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Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

Standard

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. / Schlein, Christian; Fischer, Alexander W; Sass, Frederike; Worthmann, Anna; Tödter, Klaus; Jaeckstein, Michelle Y; Behrens, Janina; Lynes, Matthew D; Kiebish, Michael A; Narain, Niven R; Bussberg, Val; Jespersen, Naja Zenius; Nielsen, Søren; Scheele, Camilla; Schweizer, Michaela; Braren, Ingke; Bartelt, Alexander; Tseng, Yu-Hua; Heeren, Joerg; Scheja, Ludger.

in: CELL REP, Jahrgang 34, Nr. 2, 12.01.2021, S. 108624.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schlein, C, Fischer, AW, Sass, F, Worthmann, A, Tödter, K, Jaeckstein, MY, Behrens, J, Lynes, MD, Kiebish, MA, Narain, NR, Bussberg, V, Jespersen, NZ, Nielsen, S, Scheele, C, Schweizer, M, Braren, I, Bartelt, A, Tseng, Y-H, Heeren, J & Scheja, L 2021, 'Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution', CELL REP, Jg. 34, Nr. 2, S. 108624. https://doi.org/10.1016/j.celrep.2020.108624

APA

Schlein, C., Fischer, A. W., Sass, F., Worthmann, A., Tödter, K., Jaeckstein, M. Y., Behrens, J., Lynes, M. D., Kiebish, M. A., Narain, N. R., Bussberg, V., Jespersen, N. Z., Nielsen, S., Scheele, C., Schweizer, M., Braren, I., Bartelt, A., Tseng, Y-H., Heeren, J., & Scheja, L. (2021). Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. CELL REP, 34(2), 108624. https://doi.org/10.1016/j.celrep.2020.108624

Vancouver

Schlein C, Fischer AW, Sass F, Worthmann A, Tödter K, Jaeckstein MY et al. Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. CELL REP. 2021 Jan 12;34(2):108624. https://doi.org/10.1016/j.celrep.2020.108624

Bibtex

@article{2985bb6b68274a3392d075db35457d7f,
title = "Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution",
abstract = "Thermoneutral conditions typical for standard human living environments result in brown adipose tissue (BAT) involution, characterized by decreased mitochondrial mass and increased lipid deposition. Low BAT activity is associated with poor metabolic health, and BAT reactivation may confer therapeutic potential. However, the molecular drivers of this BAT adaptive process in response to thermoneutrality remain enigmatic. Using metabolic and lipidomic approaches, we show that endogenous fatty acid synthesis, regulated by carbohydrate-response element-binding protein (ChREBP), is the central regulator of BAT involution. By transcriptional control of lipogenesis-related enzymes, ChREBP determines the abundance and composition of both storage and membrane lipids known to regulate organelle turnover and function. Notably, ChREBP deficiency and pharmacological inhibition of lipogenesis during thermoneutral adaptation preserved mitochondrial mass and thermogenic capacity of BAT independently of mitochondrial biogenesis. In conclusion, we establish lipogenesis as a potential therapeutic target to prevent loss of BAT thermogenic capacity as seen in adult humans.",
author = "Christian Schlein and Fischer, {Alexander W} and Frederike Sass and Anna Worthmann and Klaus T{\"o}dter and Jaeckstein, {Michelle Y} and Janina Behrens and Lynes, {Matthew D} and Kiebish, {Michael A} and Narain, {Niven R} and Val Bussberg and Jespersen, {Naja Zenius} and S{\o}ren Nielsen and Camilla Scheele and Michaela Schweizer and Ingke Braren and Alexander Bartelt and Yu-Hua Tseng and Joerg Heeren and Ludger Scheja",
note = "Copyright {\textcopyright} 2020 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2021",
month = jan,
day = "12",
doi = "10.1016/j.celrep.2020.108624",
language = "English",
volume = "34",
pages = "108624",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution

AU - Schlein, Christian

AU - Fischer, Alexander W

AU - Sass, Frederike

AU - Worthmann, Anna

AU - Tödter, Klaus

AU - Jaeckstein, Michelle Y

AU - Behrens, Janina

AU - Lynes, Matthew D

AU - Kiebish, Michael A

AU - Narain, Niven R

AU - Bussberg, Val

AU - Jespersen, Naja Zenius

AU - Nielsen, Søren

AU - Scheele, Camilla

AU - Schweizer, Michaela

AU - Braren, Ingke

AU - Bartelt, Alexander

AU - Tseng, Yu-Hua

AU - Heeren, Joerg

AU - Scheja, Ludger

N1 - Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2021/1/12

Y1 - 2021/1/12

N2 - Thermoneutral conditions typical for standard human living environments result in brown adipose tissue (BAT) involution, characterized by decreased mitochondrial mass and increased lipid deposition. Low BAT activity is associated with poor metabolic health, and BAT reactivation may confer therapeutic potential. However, the molecular drivers of this BAT adaptive process in response to thermoneutrality remain enigmatic. Using metabolic and lipidomic approaches, we show that endogenous fatty acid synthesis, regulated by carbohydrate-response element-binding protein (ChREBP), is the central regulator of BAT involution. By transcriptional control of lipogenesis-related enzymes, ChREBP determines the abundance and composition of both storage and membrane lipids known to regulate organelle turnover and function. Notably, ChREBP deficiency and pharmacological inhibition of lipogenesis during thermoneutral adaptation preserved mitochondrial mass and thermogenic capacity of BAT independently of mitochondrial biogenesis. In conclusion, we establish lipogenesis as a potential therapeutic target to prevent loss of BAT thermogenic capacity as seen in adult humans.

AB - Thermoneutral conditions typical for standard human living environments result in brown adipose tissue (BAT) involution, characterized by decreased mitochondrial mass and increased lipid deposition. Low BAT activity is associated with poor metabolic health, and BAT reactivation may confer therapeutic potential. However, the molecular drivers of this BAT adaptive process in response to thermoneutrality remain enigmatic. Using metabolic and lipidomic approaches, we show that endogenous fatty acid synthesis, regulated by carbohydrate-response element-binding protein (ChREBP), is the central regulator of BAT involution. By transcriptional control of lipogenesis-related enzymes, ChREBP determines the abundance and composition of both storage and membrane lipids known to regulate organelle turnover and function. Notably, ChREBP deficiency and pharmacological inhibition of lipogenesis during thermoneutral adaptation preserved mitochondrial mass and thermogenic capacity of BAT independently of mitochondrial biogenesis. In conclusion, we establish lipogenesis as a potential therapeutic target to prevent loss of BAT thermogenic capacity as seen in adult humans.

U2 - 10.1016/j.celrep.2020.108624

DO - 10.1016/j.celrep.2020.108624

M3 - SCORING: Journal article

C2 - 33440156

VL - 34

SP - 108624

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 2

ER -