Esophageal Cancer Specific Risk Score Is Associated with Postoperative Complications Following Open Ivor-Lewis Esophagectomy for Adenocarcinoma

Kirsten Lindner; Daniel Palmes; Amelie Grübener; Norbert Senninger; Jörg Haier; Richard Hummel

doi:10.1159/000439442

Esophageal Cancer Specific Risk Score Is Associated with Postoperative Complications Following Open Ivor-Lewis Esophagectomy for Adenocarcinoma

Standard

Esophageal Cancer Specific Risk Score Is Associated with Postoperative Complications Following Open Ivor-Lewis Esophagectomy for Adenocarcinoma. / Lindner, Kirsten; Palmes, Daniel; Grübener, Amelie; Senninger, Norbert; Haier, Jörg; Hummel, Richard.

in: DIGEST SURG, Jahrgang 33, Nr. 1, 2016, S. 58-65.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Lindner, K, Palmes, D, Grübener, A, Senninger, N, Haier, J & Hummel, R 2016, 'Esophageal Cancer Specific Risk Score Is Associated with Postoperative Complications Following Open Ivor-Lewis Esophagectomy for Adenocarcinoma', DIGEST SURG, Jg. 33, Nr. 1, S. 58-65. https://doi.org/10.1159/000439442

APA

Lindner, K., Palmes, D., Grübener, A., Senninger, N., Haier, J., & Hummel, R. (2016). Esophageal Cancer Specific Risk Score Is Associated with Postoperative Complications Following Open Ivor-Lewis Esophagectomy for Adenocarcinoma. DIGEST SURG, 33(1), 58-65. https://doi.org/10.1159/000439442

Vancouver

Lindner K, Palmes D, Grübener A, Senninger N, Haier J, Hummel R. Esophageal Cancer Specific Risk Score Is Associated with Postoperative Complications Following Open Ivor-Lewis Esophagectomy for Adenocarcinoma. DIGEST SURG. 2016;33(1):58-65. https://doi.org/10.1159/000439442

Bibtex

@article{84a2f1441fc047f49b5653cf630e1ac9,

title = "Esophageal Cancer Specific Risk Score Is Associated with Postoperative Complications Following Open Ivor-Lewis Esophagectomy for Adenocarcinoma",

abstract = "BACKGROUND/AIMS: Surgery for esophageal cancer is associated with a high morbidity and mortality. With this study, we investigated if a validated preoperative risk score correlates with overall morbidity, mortality, anastomotic insufficiency, respiratory complications and with the severity of complications after open Ivor-Lewis esophagectomy.METHODS: A total of 94 patients undergoing esophageal resection for adenocarcinoma between 2005 and 2009 were included. Patients were assigned using the preoperative risk score according to Schr{\"o}der et al. [Langenbecks Arch Surg 2006;391:455-460] and the Dindo classification regarding the severity of complications.RESULTS: Of all the patients, 12% had a 'normal', 54% a 'moderate' and 34% a 'high' preoperative risk score. Postoperative complications occurred in 79%. Furthermore, 36 or 21 or 14 or 7% of patients experienced complications of category I/II or III or IV or V, respectively. There was a significant association between preoperative risk score and overall morbidity (p = 0.010), mortality (p = 0.035) and anastomotic insufficiency (p = 0.023). Furthermore, higher preoperative risk score was significant related to increasing severity of postoperative complications (grade IV according to the Dindo classification: p = 0.018, Dindo grade V: p = 0.035). Neoadjuvant therapy consisting of cisplatin and 5-fluorouracil had no influence.CONCLUSION: As we demonstrated, a significant association between preoperative risk score and occurrence and severity of postoperative complications after open Ivor-Lewis esophagectomy, standardized, organ-specific pre- and postoperative categorizations might be useful for individual clinical decision making in this group of patients.",

author = "Kirsten Lindner and Daniel Palmes and Amelie Gr{\"u}bener and Norbert Senninger and J{\"o}rg Haier and Richard Hummel",

note = "{\textcopyright} 2015 S. Karger AG, Basel.",

year = "2016",

doi = "10.1159/000439442",

language = "English",

volume = "33",

pages = "58--65",

journal = "DIGEST SURG",

issn = "0253-4886",

publisher = "S. Karger AG",

number = "1",

}

RIS

TY - JOUR

T1 - Esophageal Cancer Specific Risk Score Is Associated with Postoperative Complications Following Open Ivor-Lewis Esophagectomy for Adenocarcinoma

