Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells
Beteiligte Einrichtungen
Abstract
NK cells utilize a large array of receptors to screen their surroundings for aberrant or virus-infected cells. Given the vast diversity of receptors expressed on NK cells we seek to identify receptors involved in the recognition of HIV-1-infected cells. By combining an unbiased large-scale screening approach with a functional assay, we identify TRAIL to be associated with NK cell degranulation against HIV-1-infected target cells. Further investigating the underlying mechanisms, we demonstrate that TRAIL is able to elicit multiple effector functions in human NK cells independent of receptor-mediated induction of apoptosis. Direct engagement of TRAIL not only results in degranulation but also IFNγ production. Moreover, TRAIL-mediated NK cell activation is not limited to its cognate death receptors but also decoy receptor I, adding a new perspective to the perceived regulatory role of decoy receptors in TRAIL-mediated cytotoxicity. Based on these findings, we propose that TRAIL not only contributes to the anti-HIV-1 activity of NK cells but also possesses a multifunctional role beyond receptor-mediated induction of apoptosis, acting as a regulator for the induction of different effector functions.
Bibliografische Daten
Originalsprache | Englisch |
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Aufsatznummer | e54133 |
ISSN | 1469-221X |
DOIs | |
Status | Veröffentlicht - 03.08.2022 |
Anmerkungen des Dekanats
© 2022 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
PubMed | 35758160 |
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