Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study.

Heiko Pohl; Thomas Rösch; Barbara T Tanczos; Birgit Rudolph; Karsten Schlüns; Daniel C Baumgart

doi:10.1016/j.gie.2009.04.043

Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study.

Standard

Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study. / Pohl, Heiko; Rösch, Thomas; Tanczos, Barbara T; Rudolph, Birgit; Schlüns, Karsten; Baumgart, Daniel C.

in: GASTROINTEST ENDOSC, Jahrgang 70, Nr. 5, 5, 01.11.2009, S. 933-941.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Pohl, H, Rösch, T, Tanczos, BT, Rudolph, B, Schlüns, K & Baumgart, DC 2009, 'Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study.', GASTROINTEST ENDOSC, Jg. 70, Nr. 5, 5, S. 933-941. https://doi.org/10.1016/j.gie.2009.04.043

APA

Pohl, H., Rösch, T., Tanczos, B. T., Rudolph, B., Schlüns, K., & Baumgart, D. C. (2009). Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study. GASTROINTEST ENDOSC, 70(5), 933-941. [5]. https://doi.org/10.1016/j.gie.2009.04.043

Vancouver

Pohl H, Rösch T, Tanczos BT, Rudolph B, Schlüns K, Baumgart DC. Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study. GASTROINTEST ENDOSC. 2009 Nov 1;70(5):933-941. 5. https://doi.org/10.1016/j.gie.2009.04.043

Bibtex

@article{56c44ed6a65a4f9bb73a01f7feaad446,

title = "Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study.",

abstract = "BACKGROUND: Endocytoscopy (EC) is a novel technique that allows magnified live inspection of the intestinal mucosa. OBJECTIVE: To evaluate EC for the detection of key pathological findings in patients with celiac sprue. DESIGN: A total of 166 EC recordings were prospectively acquired. Matched videos, images, and biopsy specimens were obtained by duodenal argon beamer labeling of the respective sites. SETTING: Academic tertiary referral center. PATIENTS: Forty patients (mean age 51.5 years, 70% women) with established (n = 32) or suspected (n = 8) celiac disease (CD). INTERVENTIONS: A validated scoring system (Marsh classification) was used to assess disease activity. EC criteria were independently evaluated by 2 gastroenterologists and 1 pathologist. MAIN OUTCOME MEASUREMENTS: The primary endpoint was to examine EC correlation with conventional CD histology. RESULTS: Of 166 duodenal biopsy sites, 23% were classified as Marsh III (moderate to severe), 10% as Marsh I (mild), and 67% as Marsh 0 (normal). Using the 450x magnification, we found that identification of crypts was diagnostic for celiac pathology. Four criteria were significant predictors of Marsh III pathology when adjusted by multivariate analysis: low number of villi per visual field (",

keywords = "Biopsy, Diagnosis, Differential, Humans, Male, Female, Middle Aged, Prospective Studies, Reproducibility of Results, Endoscopy, Gastrointestinal methods, Celiac Disease diagnosis, Duodenum pathology, Intestinal Mucosa pathology, Biopsy, Diagnosis, Differential, Humans, Male, Female, Middle Aged, Prospective Studies, Reproducibility of Results, Endoscopy, Gastrointestinal methods, Celiac Disease diagnosis, Duodenum pathology, Intestinal Mucosa pathology",

author = "Heiko Pohl and Thomas R{\"o}sch and Tanczos, {Barbara T} and Birgit Rudolph and Karsten Schl{\"u}ns and Baumgart, {Daniel C}",

year = "2009",

month = nov,

day = "1",

doi = "10.1016/j.gie.2009.04.043",

language = "English",

volume = "70",

pages = "933--941",

journal = "GASTROINTEST ENDOSC",

issn = "0016-5107",

publisher = "Mosby Inc.",

number = "5",

}

RIS

TY - JOUR

T1 - Endocytoscopy for the detection of microstructural features in adult patients with celiac sprue: a prospective, blinded endocytoscopy-conventional histology correlation study.