AU - Lindner, Kirsten

AU - Palmes, Daniel

AU - Grübener, Amelie

AU - Senninger, Norbert

AU - Haier, Jörg

AU - Hummel, Richard

PY - 2016

Y1 - 2016

N2 - BACKGROUND/AIMS: Surgery for esophageal cancer is associated with a high morbidity and mortality. With this study, we investigated if a validated preoperative risk score correlates with overall morbidity, mortality, anastomotic insufficiency, respiratory complications and with the severity of complications after open Ivor-Lewis esophagectomy.METHODS: A total of 94 patients undergoing esophageal resection for adenocarcinoma between 2005 and 2009 were included. Patients were assigned using the preoperative risk score according to Schröder et al. [Langenbecks Arch Surg 2006;391:455-460] and the Dindo classification regarding the severity of complications.RESULTS: Of all the patients, 12% had a 'normal', 54% a 'moderate' and 34% a 'high' preoperative risk score. Postoperative complications occurred in 79%. Furthermore, 36 or 21 or 14 or 7% of patients experienced complications of category I/II or III or IV or V, respectively. There was a significant association between preoperative risk score and overall morbidity (p = 0.010), mortality (p = 0.035) and anastomotic insufficiency (p = 0.023). Furthermore, higher preoperative risk score was significant related to increasing severity of postoperative complications (grade IV according to the Dindo classification: p = 0.018, Dindo grade V: p = 0.035). Neoadjuvant therapy consisting of cisplatin and 5-fluorouracil had no influence.CONCLUSION: As we demonstrated, a significant association between preoperative risk score and occurrence and severity of postoperative complications after open Ivor-Lewis esophagectomy, standardized, organ-specific pre- and postoperative categorizations might be useful for individual clinical decision making in this group of patients.

AB - BACKGROUND/AIMS: Surgery for esophageal cancer is associated with a high morbidity and mortality. With this study, we investigated if a validated preoperative risk score correlates with overall morbidity, mortality, anastomotic insufficiency, respiratory complications and with the severity of complications after open Ivor-Lewis esophagectomy.METHODS: A total of 94 patients undergoing esophageal resection for adenocarcinoma between 2005 and 2009 were included. Patients were assigned using the preoperative risk score according to Schröder et al. [Langenbecks Arch Surg 2006;391:455-460] and the Dindo classification regarding the severity of complications.RESULTS: Of all the patients, 12% had a 'normal', 54% a 'moderate' and 34% a 'high' preoperative risk score. Postoperative complications occurred in 79%. Furthermore, 36 or 21 or 14 or 7% of patients experienced complications of category I/II or III or IV or V, respectively. There was a significant association between preoperative risk score and overall morbidity (p = 0.010), mortality (p = 0.035) and anastomotic insufficiency (p = 0.023). Furthermore, higher preoperative risk score was significant related to increasing severity of postoperative complications (grade IV according to the Dindo classification: p = 0.018, Dindo grade V: p = 0.035). Neoadjuvant therapy consisting of cisplatin and 5-fluorouracil had no influence.CONCLUSION: As we demonstrated, a significant association between preoperative risk score and occurrence and severity of postoperative complications after open Ivor-Lewis esophagectomy, standardized, organ-specific pre- and postoperative categorizations might be useful for individual clinical decision making in this group of patients.

U2 - 10.1159/000439442

DO - 10.1159/000439442

M3 - SCORING: Journal article

C2 - 26600155

VL - 33

SP - 58

EP - 65

JO - DIGEST SURG

JF - DIGEST SURG

SN - 0253-4886

IS - 1

ER -