Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry
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Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry. / Imori, Yoichi; Kato, Ken; Cammann, Victoria L; Szawan, Konrad A; Wischnewsky, Manfred; Dreiding, Sara; Würdinger, Michael; Schönberger, Maximilian; Petkova, Vanya; Niederseer, David; Levinson, Rena A; Di Vece, Davide; Gili, Sebastiano; Seifert, Burkhardt; Wakita, Masaki; Suzuki, Noriko; Citro, Rodolfo; Bossone, Eduardo; Heiner, Susanne; Knorr, Maike; Jansen, Thomas; Münzel, Thomas; D'Ascenzo, Fabrizio; Franke, Jennifer; Sorici-Barb, Ioana; Katus, Hugo A; Sarcon, Annahita; Shinbane, Jerold; Napp, L Christian; Bauersachs, Johann; Jaguszewski, Milosz; Shiomura, Reiko; Nakamura, Shunichi; Takano, Hitoshi; Noutsias, Michel; Burgdorf, Christof; Ishibashi, Iwao; Himi, Toshiharu; Koenig, Wolfgang; Schunkert, Heribert; Thiele, Holger; Kherad, Behrouz; Tschöpe, Carsten; Pieske, Burkert M; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Mizuno, Shingo; Cuneo, Alessandro; Jacobshagen, Claudius; Hasenfuß, Gerd; Karakas, Mahir; Mochizuki, Hiroki; Pott, Alexander; Rottbauer, Wolfgang; Said, Samir M; Braun-Dullaeus, Ruediger C; Banning, Adrian; Isogai, Toshiaki; Kimura, Akihisa; Cuculi, Florim; Kobza, Richard; Fischer, Thomas A; Vasankari, Tuija; Airaksinen, K E Juhani; Tomita, Yasuhiro; Budnik, Monika; Opolski, Grzegorz; Dworakowski, Rafal; MacCarthy, Philip; Kaiser, Christoph; Osswald, Stefan; Galiuto, Leonarda; Crea, Filippo; Dichtl, Wolfgang; Murakami, Tsutomu; Ikari, Yuji; Empen, Klaus; Beug, Daniel; Felix, Stephan B; Delmas, Clément; Lairez, Olivier; Yamaguchi, Tetsuo; El-Battrawy, Ibrahim; Akin, Ibrahim; Borggrefe, Martin; Horowitz, John D; Kozel, Martin; Tousek, Petr; Widimský, Petr; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; Neuhaus, Michael; Meyer, Philippe; Arroja, Jose David; Chan, Christina; Bridgman, Paul; Galuszka, Jan; Poglajen, Gregor; Carrilho-Ferreira, Pedro; Pinto, Fausto J; Hauck, Christian; Maier, Lars S; Liu, Kan; Di Mario, Carlo; Paolini, Carla; Bilato, Claudio; Bianco, Matteo; Jörg, Lucas; Rickli, Hans; Winchester, David E; Ukena, Christian; Böhm, Michael; Bax, Jeroen J; Prasad, Abhiram; Rihal, Charanjit S; Saito, Shigeru; Kobayashi, Yoshio; Lüscher, Thomas F; Ruschitzka, Frank; Shimizu, Wataru; Ghadri, Jelena R; Templin, Christian.
in: CLIN RES CARDIOL, Jahrgang 111, Nr. 2, 02.2022, S. 186-196.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry
AU - Imori, Yoichi
AU - Kato, Ken
AU - Cammann, Victoria L
AU - Szawan, Konrad A
AU - Wischnewsky, Manfred
AU - Dreiding, Sara
AU - Würdinger, Michael
AU - Schönberger, Maximilian
AU - Petkova, Vanya
AU - Niederseer, David
AU - Levinson, Rena A
AU - Di Vece, Davide
AU - Gili, Sebastiano
AU - Seifert, Burkhardt
AU - Wakita, Masaki
AU - Suzuki, Noriko
AU - Citro, Rodolfo
AU - Bossone, Eduardo
AU - Heiner, Susanne
AU - Knorr, Maike
AU - Jansen, Thomas
AU - Münzel, Thomas
AU - D'Ascenzo, Fabrizio
AU - Franke, Jennifer
AU - Sorici-Barb, Ioana
AU - Katus, Hugo A
AU - Sarcon, Annahita
AU - Shinbane, Jerold
AU - Napp, L Christian
AU - Bauersachs, Johann
AU - Jaguszewski, Milosz
AU - Shiomura, Reiko
AU - Nakamura, Shunichi
AU - Takano, Hitoshi
AU - Noutsias, Michel
AU - Burgdorf, Christof
AU - Ishibashi, Iwao
AU - Himi, Toshiharu
AU - Koenig, Wolfgang
AU - Schunkert, Heribert
AU - Thiele, Holger
AU - Kherad, Behrouz
AU - Tschöpe, Carsten
AU - Pieske, Burkert M
AU - Rajan, Lawrence
AU - Michels, Guido
AU - Pfister, Roman
AU - Mizuno, Shingo
AU - Cuneo, Alessandro
AU - Jacobshagen, Claudius
AU - Hasenfuß, Gerd
AU - Karakas, Mahir
AU - Mochizuki, Hiroki
AU - Pott, Alexander
AU - Rottbauer, Wolfgang
AU - Said, Samir M
AU - Braun-Dullaeus, Ruediger C
AU - Banning, Adrian
AU - Isogai, Toshiaki
AU - Kimura, Akihisa
AU - Cuculi, Florim
AU - Kobza, Richard
AU - Fischer, Thomas A
AU - Vasankari, Tuija
AU - Airaksinen, K E Juhani
AU - Tomita, Yasuhiro
AU - Budnik, Monika
AU - Opolski, Grzegorz
AU - Dworakowski, Rafal
AU - MacCarthy, Philip
AU - Kaiser, Christoph
AU - Osswald, Stefan
