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EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration.

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EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration. / Nagakane, Yoshinari; Christensen, Soren; Brekenfeld, Caspar; Ma, Henry; Churilov, Leonid; Parsons, Mark W; Levi, Christopher R; Butcher, Kenneth S; Peeters, Andre; Barber, P Alan; Bladin, Christopher F; Silva, De; Deidre, A; Fink, John; Kimber, Thomas E; Schultz, David W; Muir, Keith W; Tress, Brian M; Desmond, Patricia M; Davis, Stephen M; Donnan, Geoffrey A; Investigators, EPITHET.

in: STROKE, Jahrgang 42, Nr. 1, 1, 2011, S. 59-64.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Nagakane, Y, Christensen, S, Brekenfeld, C, Ma, H, Churilov, L, Parsons, MW, Levi, CR, Butcher, KS, Peeters, A, Barber, PA, Bladin, CF, Silva, D, Deidre, A, Fink, J, Kimber, TE, Schultz, DW, Muir, KW, Tress, BM, Desmond, PM, Davis, SM, Donnan, GA & Investigators, EPITHET 2011, 'EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration.', STROKE, Jg. 42, Nr. 1, 1, S. 59-64. <http://www.ncbi.nlm.nih.gov/pubmed/21127303?dopt=Citation>

APA

Nagakane, Y., Christensen, S., Brekenfeld, C., Ma, H., Churilov, L., Parsons, M. W., Levi, C. R., Butcher, K. S., Peeters, A., Barber, P. A., Bladin, C. F., Silva, D., Deidre, A., Fink, J., Kimber, T. E., Schultz, D. W., Muir, K. W., Tress, B. M., Desmond, P. M., ... Investigators, EPITHET. (2011). EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration. STROKE, 42(1), 59-64. [1]. http://www.ncbi.nlm.nih.gov/pubmed/21127303?dopt=Citation

Vancouver

Nagakane Y, Christensen S, Brekenfeld C, Ma H, Churilov L, Parsons MW et al. EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration. STROKE. 2011;42(1):59-64. 1.

Bibtex

@article{2fccb728b56e40ab9247c1a1ff5745a2,
title = "EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration.",
abstract = "the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) was a prospective, randomized, double-blinded, placebo-controlled, phase II trial of alteplase between 3 and 6 hours after stroke onset. The primary outcome of infarct growth attenuation on MRI with alteplase in mismatch patients was negative when mismatch volumes were assessed volumetrically, without coregistration, which underestimates mismatch volumes. We hypothesized that assessing the extent of mismatch by coregistration of perfusion and diffusion MRI maps may more accurately allow the effects of alteplase vs placebo to be evaluated.",
keywords = "Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Time Factors, *Diffusion Magnetic Resonance Imaging, Brain Infarction/*drug therapy/metabolism/*radiography, Fibrinolytic Agents/*administration & dosage, Tissue Plasminogen Activator/*administration & dosage, Humans, Male, Aged, Female, Middle Aged, Aged, 80 and over, Time Factors, *Diffusion Magnetic Resonance Imaging, Brain Infarction/*drug therapy/metabolism/*radiography, Fibrinolytic Agents/*administration & dosage, Tissue Plasminogen Activator/*administration & dosage",
author = "Yoshinari Nagakane and Soren Christensen and Caspar Brekenfeld and Henry Ma and Leonid Churilov and Parsons, {Mark W} and Levi, {Christopher R} and Butcher, {Kenneth S} and Andre Peeters and Barber, {P Alan} and Bladin, {Christopher F} and De Silva and A Deidre and John Fink and Kimber, {Thomas E} and Schultz, {David W} and Muir, {Keith W} and Tress, {Brian M} and Desmond, {Patricia M} and Davis, {Stephen M} and Donnan, {Geoffrey A} and EPITHET Investigators",
year = "2011",
language = "English",
volume = "42",
pages = "59--64",
journal = "STROKE",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - EPITHET: Positive Result After Reanalysis Using Baseline Diffusion-Weighted Imaging/Perfusion-Weighted Imaging Co-Registration.

AU - Nagakane, Yoshinari

AU - Christensen, Soren

AU - Brekenfeld, Caspar

AU - Ma, Henry

AU - Churilov, Leonid

AU - Parsons, Mark W

AU - Levi, Christopher R

AU - Butcher, Kenneth S

AU - Peeters, Andre

AU - Barber, P Alan

AU - Bladin, Christopher F

AU - Silva, De

AU - Deidre, A

AU - Fink, John

AU - Kimber, Thomas E

AU - Schultz, David W

AU - Muir, Keith W

AU - Tress, Brian M

AU - Desmond, Patricia M

AU - Davis, Stephen M

AU - Donnan, Geoffrey A

AU - Investigators, EPITHET

PY - 2011

Y1 - 2011

N2 - the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) was a prospective, randomized, double-blinded, placebo-controlled, phase II trial of alteplase between 3 and 6 hours after stroke onset. The primary outcome of infarct growth attenuation on MRI with alteplase in mismatch patients was negative when mismatch volumes were assessed volumetrically, without coregistration, which underestimates mismatch volumes. We hypothesized that assessing the extent of mismatch by coregistration of perfusion and diffusion MRI maps may more accurately allow the effects of alteplase vs placebo to be evaluated.

AB - the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) was a prospective, randomized, double-blinded, placebo-controlled, phase II trial of alteplase between 3 and 6 hours after stroke onset. The primary outcome of infarct growth attenuation on MRI with alteplase in mismatch patients was negative when mismatch volumes were assessed volumetrically, without coregistration, which underestimates mismatch volumes. We hypothesized that assessing the extent of mismatch by coregistration of perfusion and diffusion MRI maps may more accurately allow the effects of alteplase vs placebo to be evaluated.

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Time Factors

KW - Diffusion Magnetic Resonance Imaging

KW - Brain Infarction/drug therapy/metabolism/radiography

KW - Fibrinolytic Agents/administration & dosage

KW - Tissue Plasminogen Activator/administration & dosage

KW - Humans

KW - Male

KW - Aged

KW - Female

KW - Middle Aged

KW - Aged, 80 and over

KW - Time Factors

KW - Diffusion Magnetic Resonance Imaging

KW - Brain Infarction/drug therapy/metabolism/radiography

KW - Fibrinolytic Agents/administration & dosage

KW - Tissue Plasminogen Activator/administration & dosage

M3 - SCORING: Journal article

VL - 42

SP - 59

EP - 64

JO - STROKE

JF - STROKE

SN - 0039-2499

IS - 1

M1 - 1

ER -