Ethanol increases opioid activity in plasma of normal volunteers.
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Ethanol increases opioid activity in plasma of normal volunteers. / Naber, Dieter; Soble, M G; Pickar, D.
in: Pharmacopsychiatria, Jahrgang 14, Nr. 5, 5, 1981, S. 160-161.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Ethanol increases opioid activity in plasma of normal volunteers.
AU - Naber, Dieter
AU - Soble, M G
AU - Pickar, D
PY - 1981
Y1 - 1981
N2 - The effect of acute ethanol administration on plasma levels of beta-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptorassay, increased significantly with peak rises of more than 400%; levels of beta-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.
AB - The effect of acute ethanol administration on plasma levels of beta-endorphin-immunoreactivity and opioid activity was measured in 4 normal volunteers. 60 min following ethanol consumption opioid activity levels, measured by radioreceptorassay, increased significantly with peak rises of more than 400%; levels of beta-endorphin-immunoreactivity did not change significantly. These results are compatible with the effect of the opiate-antagonist naloxone, reversing ethanol-induced coma.
M3 - SCORING: Zeitschriftenaufsatz
VL - 14
SP - 160
EP - 161
IS - 5
M1 - 5
ER -