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Essential role of RSK2 in c-Fos-dependent osteosarcoma development.

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Essential role of RSK2 in c-Fos-dependent osteosarcoma development. / David, Jean-Pierre; Mehic, Denis; Bakiri, Latifa; Schilling, Arndt; Mandic, Vice; Priemel, Matthias; Idarraga, Maria Helena; Reschke, Markus O; Hoffmann, Oskar; Amling, Michael; Wagner, Erwin F.

in: J CLIN INVEST, Jahrgang 115, Nr. 3, 3, 2005, S. 664-672.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

David, J-P, Mehic, D, Bakiri, L, Schilling, A, Mandic, V, Priemel, M, Idarraga, MH, Reschke, MO, Hoffmann, O, Amling, M & Wagner, EF 2005, 'Essential role of RSK2 in c-Fos-dependent osteosarcoma development.', J CLIN INVEST, Jg. 115, Nr. 3, 3, S. 664-672. <http://www.ncbi.nlm.nih.gov/pubmed/15719069?dopt=Citation>

APA

David, J-P., Mehic, D., Bakiri, L., Schilling, A., Mandic, V., Priemel, M., Idarraga, M. H., Reschke, M. O., Hoffmann, O., Amling, M., & Wagner, E. F. (2005). Essential role of RSK2 in c-Fos-dependent osteosarcoma development. J CLIN INVEST, 115(3), 664-672. [3]. http://www.ncbi.nlm.nih.gov/pubmed/15719069?dopt=Citation

Vancouver

David J-P, Mehic D, Bakiri L, Schilling A, Mandic V, Priemel M et al. Essential role of RSK2 in c-Fos-dependent osteosarcoma development. J CLIN INVEST. 2005;115(3):664-672. 3.

Bibtex

@article{c4d7c94cf9034a77b34f4635f4589232,
title = "Essential role of RSK2 in c-Fos-dependent osteosarcoma development.",
abstract = "Inactivation of the growth factor-regulated S6 kinase RSK2 causes Coffin-Lowry syndrome in humans, an X-linked mental retardation condition associated with progressive skeletal abnormalities. Here we show that mice lacking RSK2 develop a progressive skeletal disease, osteopenia due to impaired osteoblast function and normal osteoclast differentiation. The phenotype is associated with decreased expression of Phex, an endopeptidase regulating bone mineralization. This defect is probably not mediated by RSK2-dependent phosphorylation of c-Fos on serine 362 in the C-terminus. However, in the absence of RSK2, c-Fos-dependent osteosarcoma formation is impaired. The lack of c-Fos phosphorylation leads to reduced c-Fos protein levels, which are thought to be responsible for decreased proliferation and increased apoptosis of transformed osteoblasts. Therefore, RSK2-dependent stabilization of c-Fos is essential for osteosarcoma formation in mice and may also be important for human osteosarcomas.",
author = "Jean-Pierre David and Denis Mehic and Latifa Bakiri and Arndt Schilling and Vice Mandic and Matthias Priemel and Idarraga, {Maria Helena} and Reschke, {Markus O} and Oskar Hoffmann and Michael Amling and Wagner, {Erwin F}",
year = "2005",
language = "Deutsch",
volume = "115",
pages = "664--672",
journal = "J CLIN INVEST",
issn = "0021-9738",
publisher = "The American Society for Clinical Investigation",
number = "3",

}

RIS

TY - JOUR

T1 - Essential role of RSK2 in c-Fos-dependent osteosarcoma development.

AU - David, Jean-Pierre

AU - Mehic, Denis

AU - Bakiri, Latifa

AU - Schilling, Arndt

AU - Mandic, Vice

AU - Priemel, Matthias

AU - Idarraga, Maria Helena

AU - Reschke, Markus O

AU - Hoffmann, Oskar

AU - Amling, Michael

AU - Wagner, Erwin F

PY - 2005

Y1 - 2005

N2 - Inactivation of the growth factor-regulated S6 kinase RSK2 causes Coffin-Lowry syndrome in humans, an X-linked mental retardation condition associated with progressive skeletal abnormalities. Here we show that mice lacking RSK2 develop a progressive skeletal disease, osteopenia due to impaired osteoblast function and normal osteoclast differentiation. The phenotype is associated with decreased expression of Phex, an endopeptidase regulating bone mineralization. This defect is probably not mediated by RSK2-dependent phosphorylation of c-Fos on serine 362 in the C-terminus. However, in the absence of RSK2, c-Fos-dependent osteosarcoma formation is impaired. The lack of c-Fos phosphorylation leads to reduced c-Fos protein levels, which are thought to be responsible for decreased proliferation and increased apoptosis of transformed osteoblasts. Therefore, RSK2-dependent stabilization of c-Fos is essential for osteosarcoma formation in mice and may also be important for human osteosarcomas.

AB - Inactivation of the growth factor-regulated S6 kinase RSK2 causes Coffin-Lowry syndrome in humans, an X-linked mental retardation condition associated with progressive skeletal abnormalities. Here we show that mice lacking RSK2 develop a progressive skeletal disease, osteopenia due to impaired osteoblast function and normal osteoclast differentiation. The phenotype is associated with decreased expression of Phex, an endopeptidase regulating bone mineralization. This defect is probably not mediated by RSK2-dependent phosphorylation of c-Fos on serine 362 in the C-terminus. However, in the absence of RSK2, c-Fos-dependent osteosarcoma formation is impaired. The lack of c-Fos phosphorylation leads to reduced c-Fos protein levels, which are thought to be responsible for decreased proliferation and increased apoptosis of transformed osteoblasts. Therefore, RSK2-dependent stabilization of c-Fos is essential for osteosarcoma formation in mice and may also be important for human osteosarcomas.

M3 - SCORING: Zeitschriftenaufsatz

VL - 115

SP - 664

EP - 672

JO - J CLIN INVEST

JF - J CLIN INVEST

SN - 0021-9738

IS - 3

M1 - 3

ER -