PortalPublikationenEndogenous opioids regulate social threat learning in humans

Endogenous opioids regulate social threat learning in humans

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Endogenous opioids regulate social threat learning in humans. / Haaker, Jan; Yi, Jonathan; Petrovic, Predrag; Olsson, Andreas.

in: NAT COMMUN, Jahrgang 8, 25.05.2017, S. 15495.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Haaker, J, Yi, J, Petrovic, P & Olsson, A 2017, 'Endogenous opioids regulate social threat learning in humans', NAT COMMUN, Jg. 8, S. 15495. https://doi.org/10.1038/ncomms15495

APA

Haaker, J., Yi, J., Petrovic, P., & Olsson, A. (2017). Endogenous opioids regulate social threat learning in humans. NAT COMMUN, 8, 15495. https://doi.org/10.1038/ncomms15495

Vancouver

Haaker J, Yi J, Petrovic P, Olsson A. Endogenous opioids regulate social threat learning in humans. NAT COMMUN. 2017 Mai 25;8:15495. https://doi.org/10.1038/ncomms15495

Bibtex

@article{7481b4e9ef2544f6b8f4b84a3f795949,
title = "Endogenous opioids regulate social threat learning in humans",
abstract = "Many fearful expectations are shaped by observation of aversive outcomes to others. Yet, the neurochemistry regulating social learning is unknown. Previous research has shown that during direct (Pavlovian) threat learning, information about personally experienced outcomes is regulated by the release of endogenous opioids, and activity within the amygdala and periaqueductal gray (PAG). Here we report that blockade of this opioidergic circuit enhances social threat learning through observation in humans involving activity within the amygdala, midline thalamus and the PAG. In particular, anticipatory responses to learned threat cues (CS) were associated with temporal dynamics in the PAG, coding the observed aversive outcomes to other (observational US). In addition, pharmacological challenge of the opioid receptor function is classified by distinct brain activity patterns during the expression of conditioned threats. Our results reveal an opioidergic circuit that codes the observed aversive outcomes to others into threat responses and long-term memory in the observer.",
keywords = "Journal Article",
author = "Jan Haaker and Jonathan Yi and Predrag Petrovic and Andreas Olsson",
year = "2017",
month = may,
day = "25",
doi = "10.1038/ncomms15495",
language = "English",
volume = "8",
pages = "15495",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",

}

RIS

TY - JOUR

T1 - Endogenous opioids regulate social threat learning in humans

AU - Haaker, Jan

AU - Yi, Jonathan

AU - Petrovic, Predrag

AU - Olsson, Andreas

PY - 2017/5/25

Y1 - 2017/5/25

N2 - Many fearful expectations are shaped by observation of aversive outcomes to others. Yet, the neurochemistry regulating social learning is unknown. Previous research has shown that during direct (Pavlovian) threat learning, information about personally experienced outcomes is regulated by the release of endogenous opioids, and activity within the amygdala and periaqueductal gray (PAG). Here we report that blockade of this opioidergic circuit enhances social threat learning through observation in humans involving activity within the amygdala, midline thalamus and the PAG. In particular, anticipatory responses to learned threat cues (CS) were associated with temporal dynamics in the PAG, coding the observed aversive outcomes to other (observational US). In addition, pharmacological challenge of the opioid receptor function is classified by distinct brain activity patterns during the expression of conditioned threats. Our results reveal an opioidergic circuit that codes the observed aversive outcomes to others into threat responses and long-term memory in the observer.

AB - Many fearful expectations are shaped by observation of aversive outcomes to others. Yet, the neurochemistry regulating social learning is unknown. Previous research has shown that during direct (Pavlovian) threat learning, information about personally experienced outcomes is regulated by the release of endogenous opioids, and activity within the amygdala and periaqueductal gray (PAG). Here we report that blockade of this opioidergic circuit enhances social threat learning through observation in humans involving activity within the amygdala, midline thalamus and the PAG. In particular, anticipatory responses to learned threat cues (CS) were associated with temporal dynamics in the PAG, coding the observed aversive outcomes to other (observational US). In addition, pharmacological challenge of the opioid receptor function is classified by distinct brain activity patterns during the expression of conditioned threats. Our results reveal an opioidergic circuit that codes the observed aversive outcomes to others into threat responses and long-term memory in the observer.

KW - Journal Article

U2 - 10.1038/ncomms15495

DO - 10.1038/ncomms15495

M3 - SCORING: Journal article

C2 - 28541285

VL - 8

SP - 15495

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

ER -