Establishment of tissue-resident immune populations in the fetus

Dorien Feyaerts; Christopher Urbschat; Brice Gaudillière; Ina A Stelzer

doi:10.1007/s00281-022-00931-x

Establishment of tissue-resident immune populations in the fetus

Standard

Establishment of tissue-resident immune populations in the fetus. / Feyaerts, Dorien; Urbschat, Christopher; Gaudillière, Brice; Stelzer, Ina A.

in: SEMIN IMMUNOPATHOL, Jahrgang 44, Nr. 6, 11.2022, S. 747-766.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung

Harvard

Feyaerts, D, Urbschat, C, Gaudillière, B & Stelzer, IA 2022, 'Establishment of tissue-resident immune populations in the fetus', SEMIN IMMUNOPATHOL, Jg. 44, Nr. 6, S. 747-766. https://doi.org/10.1007/s00281-022-00931-x

APA

Feyaerts, D., Urbschat, C., Gaudillière, B., & Stelzer, I. A. (2022). Establishment of tissue-resident immune populations in the fetus. SEMIN IMMUNOPATHOL, 44(6), 747-766. https://doi.org/10.1007/s00281-022-00931-x

Vancouver

Feyaerts D, Urbschat C, Gaudillière B, Stelzer IA. Establishment of tissue-resident immune populations in the fetus. SEMIN IMMUNOPATHOL. 2022 Nov;44(6):747-766. https://doi.org/10.1007/s00281-022-00931-x

Bibtex

@article{d09be19b34be427d9278545408bf75e3,

title = "Establishment of tissue-resident immune populations in the fetus",

abstract = "The immune system establishes during the prenatal period from distinct waves of stem and progenitor cells and continuously adapts to the needs and challenges of early postnatal and adult life. Fetal immune development not only lays the foundation for postnatal immunity but establishes functional populations of tissue-resident immune cells that are instrumental for fetal immune responses amidst organ growth and maturation. This review aims to discuss current knowledge about the development and function of tissue-resident immune populations during fetal life, focusing on the brain, lung, and gastrointestinal tract as sites with distinct developmental trajectories. While recent progress using system-level approaches has shed light on the fetal immune landscape, further work is required to describe precise roles of prenatal immune populations and their migration and adaptation to respective organ environments. Defining points of prenatal susceptibility to environmental challenges will support the search for potential therapeutic targets to positively impact postnatal health.",

author = "Dorien Feyaerts and Christopher Urbschat and Brice Gaudilli{\`e}re and Stelzer, {Ina A}",

note = "{\textcopyright} 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.",

year = "2022",

month = nov,

doi = "10.1007/s00281-022-00931-x",

language = "English",

volume = "44",

pages = "747--766",

journal = "SEMIN IMMUNOPATHOL",

issn = "1863-2297",

publisher = "Springer",

number = "6",

}

RIS

TY - JOUR

T1 - Establishment of tissue-resident immune populations in the fetus

AU - Feyaerts, Dorien

AU - Urbschat, Christopher

AU - Gaudillière, Brice

AU - Stelzer, Ina A

PY - 2022/11

Y1 - 2022/11

N2 - The immune system establishes during the prenatal period from distinct waves of stem and progenitor cells and continuously adapts to the needs and challenges of early postnatal and adult life. Fetal immune development not only lays the foundation for postnatal immunity but establishes functional populations of tissue-resident immune cells that are instrumental for fetal immune responses amidst organ growth and maturation. This review aims to discuss current knowledge about the development and function of tissue-resident immune populations during fetal life, focusing on the brain, lung, and gastrointestinal tract as sites with distinct developmental trajectories. While recent progress using system-level approaches has shed light on the fetal immune landscape, further work is required to describe precise roles of prenatal immune populations and their migration and adaptation to respective organ environments. Defining points of prenatal susceptibility to environmental challenges will support the search for potential therapeutic targets to positively impact postnatal health.

AB - The immune system establishes during the prenatal period from distinct waves of stem and progenitor cells and continuously adapts to the needs and challenges of early postnatal and adult life. Fetal immune development not only lays the foundation for postnatal immunity but establishes functional populations of tissue-resident immune cells that are instrumental for fetal immune responses amidst organ growth and maturation. This review aims to discuss current knowledge about the development and function of tissue-resident immune populations during fetal life, focusing on the brain, lung, and gastrointestinal tract as sites with distinct developmental trajectories. While recent progress using system-level approaches has shed light on the fetal immune landscape, further work is required to describe precise roles of prenatal immune populations and their migration and adaptation to respective organ environments. Defining points of prenatal susceptibility to environmental challenges will support the search for potential therapeutic targets to positively impact postnatal health.

U2 - 10.1007/s00281-022-00931-x

DO - 10.1007/s00281-022-00931-x

M3 - SCORING: Review article

C2 - 35508672

VL - 44

SP - 747

EP - 766

JO - SEMIN IMMUNOPATHOL

JF - SEMIN IMMUNOPATHOL

SN - 1863-2297

IS - 6

ER -