PortalPublikationenEstimating vaccine effectiveness against laboratory-confirme...

Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016

Standard

Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016. / Möhl, A; Gräfe, L; Helmeke, C; Ziehm, D; Monazahian, M; Irmscher, H-M; Dreesman, J.

in: EPIDEMIOL INFECT, Jahrgang 146, Nr. 1, 01.2018, S. 78-88.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Möhl, A, Gräfe, L, Helmeke, C, Ziehm, D, Monazahian, M, Irmscher, H-M & Dreesman, J 2018, 'Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016', EPIDEMIOL INFECT, Jg. 146, Nr. 1, S. 78-88. https://doi.org/10.1017/S0950268817002709

APA

Möhl, A., Gräfe, L., Helmeke, C., Ziehm, D., Monazahian, M., Irmscher, H-M., & Dreesman, J. (2018). Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016. EPIDEMIOL INFECT, 146(1), 78-88. https://doi.org/10.1017/S0950268817002709

Vancouver

Möhl A, Gräfe L, Helmeke C, Ziehm D, Monazahian M, Irmscher H-M et al. Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016. EPIDEMIOL INFECT. 2018 Jan;146(1):78-88. https://doi.org/10.1017/S0950268817002709

Bibtex

@article{25fbb4a83f0647d6a7785d2dc97461a4,
title = "Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016",
abstract = "Influenza vaccine effectiveness (VE) has to be estimated anew for every season to explore vaccines' protective effect in the population. We report VE estimates against laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2) and influenza B among children aged 2-17 years, using test-negative design. Pooled data from two German federal states' surveillance systems for acute respiratory illness from week 40/2012 to 20/2016 was used, yielding a total of 10 627 specimens. Odds ratios and 95% confidence intervals (95% CIs) for the association between laboratory-confirmed influenza and vaccination status were calculated by multivariate logistic regression adjusting for age, sex, illness onset and federal state. VE was estimated as 1-Odds Ratio. Overall adjusted VE was 33% (95% CI: 24·3-40·7). A strong variation of VE between the seasons and subtypes was observed: highest season- and subtype-specific VE of 86·2% (95% CI: 41·3-96·7) was found against A(H1N1)pdm09 in 7-17-year-olds in 2015/16. Low estimates of VE were observed against A(H3N2) in any season, e.g. 1·5% (95% CI: -39·3-30·3) in 2014/15. Estimates showed a tendency to higher VE among 7-17-year-old children, but differences were not statistically significant. Although our findings are common in studies estimating influenza VE, we discussed several explanations for observed low VE.",
keywords = "Adolescent, Child, Child, Preschool, Female, Germany, Humans, Infant, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Influenza B virus, Influenza Vaccines, Influenza, Human, Logistic Models, Male, Seasons, Sentinel Surveillance, Journal Article",
author = "A M{\"o}hl and L Gr{\"a}fe and C Helmeke and D Ziehm and M Monazahian and H-M Irmscher and J Dreesman",
year = "2018",
month = jan,
doi = "10.1017/S0950268817002709",
language = "English",
volume = "146",
pages = "78--88",
journal = "EPIDEMIOL INFECT",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "1",

}

RIS

TY - JOUR

T1 - Estimating vaccine effectiveness against laboratory-confirmed influenza among children and adolescents in Lower Saxony and Saxony-Anhalt, 2012-2016

AU - Möhl, A

AU - Gräfe, L

AU - Helmeke, C

AU - Ziehm, D

AU - Monazahian, M

AU - Irmscher, H-M

AU - Dreesman, J

PY - 2018/1

Y1 - 2018/1

N2 - Influenza vaccine effectiveness (VE) has to be estimated anew for every season to explore vaccines' protective effect in the population. We report VE estimates against laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2) and influenza B among children aged 2-17 years, using test-negative design. Pooled data from two German federal states' surveillance systems for acute respiratory illness from week 40/2012 to 20/2016 was used, yielding a total of 10 627 specimens. Odds ratios and 95% confidence intervals (95% CIs) for the association between laboratory-confirmed influenza and vaccination status were calculated by multivariate logistic regression adjusting for age, sex, illness onset and federal state. VE was estimated as 1-Odds Ratio. Overall adjusted VE was 33% (95% CI: 24·3-40·7). A strong variation of VE between the seasons and subtypes was observed: highest season- and subtype-specific VE of 86·2% (95% CI: 41·3-96·7) was found against A(H1N1)pdm09 in 7-17-year-olds in 2015/16. Low estimates of VE were observed against A(H3N2) in any season, e.g. 1·5% (95% CI: -39·3-30·3) in 2014/15. Estimates showed a tendency to higher VE among 7-17-year-old children, but differences were not statistically significant. Although our findings are common in studies estimating influenza VE, we discussed several explanations for observed low VE.

AB - Influenza vaccine effectiveness (VE) has to be estimated anew for every season to explore vaccines' protective effect in the population. We report VE estimates against laboratory-confirmed influenza A(H1N1)pdm09, A(H3N2) and influenza B among children aged 2-17 years, using test-negative design. Pooled data from two German federal states' surveillance systems for acute respiratory illness from week 40/2012 to 20/2016 was used, yielding a total of 10 627 specimens. Odds ratios and 95% confidence intervals (95% CIs) for the association between laboratory-confirmed influenza and vaccination status were calculated by multivariate logistic regression adjusting for age, sex, illness onset and federal state. VE was estimated as 1-Odds Ratio. Overall adjusted VE was 33% (95% CI: 24·3-40·7). A strong variation of VE between the seasons and subtypes was observed: highest season- and subtype-specific VE of 86·2% (95% CI: 41·3-96·7) was found against A(H1N1)pdm09 in 7-17-year-olds in 2015/16. Low estimates of VE were observed against A(H3N2) in any season, e.g. 1·5% (95% CI: -39·3-30·3) in 2014/15. Estimates showed a tendency to higher VE among 7-17-year-old children, but differences were not statistically significant. Although our findings are common in studies estimating influenza VE, we discussed several explanations for observed low VE.

KW - Adolescent

KW - Child

KW - Child, Preschool

KW - Female

KW - Germany

KW - Humans

KW - Infant

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza A Virus, H3N2 Subtype

KW - Influenza B virus

KW - Influenza Vaccines

KW - Influenza, Human

KW - Logistic Models

KW - Male

KW - Seasons

KW - Sentinel Surveillance

KW - Journal Article

U2 - 10.1017/S0950268817002709

DO - 10.1017/S0950268817002709

M3 - SCORING: Journal article

C2 - 29208075

VL - 146

SP - 78

EP - 88

JO - EPIDEMIOL INFECT

JF - EPIDEMIOL INFECT

SN - 0950-2688

IS - 1

ER -