Evaluation of confocal laser endomicroscopy as an aid to differentiate primary flat lesions of the larynx
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Evaluation of confocal laser endomicroscopy as an aid to differentiate primary flat lesions of the larynx : A prospective clinical study. / Volgger, Veronika; Girschick, Susanne; Ihrler, Stephan; Englhard, Anna Sophie; Stepp, Herbert; Betz, Christian Stephan.
in: HEAD NECK-J SCI SPEC, Jahrgang 38 Suppl 1, 04.2016, S. E1695-704.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Evaluation of confocal laser endomicroscopy as an aid to differentiate primary flat lesions of the larynx
T2 - A prospective clinical study
AU - Volgger, Veronika
AU - Girschick, Susanne
AU - Ihrler, Stephan
AU - Englhard, Anna Sophie
AU - Stepp, Herbert
AU - Betz, Christian Stephan
N1 - © 2015 Wiley Periodicals, Inc.
PY - 2016/4
Y1 - 2016/4
N2 - BACKGROUND: In this trial, the ability of confocal laser endomicroscopy (CLE), a new imaging modality with a cellular resolution, to further differentiate primary flat lesions of the larynx was evaluated.METHODS: First, an optical coherence tomography was used to filter out normal tissue and carcinoma. All other lesions (30 lesions in 19 patients) were investigated with CLE. The suspected diagnosis was compared to histopathology.RESULTS: Optical coherence tomography identified all noninvasive lesions. CLE provided further information with cellular resolution. In 2 of 30 cases, low image quality prevented classification. In laryngeal lesions (27 of 30), moderate to high-grade dysplasia was correctly suspected in 10 of 10 cases (100%). Hyperplasia was overrated as dysplasia in 7 of 15 cases (46.7%). Sensitivity was 100% and specificity was 40%.CONCLUSION: When used in conjunction with optical coherence tomography, CLE seems helpful for discrimination of noninvasive lesions, although it tends to overrate the severity of the changes. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1695-E1704, 2016.
AB - BACKGROUND: In this trial, the ability of confocal laser endomicroscopy (CLE), a new imaging modality with a cellular resolution, to further differentiate primary flat lesions of the larynx was evaluated.METHODS: First, an optical coherence tomography was used to filter out normal tissue and carcinoma. All other lesions (30 lesions in 19 patients) were investigated with CLE. The suspected diagnosis was compared to histopathology.RESULTS: Optical coherence tomography identified all noninvasive lesions. CLE provided further information with cellular resolution. In 2 of 30 cases, low image quality prevented classification. In laryngeal lesions (27 of 30), moderate to high-grade dysplasia was correctly suspected in 10 of 10 cases (100%). Hyperplasia was overrated as dysplasia in 7 of 15 cases (46.7%). Sensitivity was 100% and specificity was 40%.CONCLUSION: When used in conjunction with optical coherence tomography, CLE seems helpful for discrimination of noninvasive lesions, although it tends to overrate the severity of the changes. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1695-E1704, 2016.
KW - Endoscopy
KW - Erythroplasia
KW - Female
KW - Humans
KW - Laryngeal Diseases
KW - Larynx
KW - Leukoplakia
KW - Male
KW - Microscopy, Confocal
KW - Middle Aged
KW - Prospective Studies
KW - Sensitivity and Specificity
KW - Tomography, Optical Coherence
KW - Clinical Trial
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1002/hed.24303
DO - 10.1002/hed.24303
M3 - SCORING: Journal article
C2 - 26614354
VL - 38 Suppl 1
SP - E1695-704
JO - HEAD NECK-J SCI SPEC
JF - HEAD NECK-J SCI SPEC
SN - 1043-3074
ER -
