Ethnicity-specific differences in L-arginine status in South African men.
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Ethnicity-specific differences in L-arginine status in South African men. / Glyn, M C; Anderssohn, Maike; Lüneburg, Nicole; Van Rooyen, J M; Schutte, R; Huisman, H W; Fourie, C M T; Smith, W; Malan, L; Malan, N T; Mels, C M C; Böger, Rainer; Schutte, A E.
in: J HUM HYPERTENS, Jahrgang 26, Nr. 12, 12, 2012, S. 737-743.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Ethnicity-specific differences in L-arginine status in South African men.
AU - Glyn, M C
AU - Anderssohn, Maike
AU - Lüneburg, Nicole
AU - Van Rooyen, J M
AU - Schutte, R
AU - Huisman, H W
AU - Fourie, C M T
AU - Smith, W
AU - Malan, L
AU - Malan, N T
AU - Mels, C M C
AU - Böger, Rainer
AU - Schutte, A E
PY - 2012
Y1 - 2012
N2 - The aetiology for an increasing incidence of hypertensive cardiovascular disease amongst Africans in southern Africa is unclear. Hypertension may be induced by inadequate release of L-arginine-derived nitric oxide impairing vascular tone regulation. In addition, asymmetric dimethylarginine (ADMA) is associated with cardiovascular disease. We compared profiles of L-arginine in African and Caucasian men of similar age with cardiovascular risk factors. We studied 163 Caucasian and 132 African men, respectively, (20 to 70 years) measuring serum L-arginine, ADMA, creatinine, urea, symmetric dimethylarginine (SDMA) and blood pressure. L-arginine levels were significantly lower, whereas blood pressure and pulse wave velocity were significantly higher in African men. Simple linear regression showed ADMA more strongly associated with L-arginine in Caucasians (r=0.59 vs 0.19), whereas association of SDMA with L-arginine was significant only in Caucasians (r=0.43 vs 0.001). The stronger association of L-arginine with ADMA in Caucasian men was confirmed by multiple regression analysis (?=0.46 vs 0.25).Our findings show that the relationship of cardiovascular risk factors with serum L-arginine and some of its catabolites is different in African and Caucasian men and that this may be associated with a relatively higher prevalence of hypertension in African men.
AB - The aetiology for an increasing incidence of hypertensive cardiovascular disease amongst Africans in southern Africa is unclear. Hypertension may be induced by inadequate release of L-arginine-derived nitric oxide impairing vascular tone regulation. In addition, asymmetric dimethylarginine (ADMA) is associated with cardiovascular disease. We compared profiles of L-arginine in African and Caucasian men of similar age with cardiovascular risk factors. We studied 163 Caucasian and 132 African men, respectively, (20 to 70 years) measuring serum L-arginine, ADMA, creatinine, urea, symmetric dimethylarginine (SDMA) and blood pressure. L-arginine levels were significantly lower, whereas blood pressure and pulse wave velocity were significantly higher in African men. Simple linear regression showed ADMA more strongly associated with L-arginine in Caucasians (r=0.59 vs 0.19), whereas association of SDMA with L-arginine was significant only in Caucasians (r=0.43 vs 0.001). The stronger association of L-arginine with ADMA in Caucasian men was confirmed by multiple regression analysis (?=0.46 vs 0.25).Our findings show that the relationship of cardiovascular risk factors with serum L-arginine and some of its catabolites is different in African and Caucasian men and that this may be associated with a relatively higher prevalence of hypertension in African men.
M3 - SCORING: Journal article
VL - 26
SP - 737
EP - 743
JO - J HUM HYPERTENS
JF - J HUM HYPERTENS
SN - 0950-9240
IS - 12
M1 - 12
ER -
