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Endogenous coenzyme A glutathione disulfide in human myocardial tissue

Standard

Endogenous coenzyme A glutathione disulfide in human myocardial tissue. / Luo, J; Jankowski, V; Henning, L; Schlüter, H; Zidek, W; Jankowski, J.

in: J ENDOCRINOL INVEST, Jahrgang 29, Nr. 8, 09.2006, S. 688-93.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Luo, J, Jankowski, V, Henning, L, Schlüter, H, Zidek, W & Jankowski, J 2006, 'Endogenous coenzyme A glutathione disulfide in human myocardial tissue', J ENDOCRINOL INVEST, Jg. 29, Nr. 8, S. 688-93. https://doi.org/10.1007/BF03344177

APA

Luo, J., Jankowski, V., Henning, L., Schlüter, H., Zidek, W., & Jankowski, J. (2006). Endogenous coenzyme A glutathione disulfide in human myocardial tissue. J ENDOCRINOL INVEST, 29(8), 688-93. https://doi.org/10.1007/BF03344177

Vancouver

Luo J, Jankowski V, Henning L, Schlüter H, Zidek W, Jankowski J. Endogenous coenzyme A glutathione disulfide in human myocardial tissue. J ENDOCRINOL INVEST. 2006 Sep;29(8):688-93. https://doi.org/10.1007/BF03344177

Bibtex

@article{07648b7e6a1e44a9b8f46a66f8544d21,
title = "Endogenous coenzyme A glutathione disulfide in human myocardial tissue",
abstract = "Besides its role as a mechanical pump, the human heart serves as an endocrine organ, where known and as yet unknown hormones are produced. It is very likely that these hormones play an important role in cardiovascular regulation. In this study, a new endogenous vasoactive substance, coenzyme A glutathione disulfide (CoASSG), was isolated and identified in myocardial tissue. Human myocardial tissue was extracted with perchloric acid and fractionated by size exclusion-, displacement-, anion-exchange- and reversed-phase chromatography. In one fraction purified to homogeneity, CoASSG was identified by matrix assisted laser desorption/ionization (MALDI) mass-spectrometry, post-source decay MALDI-mass spectrometry and enzymatic structure analysis. Furthermore, CoASSG was also isolated from human cardiac specific granules. CoASSG has potent vasoconstrictive and proliferative effects. Therefore, CoASSG may affect myocardial function as an endocrine or autocrine substance after being released from myocardial specific granules.",
keywords = "Coenzyme A, Female, Glutathione Disulfide, Humans, Male, Middle Aged, Myocardium, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Journal Article",
author = "J Luo and V Jankowski and L Henning and H Schl{\"u}ter and W Zidek and J Jankowski",
year = "2006",
month = sep,
doi = "10.1007/BF03344177",
language = "English",
volume = "29",
pages = "688--93",
journal = "J ENDOCRINOL INVEST",
issn = "0391-4097",
publisher = "Editrice Kurtis s.r.l.",
number = "8",

}

RIS

TY - JOUR

T1 - Endogenous coenzyme A glutathione disulfide in human myocardial tissue

AU - Luo, J

AU - Jankowski, V

AU - Henning, L

AU - Schlüter, H

AU - Zidek, W

AU - Jankowski, J

PY - 2006/9

Y1 - 2006/9

N2 - Besides its role as a mechanical pump, the human heart serves as an endocrine organ, where known and as yet unknown hormones are produced. It is very likely that these hormones play an important role in cardiovascular regulation. In this study, a new endogenous vasoactive substance, coenzyme A glutathione disulfide (CoASSG), was isolated and identified in myocardial tissue. Human myocardial tissue was extracted with perchloric acid and fractionated by size exclusion-, displacement-, anion-exchange- and reversed-phase chromatography. In one fraction purified to homogeneity, CoASSG was identified by matrix assisted laser desorption/ionization (MALDI) mass-spectrometry, post-source decay MALDI-mass spectrometry and enzymatic structure analysis. Furthermore, CoASSG was also isolated from human cardiac specific granules. CoASSG has potent vasoconstrictive and proliferative effects. Therefore, CoASSG may affect myocardial function as an endocrine or autocrine substance after being released from myocardial specific granules.

AB - Besides its role as a mechanical pump, the human heart serves as an endocrine organ, where known and as yet unknown hormones are produced. It is very likely that these hormones play an important role in cardiovascular regulation. In this study, a new endogenous vasoactive substance, coenzyme A glutathione disulfide (CoASSG), was isolated and identified in myocardial tissue. Human myocardial tissue was extracted with perchloric acid and fractionated by size exclusion-, displacement-, anion-exchange- and reversed-phase chromatography. In one fraction purified to homogeneity, CoASSG was identified by matrix assisted laser desorption/ionization (MALDI) mass-spectrometry, post-source decay MALDI-mass spectrometry and enzymatic structure analysis. Furthermore, CoASSG was also isolated from human cardiac specific granules. CoASSG has potent vasoconstrictive and proliferative effects. Therefore, CoASSG may affect myocardial function as an endocrine or autocrine substance after being released from myocardial specific granules.

KW - Coenzyme A

KW - Female

KW - Glutathione Disulfide

KW - Humans

KW - Male

KW - Middle Aged

KW - Myocardium

KW - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

KW - Journal Article

U2 - 10.1007/BF03344177

DO - 10.1007/BF03344177

M3 - SCORING: Journal article

C2 - 17033256

VL - 29

SP - 688

EP - 693

JO - J ENDOCRINOL INVEST

JF - J ENDOCRINOL INVEST

SN - 0391-4097

IS - 8

ER -