AU - Galiuto, Leonarda
AU - Crea, Filippo
AU - Dichtl, Wolfgang
AU - Murakami, Tsutomu
AU - Ikari, Yuji
AU - Empen, Klaus
AU - Beug, Daniel
AU - Felix, Stephan B
AU - Delmas, Clément
AU - Lairez, Olivier
AU - Yamaguchi, Tetsuo
AU - El-Battrawy, Ibrahim
AU - Akin, Ibrahim
AU - Borggrefe, Martin
AU - Horowitz, John D
AU - Kozel, Martin
AU - Tousek, Petr
AU - Widimský, Petr
AU - Gilyarova, Ekaterina
AU - Shilova, Alexandra
AU - Gilyarov, Mikhail
AU - Neuhaus, Michael
AU - Meyer, Philippe
AU - Arroja, Jose David
AU - Chan, Christina
AU - Bridgman, Paul
AU - Galuszka, Jan
AU - Poglajen, Gregor
AU - Carrilho-Ferreira, Pedro
AU - Pinto, Fausto J
AU - Hauck, Christian
AU - Maier, Lars S
AU - Liu, Kan
AU - Di Mario, Carlo
AU - Paolini, Carla
AU - Bilato, Claudio
AU - Bianco, Matteo
AU - Jörg, Lucas
AU - Rickli, Hans
AU - Winchester, David E
AU - Ukena, Christian
AU - Böhm, Michael
AU - Bax, Jeroen J
AU - Prasad, Abhiram
AU - Rihal, Charanjit S
AU - Saito, Shigeru
AU - Kobayashi, Yoshio
AU - Lüscher, Thomas F
AU - Ruschitzka, Frank
AU - Shimizu, Wataru
AU - Ghadri, Jelena R
AU - Templin, Christian
N1 - © 2021. The Author(s).
PY - 2022/2
Y1 - 2022/2
N2 - BACKGROUND: Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes.METHODS: TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients.RESULTS: A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 ± 11.4 years vs. 68.0 ± 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p < 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p < 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients.CONCLUSION: Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers.TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT01947621.
AB - BACKGROUND: Ethnic disparities have been reported in cardiovascular disease. However, ethnic disparities in takotsubo syndrome (TTS) remain elusive. This study assessed differences in clinical characteristics between Japanese and European TTS patients and determined the impact of ethnicity on in-hospital outcomes.METHODS: TTS patients in Japan were enrolled from 10 hospitals and TTS patients in Europe were enrolled from 32 hospitals participating in the International Takotsubo Registry. Clinical characteristics and in-hospital outcomes were compared between Japanese and European patients.RESULTS: A total of 503 Japanese and 1670 European patients were included. Japanese patients were older (72.6 ± 11.4 years vs. 68.0 ± 12.0 years; p < 0.001) and more likely to be male (18.5 vs. 8.4%; p < 0.001) than European TTS patients. Physical triggering factors were more common (45.5 vs. 32.0%; p < 0.001), and emotional triggers less common (17.5 vs. 31.5%; p < 0.001), in Japanese patients than in European patients. Japanese patients were more likely to experience cardiogenic shock during the acute phase (15.5 vs. 9.0%; p < 0.001) and had a higher in-hospital mortality (8.2 vs. 3.2%; p < 0.001). However, ethnicity itself did not appear to have an impact on in-hospital mortality. Machine learning approach revealed that the presence of physical stressors was the most important prognostic factor in both Japanese and European TTS patients.CONCLUSION: Differences in clinical characteristics and in-hospital outcomes between Japanese and European TTS patients exist. Ethnicity does not impact the outcome in TTS patients. The worse in-hospital outcome in Japanese patients, is mainly driven by the higher prevalence of physical triggers.TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique Identifier: NCT01947621.
KW - Aged
KW - Asian People/ethnology
KW - Europe/epidemiology
KW - Female
KW - Health Status Disparities
KW - Hospital Mortality/ethnology
KW - Humans
KW - Japan/epidemiology
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Registries
KW - Shock, Cardiogenic/ethnology
KW - Takotsubo Cardiomyopathy/ethnology
KW - White People/ethnology
U2 - 10.1007/s00392-021-01857-4
DO - 10.1007/s00392-021-01857-4
M3 - SCORING: Journal article
C2 - 34013386
VL - 111
SP - 186
EP - 196
JO - CLIN RES CARDIOL
JF - CLIN RES CARDIOL
SN - 1861-0684
IS - 2
ER -