Evaluation of a resistance-based model for the quantification of pulmonary arterial hypertension using MR flow measurements.
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Evaluation of a resistance-based model for the quantification of pulmonary arterial hypertension using MR flow measurements. / Abolmaali, Nasreddin; Seitz, Uwe; Esmaeili, Anoosh; Kock, Martin; Radeloff, Daniel; Ackermann, Hanns; Vogl, Thomas J.
in: J MAGN RESON IMAGING, Jahrgang 26, Nr. 3, 3, 2007, S. 646-653.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Evaluation of a resistance-based model for the quantification of pulmonary arterial hypertension using MR flow measurements.
AU - Abolmaali, Nasreddin
AU - Seitz, Uwe
AU - Esmaeili, Anoosh
AU - Kock, Martin
AU - Radeloff, Daniel
AU - Ackermann, Hanns
AU - Vogl, Thomas J
PY - 2007
Y1 - 2007
N2 - PURPOSE: To establish an estimate for the mean pulmonary arterial pressure (mPAP) derived from noninvasive data acquired with magnetic resonance (MR) velocity-encoded sequences. MATERIALS AND METHODS: In seven sedated pigs synchronous catheter-based invasive pressure measurements (IPM) and noninvasive MR were acquired in the main pulmonary artery (MPA) at different severities of pulmonary arterial hypertension (PAH) that were caused by infusion of thromboxane A2 (TxA2). The invasively measured mPAP was correlated with the noninvasive MR velocity data and linear combination equations (LCE) were computed. RESULTS: Intravenously applied TxA2 induced a dose dependent level of severity of PAH with an mPAP of up to 54 mmHg without systemic effects. The acceleration time (AT) measured with MR demonstrated the best correlation with the mPAP (r(2) = 0.75). The LCE with the highest correlation (R = 0.945, alpha <0.01) between IPM and MR revealed a mean difference of 0, a SD of s = 4.66 and a maximal difference of 12.2 mmHg using the Bland-Altman analysis. CONCLUSION: Applying the identified LCE allowed the estimation of the mPAP in an acute and resistance-based model of PAH with high accuracy using noninvasive MR velocity-encoded sequences.
AB - PURPOSE: To establish an estimate for the mean pulmonary arterial pressure (mPAP) derived from noninvasive data acquired with magnetic resonance (MR) velocity-encoded sequences. MATERIALS AND METHODS: In seven sedated pigs synchronous catheter-based invasive pressure measurements (IPM) and noninvasive MR were acquired in the main pulmonary artery (MPA) at different severities of pulmonary arterial hypertension (PAH) that were caused by infusion of thromboxane A2 (TxA2). The invasively measured mPAP was correlated with the noninvasive MR velocity data and linear combination equations (LCE) were computed. RESULTS: Intravenously applied TxA2 induced a dose dependent level of severity of PAH with an mPAP of up to 54 mmHg without systemic effects. The acceleration time (AT) measured with MR demonstrated the best correlation with the mPAP (r(2) = 0.75). The LCE with the highest correlation (R = 0.945, alpha <0.01) between IPM and MR revealed a mean difference of 0, a SD of s = 4.66 and a maximal difference of 12.2 mmHg using the Bland-Altman analysis. CONCLUSION: Applying the identified LCE allowed the estimation of the mPAP in an acute and resistance-based model of PAH with high accuracy using noninvasive MR velocity-encoded sequences.
M3 - SCORING: Zeitschriftenaufsatz
VL - 26
SP - 646
EP - 653
JO - J MAGN RESON IMAGING
JF - J MAGN RESON IMAGING
SN - 1053-1807
IS - 3
M1 - 3
ER -
