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Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma

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Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma. / Friedrich, Reinhard E; Bartel-Friedrich, Sylva; Lobeck, Hartmut; Niedobitek, Gerald; Arps, Hartmut.

in: MED MICROBIOL IMMUN, Jahrgang 192, Nr. 3, 01.08.2003, S. 141-4.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Friedrich, RE, Bartel-Friedrich, S, Lobeck, H, Niedobitek, G & Arps, H 2003, 'Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma', MED MICROBIOL IMMUN, Jg. 192, Nr. 3, S. 141-4. https://doi.org/10.1007/s00430-002-0134-1

APA

Friedrich, R. E., Bartel-Friedrich, S., Lobeck, H., Niedobitek, G., & Arps, H. (2003). Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma. MED MICROBIOL IMMUN, 192(3), 141-4. https://doi.org/10.1007/s00430-002-0134-1

Vancouver

Friedrich RE, Bartel-Friedrich S, Lobeck H, Niedobitek G, Arps H. Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma. MED MICROBIOL IMMUN. 2003 Aug 1;192(3):141-4. https://doi.org/10.1007/s00430-002-0134-1

Bibtex

@article{13171bbf0c1f49e5b6b7ab89962c18ec,
title = "Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma",
abstract = "Nasopharyngeal carcinoma (NPC) belongs to the most common malignant tumours in certain parts of the world, e.g. South-East Asia. The undifferentiated type of NPC is associated with genomic Epstein-Barr virus (EBV) DNA. In normal epithelia of the nasopharynx cytokeratins (CK) 4, 5, 6, 13, 14, 15 and 19 are expressed. The aim of this study was to analyse the expression pattern of cytokeratins in NPC in the presence of EBV infection. Twenty primary or metastatic tumours from 13 patients suffering from a NPC were evaluated (formalin-fixed, paraffin-embedded). (35)S-labelled probes were used to detect EBV DNA in the tissue sections. Fourteen specimens (70%) were EBV positive. All positive specimens were undifferentiated NPC. All NPC were identified with broad-spectrum anti-CK antibody. Using a panel of anti-CK antibodies, there was no specific CK-expression pattern in NPC. In summary, undifferentiated NPC are strongly associated with EBV. The cytoskeleton of undifferentiated NPC reveals no specific pattern of CK expression.",
keywords = "Adult, Aged, DNA Probes, DNA, Viral, Female, Herpesvirus 4, Human, Humans, In Situ Hybridization, Keratins, Male, Middle Aged, Nasopharyngeal Neoplasms",
author = "Friedrich, {Reinhard E} and Sylva Bartel-Friedrich and Hartmut Lobeck and Gerald Niedobitek and Hartmut Arps",
year = "2003",
month = aug,
day = "1",
doi = "10.1007/s00430-002-0134-1",
language = "English",
volume = "192",
pages = "141--4",
journal = "MED MICROBIOL IMMUN",
issn = "0300-8584",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Epstein-Barr virus DNA and epithelial markers in nasopharyngeal carcinoma

AU - Friedrich, Reinhard E

AU - Bartel-Friedrich, Sylva

AU - Lobeck, Hartmut

AU - Niedobitek, Gerald

AU - Arps, Hartmut

PY - 2003/8/1

Y1 - 2003/8/1

N2 - Nasopharyngeal carcinoma (NPC) belongs to the most common malignant tumours in certain parts of the world, e.g. South-East Asia. The undifferentiated type of NPC is associated with genomic Epstein-Barr virus (EBV) DNA. In normal epithelia of the nasopharynx cytokeratins (CK) 4, 5, 6, 13, 14, 15 and 19 are expressed. The aim of this study was to analyse the expression pattern of cytokeratins in NPC in the presence of EBV infection. Twenty primary or metastatic tumours from 13 patients suffering from a NPC were evaluated (formalin-fixed, paraffin-embedded). (35)S-labelled probes were used to detect EBV DNA in the tissue sections. Fourteen specimens (70%) were EBV positive. All positive specimens were undifferentiated NPC. All NPC were identified with broad-spectrum anti-CK antibody. Using a panel of anti-CK antibodies, there was no specific CK-expression pattern in NPC. In summary, undifferentiated NPC are strongly associated with EBV. The cytoskeleton of undifferentiated NPC reveals no specific pattern of CK expression.

AB - Nasopharyngeal carcinoma (NPC) belongs to the most common malignant tumours in certain parts of the world, e.g. South-East Asia. The undifferentiated type of NPC is associated with genomic Epstein-Barr virus (EBV) DNA. In normal epithelia of the nasopharynx cytokeratins (CK) 4, 5, 6, 13, 14, 15 and 19 are expressed. The aim of this study was to analyse the expression pattern of cytokeratins in NPC in the presence of EBV infection. Twenty primary or metastatic tumours from 13 patients suffering from a NPC were evaluated (formalin-fixed, paraffin-embedded). (35)S-labelled probes were used to detect EBV DNA in the tissue sections. Fourteen specimens (70%) were EBV positive. All positive specimens were undifferentiated NPC. All NPC were identified with broad-spectrum anti-CK antibody. Using a panel of anti-CK antibodies, there was no specific CK-expression pattern in NPC. In summary, undifferentiated NPC are strongly associated with EBV. The cytoskeleton of undifferentiated NPC reveals no specific pattern of CK expression.

KW - Adult

KW - Aged

KW - DNA Probes

KW - DNA, Viral

KW - Female

KW - Herpesvirus 4, Human

KW - Humans

KW - In Situ Hybridization

KW - Keratins

KW - Male

KW - Middle Aged

KW - Nasopharyngeal Neoplasms

U2 - 10.1007/s00430-002-0134-1

DO - 10.1007/s00430-002-0134-1

M3 - SCORING: Journal article

C2 - 12920589

VL - 192

SP - 141

EP - 144

JO - MED MICROBIOL IMMUN

JF - MED MICROBIOL IMMUN

SN - 0300-8584

IS - 3

ER -