). After bcl-2 AS-ODN treatment, cell mortality rates in TCC cell lines were significantly higher than in UROtsa cells (mean values: 33% vs. 6%, respectively). Bcl-2 AS-ODN treatment also caused significantly higher cell death rates in the majority of TCC cell lines when compared to bcl-xL-AS-ODN therapy (mean values: 33% vs. 11%, respectively). In conclusion, bcl-2 AS-ODNs show significantly higher cell mortality in TCC cells, whereas toxic effects on normal urothelium seem to be minor. Our results suggest favourable characteristics for the clinical application of AS-ODN in intravesical chemotherapy of TCC.

M3 - SCORING: Zeitschriftenaufsatz

VL - 20

SP - 1419

EP - 1423

JO - ONCOL REP

JF - ONCOL REP

SN - 1021-335X

IS - 6

M1 - 6

ER -