Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry
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Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry. / Drexler, Richard; Ben-Haim, Sharona; Bien, Christian G; Borger, Valeri; Cardinale, Francesco; Carpentier, Alexandre; Cendes, Fernando; Chandra, Sarat; Clusmann, Hans; Colon, Albert; de Curtis, Marco; Delev, Daniel; Didato, Giuseppe; Dührsen, Lasse; Farah, Jibril Osman; Guenot, Marc; Ghatan, Saadi; Haegelen, Claire; Hamer, Hajo; Hauptmann, Jason S; Jeffree, Rosalind L; Kalbhenn, Thilo; Kegele, Josua; Krayenbühl, Niklaus; Lang, Johannes; Mathon, Bertrand; Naros, Georgios; Onken, Julia; Panov, Fedor; Raftopoulos, Christian; Ricklefs, Franz L; Rijkers, Kim; Rizzi, Michele; Rössler, Karl; Schijns, Olaf; Schneider, Ulf C; Spyrantis, Andrea; Strzelczyk, Adam; Stodieck, Stefan; Tripathi, Manjari; Vadera, Sumeet; Alonso-Vanegas, Mario A; Vaz, José Géraldo Ribero; Wellmer, Jörg; Wehner, Tim; Westphal, Manfred; Sauvigny, Thomas.
in: FRONT NEUROL, Jahrgang 12, 782666, 13.12.2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Enhancing Safety in Epilepsy Surgery (EASINESS): Study Protocol for a Retrospective, Multicenter, Open Registry
AU - Drexler, Richard
AU - Ben-Haim, Sharona
AU - Bien, Christian G
AU - Borger, Valeri
AU - Cardinale, Francesco
AU - Carpentier, Alexandre
AU - Cendes, Fernando
AU - Chandra, Sarat
AU - Clusmann, Hans
AU - Colon, Albert
AU - de Curtis, Marco
AU - Delev, Daniel
AU - Didato, Giuseppe
AU - Dührsen, Lasse
AU - Farah, Jibril Osman
AU - Guenot, Marc
AU - Ghatan, Saadi
AU - Haegelen, Claire
AU - Hamer, Hajo
AU - Hauptmann, Jason S
AU - Jeffree, Rosalind L
AU - Kalbhenn, Thilo
AU - Kegele, Josua
AU - Krayenbühl, Niklaus
AU - Lang, Johannes
AU - Mathon, Bertrand
AU - Naros, Georgios
AU - Onken, Julia
AU - Panov, Fedor
AU - Raftopoulos, Christian
AU - Ricklefs, Franz L
AU - Rijkers, Kim
AU - Rizzi, Michele
AU - Rössler, Karl
AU - Schijns, Olaf
AU - Schneider, Ulf C
AU - Spyrantis, Andrea
AU - Strzelczyk, Adam
AU - Stodieck, Stefan
AU - Tripathi, Manjari
AU - Vadera, Sumeet
AU - Alonso-Vanegas, Mario A
AU - Vaz, José Géraldo Ribero
AU - Wellmer, Jörg
AU - Wehner, Tim
AU - Westphal, Manfred
AU - Sauvigny, Thomas
N1 - Copyright © 2021 Drexler, Ben-Haim, Bien, Borger, Cardinale, Carpentier, Cendes, Chandra, Clusmann, Colon, Curtis, Delev, Didato, Dührsen, Farah, Guenot, Ghatan, Haegelen, Hamer, Hauptmann, Jeffree, Kalbhenn, Kegele, Krayenbühl, Lang, Mathon, Naros, Onken, Panov, Raftopoulos, Ricklefs, Rijkers, Rizzi, Rössler, Schijns, Schneider, Spyrantis, Strzelczyk, Stodieck, Tripathi, Vadera, Alonso-Vanegas, Vaz, Wellmer, Wehner, Westphal and Sauvigny.
PY - 2021/12/13
Y1 - 2021/12/13
N2 - Introduction: Optimizing patient safety and quality improvement is increasingly important in surgery. Benchmarks and clinical quality registries are being developed to assess the best achievable results for several surgical procedures and reduce unwarranted variation between different centers. However, there is no clinical database from international centers for establishing standardized reference values of patients undergoing surgery for mesial temporal lobe epilepsy. Design: The Enhancing Safety in Epilepsy Surgery (EASINESS) study is a retrospectively conducted, multicenter, open registry. All patients undergoing mesial temporal lobe epilepsy surgery in participating centers between January 2015 and December 2019 are included in this study. The patient characteristics, preoperative diagnostic tools, surgical data, postoperative complications, and long-term seizure outcomes are recorded. Outcomes: The collected data will be used for establishing standardized reference values ("benchmarks") for this type of surgical procedure. The primary endpoints include seizure outcomes according to the International League Against Epilepsy (ILAE) classification and defined postoperative complications. Discussion: The EASINESS will define robust and standardized outcome references after amygdalohippocampectomy for temporal lobe epilepsy. After the successful definition of benchmarks from an international cohort of renowned centers, these data will serve as reference values for the evaluation of novel surgical techniques and comparisons among centers for future clinical trials. Clinical trial registration: This study is indexed at clinicaltrials.gov (NT 04952298).
AB - Introduction: Optimizing patient safety and quality improvement is increasingly important in surgery. Benchmarks and clinical quality registries are being developed to assess the best achievable results for several surgical procedures and reduce unwarranted variation between different centers. However, there is no clinical database from international centers for establishing standardized reference values of patients undergoing surgery for mesial temporal lobe epilepsy. Design: The Enhancing Safety in Epilepsy Surgery (EASINESS) study is a retrospectively conducted, multicenter, open registry. All patients undergoing mesial temporal lobe epilepsy surgery in participating centers between January 2015 and December 2019 are included in this study. The patient characteristics, preoperative diagnostic tools, surgical data, postoperative complications, and long-term seizure outcomes are recorded. Outcomes: The collected data will be used for establishing standardized reference values ("benchmarks") for this type of surgical procedure. The primary endpoints include seizure outcomes according to the International League Against Epilepsy (ILAE) classification and defined postoperative complications. Discussion: The EASINESS will define robust and standardized outcome references after amygdalohippocampectomy for temporal lobe epilepsy. After the successful definition of benchmarks from an international cohort of renowned centers, these data will serve as reference values for the evaluation of novel surgical techniques and comparisons among centers for future clinical trials. Clinical trial registration: This study is indexed at clinicaltrials.gov (NT 04952298).
U2 - 10.3389/fneur.2021.782666
DO - 10.3389/fneur.2021.782666
M3 - SCORING: Journal article
C2 - 34966349
VL - 12
JO - FRONT NEUROL
JF - FRONT NEUROL
SN - 1664-2295
M1 - 782666
ER -