Enhanced activity during associative encoding in the affected hippocampus in right temporal lobe epilepsy patients.
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Enhanced activity during associative encoding in the affected hippocampus in right temporal lobe epilepsy patients. / Schwarze, Ulrike; Hahn, Christina; Bengner, Thomas; Stodieck, Stefan; Büchel, Christian; Sommer-Blöchl, Tobias.
in: BRAIN RES, Jahrgang 1297, 2009, S. 112-117.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Enhanced activity during associative encoding in the affected hippocampus in right temporal lobe epilepsy patients.
AU - Schwarze, Ulrike
AU - Hahn, Christina
AU - Bengner, Thomas
AU - Stodieck, Stefan
AU - Büchel, Christian
AU - Sommer-Blöchl, Tobias
PY - 2009
Y1 - 2009
N2 - Mnestic deficits represent the core cognitive impairment of patients with temporal lobe epilepsy (TLE), irrespective of the existence of overt morphological lesions. Compared to controls, patients with symptomatic TLE show altered functional activation patterns in fMRI studies on memory processes. But, so far, such studies have rarely investigated patients with temporal lobe epilepsy of unknown cause. Therefore, in the current study, a small sample of 6 right TLE patients with normal structural MRIs was compared to controls with respect to brain activity during encoding of face-name associations using fMRI. Compared to controls, patients retrieved fewer face-name associations correctly, but showed significantly greater activation of the affected hippocampus for successfully encoded stimuli. Therefore, higher hippocampal activation seems necessary for successful encoding of associations in patients compared to controls. But, this process is not entirely successful since the patients cannot achieve the same performance as controls. In conclusion, the hyperactivation of the hippocampus might represent a compensational but inefficient process.
AB - Mnestic deficits represent the core cognitive impairment of patients with temporal lobe epilepsy (TLE), irrespective of the existence of overt morphological lesions. Compared to controls, patients with symptomatic TLE show altered functional activation patterns in fMRI studies on memory processes. But, so far, such studies have rarely investigated patients with temporal lobe epilepsy of unknown cause. Therefore, in the current study, a small sample of 6 right TLE patients with normal structural MRIs was compared to controls with respect to brain activity during encoding of face-name associations using fMRI. Compared to controls, patients retrieved fewer face-name associations correctly, but showed significantly greater activation of the affected hippocampus for successfully encoded stimuli. Therefore, higher hippocampal activation seems necessary for successful encoding of associations in patients compared to controls. But, this process is not entirely successful since the patients cannot achieve the same performance as controls. In conclusion, the hyperactivation of the hippocampus might represent a compensational but inefficient process.
M3 - SCORING: Zeitschriftenaufsatz
VL - 1297
SP - 112
EP - 117
JO - BRAIN RES
JF - BRAIN RES
SN - 0006-8993
ER -