Evaluation of bone substitute materials: comparison of flat-panel based volume CT to conventional multidetector CT
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Evaluation of bone substitute materials: comparison of flat-panel based volume CT to conventional multidetector CT. / Sauerbier, Sebastian; Duttenhoefer, Fabian; Sachlos, Elefterios; Haberstroh, Jörg; Scheifele, Christian; Wrbas, Karl-Thomas; Voss, Pit Jacob; Veigel, Egle; Smedek, Jörg; Ganter, Philip; Tuna, Taskin; Gutwald, Ralf; Palmowski, Moritz.
in: J CRANIO MAXILL SURG, Jahrgang 41, Nr. 7, 01.10.2013, S. e128-136.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Evaluation of bone substitute materials: comparison of flat-panel based volume CT to conventional multidetector CT
AU - Sauerbier, Sebastian
AU - Duttenhoefer, Fabian
AU - Sachlos, Elefterios
AU - Haberstroh, Jörg
AU - Scheifele, Christian
AU - Wrbas, Karl-Thomas
AU - Voss, Pit Jacob
AU - Veigel, Egle
AU - Smedek, Jörg
AU - Ganter, Philip
AU - Tuna, Taskin
AU - Gutwald, Ralf
AU - Palmowski, Moritz
N1 - Copyright © 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
PY - 2013/10/1
Y1 - 2013/10/1
N2 - Over the last decade tissue engineering has emerged as a key factor in bone regeneration within the field of cranio-maxillofacial surgery. Despite this in vivo analysis of tissue-engineered-constructs to monitor bone rehabilitation are difficult to conduct. Novel high-resolving flat-panel based volume CTs (fp-VCT) are increasingly used for imaging bone structures. This study compares the potential value of novel fp-VCT with conventional multidetector CT (MDCT) based on a sheep sinus floor elevation model. Calcium-hydroxyapatite reinforced collagen scaffolds were populated with autologous osteoblasts and implanted into sheep maxillary sinus. After 8, 16 and 24 weeks MDCT and fp-VCT scans were performed to investigate the volume of the augmented area; densities of cancellous and compact bone were assessed as comparative values. fp-VCT imaging resulted in higher spatial resolution, which was advantageous when separating closely related anatomical structures (i.e. trabecular and compact bone, biomaterials). Fp-VCT facilitated imaging of alterations occurring in test specimens over time. fp-VCTs therefore displayed high volume coverage, dynamic imaging potential and superior performance when investigating superfine bone structures and bone remodelling of biomaterials. Thus, fp-VCTs may be a suitable instrument for intraoperative imaging and future in vivo tissue-engineering studies.
AB - Over the last decade tissue engineering has emerged as a key factor in bone regeneration within the field of cranio-maxillofacial surgery. Despite this in vivo analysis of tissue-engineered-constructs to monitor bone rehabilitation are difficult to conduct. Novel high-resolving flat-panel based volume CTs (fp-VCT) are increasingly used for imaging bone structures. This study compares the potential value of novel fp-VCT with conventional multidetector CT (MDCT) based on a sheep sinus floor elevation model. Calcium-hydroxyapatite reinforced collagen scaffolds were populated with autologous osteoblasts and implanted into sheep maxillary sinus. After 8, 16 and 24 weeks MDCT and fp-VCT scans were performed to investigate the volume of the augmented area; densities of cancellous and compact bone were assessed as comparative values. fp-VCT imaging resulted in higher spatial resolution, which was advantageous when separating closely related anatomical structures (i.e. trabecular and compact bone, biomaterials). Fp-VCT facilitated imaging of alterations occurring in test specimens over time. fp-VCTs therefore displayed high volume coverage, dynamic imaging potential and superior performance when investigating superfine bone structures and bone remodelling of biomaterials. Thus, fp-VCTs may be a suitable instrument for intraoperative imaging and future in vivo tissue-engineering studies.
KW - Animals
KW - Apatites
KW - Autografts
KW - Bone Density
KW - Bone Remodeling
KW - Bone Substitutes
KW - Cell Culture Techniques
KW - Collagen
KW - Drug Combinations
KW - Image Processing, Computer-Assisted
KW - Imaging, Three-Dimensional
KW - Maxillary Sinus
KW - Multidetector Computed Tomography
KW - Osteoblasts
KW - Random Allocation
KW - Sheep
KW - Sinus Floor Augmentation
KW - Time Factors
KW - Tissue Engineering
KW - Tissue Scaffolds
KW - Tomography, X-Ray Computed
U2 - 10.1016/j.jcms.2012.11.039
DO - 10.1016/j.jcms.2012.11.039
M3 - SCORING: Journal article
C2 - 23332471
VL - 41
SP - e128-136
JO - J CRANIO MAXILL SURG
JF - J CRANIO MAXILL SURG
SN - 1010-5182
IS - 7
ER -
