Estrogen receptor alpha expression in podocytes mediates protection against apoptosis in-vitro and in-vivo.

Sebastian Kummer; Stefanie Jeruschke; Lara Vanessa Wegerich; Andrea Peters; Petra Lehmann; Annette Seibt; Friederike Müller; Nadezda Koleganova; Elisabeth Halbenz; Claus Peter Schmitt; Markus Bettendorf; Ertan Mayatepek; Marie-Luise Gross-Weissmann; Jun Oh

doi:10.1371/journal.pone.0027457

Estrogen receptor alpha expression in podocytes mediates protection against apoptosis in-vitro and in-vivo.

Sebastian Kummer
Stefanie Jeruschke
Lara Vanessa Wegerich
Andrea Peters
Petra Lehmann
Annette Seibt
Friederike Müller
Nadezda Koleganova
Elisabeth Halbenz
Claus Peter Schmitt
Markus Bettendorf
Ertan Mayatepek
Marie-Luise Gross-Weissmann
Jun Oh

Beteiligte Einrichtungen

Klinik und Poliklinik für Kinder- und Jugendmedizin

Abstract

Epidemiological studies have demonstrated that women have a significantly better prognosis in chronic renal diseases compared to men. This suggests critical influences of gender hormones on glomerular structure and function. We examined potential direct protective effects of estradiol on podocytes.

Bibliografische Daten

Originalsprache	Englisch
Aufsatznummer	11
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0027457
Status	Veröffentlicht - 2011

pubmed	22096576