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Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

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Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. / Honke, Nadine; Shaabani, Namir; Cadeddu, Giuseppe; Sorg, Ursula R; Zhang, Dong-Er; Trilling, Mirko; Klingel, Karin; Sauter, Martina; Kandolf, Reinhard; Gailus, Nicole; van Rooijen, Nico; Burkart, Christoph; Baldus, Stephan E; Grusdat, Melanie; Löhning, Max; Hengel, Hartmut; Pfeffer, Klaus; Tanaka, Masato; Häussinger, Dieter; Recher, Mike; Lang, Philipp A; Lang, Karl S.

in: NAT IMMUNOL, Jahrgang 13, Nr. 1, 20.11.2011, S. 51-57.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Honke, N, Shaabani, N, Cadeddu, G, Sorg, UR, Zhang, D-E, Trilling, M, Klingel, K, Sauter, M, Kandolf, R, Gailus, N, van Rooijen, N, Burkart, C, Baldus, SE, Grusdat, M, Löhning, M, Hengel, H, Pfeffer, K, Tanaka, M, Häussinger, D, Recher, M, Lang, PA & Lang, KS 2011, 'Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus', NAT IMMUNOL, Jg. 13, Nr. 1, S. 51-57. https://doi.org/10.1038/ni.2169

APA

Honke, N., Shaabani, N., Cadeddu, G., Sorg, U. R., Zhang, D-E., Trilling, M., Klingel, K., Sauter, M., Kandolf, R., Gailus, N., van Rooijen, N., Burkart, C., Baldus, S. E., Grusdat, M., Löhning, M., Hengel, H., Pfeffer, K., Tanaka, M., Häussinger, D., ... Lang, K. S. (2011). Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. NAT IMMUNOL, 13(1), 51-57. https://doi.org/10.1038/ni.2169

Vancouver

Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang D-E, Trilling M et al. Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. NAT IMMUNOL. 2011 Nov 20;13(1):51-57. https://doi.org/10.1038/ni.2169

Bibtex

@article{b01f307e0c6d4988beb32d5bea3bfc89,
title = "Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus",
abstract = "The innate immune system limits viral replication via type I interferon and also induces the presentation of viral antigens to cells of the adaptive immune response. Using infection of mice with vesicular stomatitis virus, we analyzed how the innate immune system inhibits viral propagation but still allows the presentation of antigen to cells of the adaptive immune response. We found that expression of the gene encoding the inhibitory protein Usp18 in metallophilic macrophages led to lower type I interferon responsiveness, thereby allowing locally restricted replication of virus. This was essential for the induction of adaptive antiviral immune responses and, therefore, for preventing the fatal outcome of infection. In conclusion, we found that enforced viral replication in marginal zone macrophages was an immunological mechanism that ensured the production of sufficient antigen for effective activation of the adaptive immune response.",
keywords = "Adaptive Immunity, Animals, Antigen Presentation/immunology, Antigens, Viral/immunology, Cell Line, Transformed, Cricetinae, Dendritic Cells/immunology, Endopeptidases/metabolism, Lymphotoxin beta Receptor/metabolism, Macrophages/immunology, Membrane Glycoproteins/metabolism, Mice, Mice, 129 Strain, Mice, Inbred C57BL, Mice, Knockout, Receptors, Immunologic/metabolism, Rhabdoviridae Infections/immunology, Sialic Acid Binding Ig-like Lectin 1, Ubiquitin Thiolesterase, Vesicular stomatitis Indiana virus/immunology, Virus Replication/immunology",
author = "Nadine Honke and Namir Shaabani and Giuseppe Cadeddu and Sorg, {Ursula R} and Dong-Er Zhang and Mirko Trilling and Karin Klingel and Martina Sauter and Reinhard Kandolf and Nicole Gailus and {van Rooijen}, Nico and Christoph Burkart and Baldus, {Stephan E} and Melanie Grusdat and Max L{\"o}hning and Hartmut Hengel and Klaus Pfeffer and Masato Tanaka and Dieter H{\"a}ussinger and Mike Recher and Lang, {Philipp A} and Lang, {Karl S}",
year = "2011",
month = nov,
day = "20",
doi = "10.1038/ni.2169",
language = "English",
volume = "13",
pages = "51--57",
journal = "NAT IMMUNOL",
issn = "1529-2908",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus

AU - Honke, Nadine

AU - Shaabani, Namir

AU - Cadeddu, Giuseppe

AU - Sorg, Ursula R

AU - Zhang, Dong-Er

AU - Trilling, Mirko

AU - Klingel, Karin

AU - Sauter, Martina

AU - Kandolf, Reinhard

AU - Gailus, Nicole

AU - van Rooijen, Nico

AU - Burkart, Christoph

AU - Baldus, Stephan E

AU - Grusdat, Melanie

AU - Löhning, Max

AU - Hengel, Hartmut

AU - Pfeffer, Klaus

AU - Tanaka, Masato

AU - Häussinger, Dieter

AU - Recher, Mike

AU - Lang, Philipp A

AU - Lang, Karl S

PY - 2011/11/20

Y1 - 2011/11/20

N2 - The innate immune system limits viral replication via type I interferon and also induces the presentation of viral antigens to cells of the adaptive immune response. Using infection of mice with vesicular stomatitis virus, we analyzed how the innate immune system inhibits viral propagation but still allows the presentation of antigen to cells of the adaptive immune response. We found that expression of the gene encoding the inhibitory protein Usp18 in metallophilic macrophages led to lower type I interferon responsiveness, thereby allowing locally restricted replication of virus. This was essential for the induction of adaptive antiviral immune responses and, therefore, for preventing the fatal outcome of infection. In conclusion, we found that enforced viral replication in marginal zone macrophages was an immunological mechanism that ensured the production of sufficient antigen for effective activation of the adaptive immune response.

AB - The innate immune system limits viral replication via type I interferon and also induces the presentation of viral antigens to cells of the adaptive immune response. Using infection of mice with vesicular stomatitis virus, we analyzed how the innate immune system inhibits viral propagation but still allows the presentation of antigen to cells of the adaptive immune response. We found that expression of the gene encoding the inhibitory protein Usp18 in metallophilic macrophages led to lower type I interferon responsiveness, thereby allowing locally restricted replication of virus. This was essential for the induction of adaptive antiviral immune responses and, therefore, for preventing the fatal outcome of infection. In conclusion, we found that enforced viral replication in marginal zone macrophages was an immunological mechanism that ensured the production of sufficient antigen for effective activation of the adaptive immune response.

KW - Adaptive Immunity

KW - Animals

KW - Antigen Presentation/immunology

KW - Antigens, Viral/immunology

KW - Cell Line, Transformed

KW - Cricetinae

KW - Dendritic Cells/immunology

KW - Endopeptidases/metabolism

KW - Lymphotoxin beta Receptor/metabolism

KW - Macrophages/immunology

KW - Membrane Glycoproteins/metabolism

KW - Mice

KW - Mice, 129 Strain

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Receptors, Immunologic/metabolism

KW - Rhabdoviridae Infections/immunology

KW - Sialic Acid Binding Ig-like Lectin 1

KW - Ubiquitin Thiolesterase

KW - Vesicular stomatitis Indiana virus/immunology

KW - Virus Replication/immunology

U2 - 10.1038/ni.2169

DO - 10.1038/ni.2169

M3 - SCORING: Journal article

C2 - 22101728

VL - 13

SP - 51

EP - 57

JO - NAT IMMUNOL

JF - NAT IMMUNOL

SN - 1529-2908

IS - 1

ER -