AU - Pohl, Heiko

AU - Rösch, Thomas

AU - Tanczos, Barbara T

AU - Rudolph, Birgit

AU - Schlüns, Karsten

AU - Baumgart, Daniel C

PY - 2009/11/1

Y1 - 2009/11/1

N2 - BACKGROUND: Endocytoscopy (EC) is a novel technique that allows magnified live inspection of the intestinal mucosa. OBJECTIVE: To evaluate EC for the detection of key pathological findings in patients with celiac sprue. DESIGN: A total of 166 EC recordings were prospectively acquired. Matched videos, images, and biopsy specimens were obtained by duodenal argon beamer labeling of the respective sites. SETTING: Academic tertiary referral center. PATIENTS: Forty patients (mean age 51.5 years, 70% women) with established (n = 32) or suspected (n = 8) celiac disease (CD). INTERVENTIONS: A validated scoring system (Marsh classification) was used to assess disease activity. EC criteria were independently evaluated by 2 gastroenterologists and 1 pathologist. MAIN OUTCOME MEASUREMENTS: The primary endpoint was to examine EC correlation with conventional CD histology. RESULTS: Of 166 duodenal biopsy sites, 23% were classified as Marsh III (moderate to severe), 10% as Marsh I (mild), and 67% as Marsh 0 (normal). Using the 450x magnification, we found that identification of crypts was diagnostic for celiac pathology. Four criteria were significant predictors of Marsh III pathology when adjusted by multivariate analysis: low number of villi per visual field (

AB - BACKGROUND: Endocytoscopy (EC) is a novel technique that allows magnified live inspection of the intestinal mucosa. OBJECTIVE: To evaluate EC for the detection of key pathological findings in patients with celiac sprue. DESIGN: A total of 166 EC recordings were prospectively acquired. Matched videos, images, and biopsy specimens were obtained by duodenal argon beamer labeling of the respective sites. SETTING: Academic tertiary referral center. PATIENTS: Forty patients (mean age 51.5 years, 70% women) with established (n = 32) or suspected (n = 8) celiac disease (CD). INTERVENTIONS: A validated scoring system (Marsh classification) was used to assess disease activity. EC criteria were independently evaluated by 2 gastroenterologists and 1 pathologist. MAIN OUTCOME MEASUREMENTS: The primary endpoint was to examine EC correlation with conventional CD histology. RESULTS: Of 166 duodenal biopsy sites, 23% were classified as Marsh III (moderate to severe), 10% as Marsh I (mild), and 67% as Marsh 0 (normal). Using the 450x magnification, we found that identification of crypts was diagnostic for celiac pathology. Four criteria were significant predictors of Marsh III pathology when adjusted by multivariate analysis: low number of villi per visual field (

KW - Biopsy

KW - Diagnosis, Differential

KW - Humans

KW - Male

KW - Female

KW - Middle Aged

KW - Prospective Studies

KW - Reproducibility of Results

KW - Endoscopy, Gastrointestinal methods

KW - Celiac Disease diagnosis

KW - Duodenum pathology

KW - Intestinal Mucosa pathology

KW - Biopsy

KW - Diagnosis, Differential

KW - Humans

KW - Male

KW - Female

KW - Middle Aged

KW - Prospective Studies

KW - Reproducibility of Results

KW - Endoscopy, Gastrointestinal methods

KW - Celiac Disease diagnosis

KW - Duodenum pathology

KW - Intestinal Mucosa pathology

U2 - 10.1016/j.gie.2009.04.043

DO - 10.1016/j.gie.2009.04.043

M3 - SCORING: Journal article

C2 - 19560762

VL - 70

SP - 933

EP - 941

JO - GASTROINTEST ENDOSC

JF - GASTROINTEST ENDOSC

SN - 0016-5107

IS - 5

M1 - 5

ER -