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Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients.

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Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients. / Puchhammer-Stöckl, Elisabeth; Görzer, Irene; Zoufaly, Alexander; Jaksch, Peter; Bauer, Claudia C; Klepetko, Walter; Popow-Kraupp, Therese.

in: TRANSPLANTATION, Jahrgang 81, Nr. 2, 2, 2006, S. 187-194.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Puchhammer-Stöckl, E, Görzer, I, Zoufaly, A, Jaksch, P, Bauer, CC, Klepetko, W & Popow-Kraupp, T 2006, 'Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients.', TRANSPLANTATION, Jg. 81, Nr. 2, 2, S. 187-194. <http://www.ncbi.nlm.nih.gov/pubmed/16436961?dopt=Citation>

APA

Puchhammer-Stöckl, E., Görzer, I., Zoufaly, A., Jaksch, P., Bauer, C. C., Klepetko, W., & Popow-Kraupp, T. (2006). Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients. TRANSPLANTATION, 81(2), 187-194. [2]. http://www.ncbi.nlm.nih.gov/pubmed/16436961?dopt=Citation

Vancouver

Puchhammer-Stöckl E, Görzer I, Zoufaly A, Jaksch P, Bauer CC, Klepetko W et al. Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients. TRANSPLANTATION. 2006;81(2):187-194. 2.

Bibtex

@article{768c6ac6dd3b49e3b42bc4749a603a44,
title = "Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients.",
abstract = "BACKGROUND: Cytomegalovirus (CMV) is a major pathogen in lung transplant recipients (LTRs). The emergence of different CMV strains in lung and blood after transplantation has not yet been analyzed. METHODS: In total, 75 serum and 91 broncheoalveolar lavage (BAL) samples obtained from 25 LTRs in the follow-up after transplantation were tested for the presence of different CMV strains. The gB, gN, and gO genes of the CMV isolates were analyzed by subtype-specific PCR, restriction fragment length polymorphism (RFLP), sequencing, and phylogenetic analysis. RESULTS: Mixed CMV-strain populations were detected after cessation of antiviral prophylaxis in up to 80% and 90% of the patients' BAL and serum, respectively, and this was independent of the CMV serostatus of donor and recipient. In five patients, the same single CMV strain was consistently detectable over at least 1 year in lung and blood, although in two of these cases donor and recipient had both been CMV-seropositive. Most CMV strains were distributed in the lung and blood compartment. Symptomatic CMV infection within the first year after transplantation was observed only in patients with mixed CMV-strain populations (P",
author = "Elisabeth Puchhammer-St{\"o}ckl and Irene G{\"o}rzer and Alexander Zoufaly and Peter Jaksch and Bauer, {Claudia C} and Walter Klepetko and Therese Popow-Kraupp",
year = "2006",
language = "Deutsch",
volume = "81",
pages = "187--194",
journal = "TRANSPLANTATION",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Emergence of multiple cytomegalovirus strains in blood and lung of lung transplant recipients.

AU - Puchhammer-Stöckl, Elisabeth

AU - Görzer, Irene

AU - Zoufaly, Alexander

AU - Jaksch, Peter

AU - Bauer, Claudia C

AU - Klepetko, Walter

AU - Popow-Kraupp, Therese

PY - 2006

Y1 - 2006

N2 - BACKGROUND: Cytomegalovirus (CMV) is a major pathogen in lung transplant recipients (LTRs). The emergence of different CMV strains in lung and blood after transplantation has not yet been analyzed. METHODS: In total, 75 serum and 91 broncheoalveolar lavage (BAL) samples obtained from 25 LTRs in the follow-up after transplantation were tested for the presence of different CMV strains. The gB, gN, and gO genes of the CMV isolates were analyzed by subtype-specific PCR, restriction fragment length polymorphism (RFLP), sequencing, and phylogenetic analysis. RESULTS: Mixed CMV-strain populations were detected after cessation of antiviral prophylaxis in up to 80% and 90% of the patients' BAL and serum, respectively, and this was independent of the CMV serostatus of donor and recipient. In five patients, the same single CMV strain was consistently detectable over at least 1 year in lung and blood, although in two of these cases donor and recipient had both been CMV-seropositive. Most CMV strains were distributed in the lung and blood compartment. Symptomatic CMV infection within the first year after transplantation was observed only in patients with mixed CMV-strain populations (P

AB - BACKGROUND: Cytomegalovirus (CMV) is a major pathogen in lung transplant recipients (LTRs). The emergence of different CMV strains in lung and blood after transplantation has not yet been analyzed. METHODS: In total, 75 serum and 91 broncheoalveolar lavage (BAL) samples obtained from 25 LTRs in the follow-up after transplantation were tested for the presence of different CMV strains. The gB, gN, and gO genes of the CMV isolates were analyzed by subtype-specific PCR, restriction fragment length polymorphism (RFLP), sequencing, and phylogenetic analysis. RESULTS: Mixed CMV-strain populations were detected after cessation of antiviral prophylaxis in up to 80% and 90% of the patients' BAL and serum, respectively, and this was independent of the CMV serostatus of donor and recipient. In five patients, the same single CMV strain was consistently detectable over at least 1 year in lung and blood, although in two of these cases donor and recipient had both been CMV-seropositive. Most CMV strains were distributed in the lung and blood compartment. Symptomatic CMV infection within the first year after transplantation was observed only in patients with mixed CMV-strain populations (P

M3 - SCORING: Zeitschriftenaufsatz

VL - 81

SP - 187

EP - 194

JO - TRANSPLANTATION

JF - TRANSPLANTATION

SN - 0041-1337

IS - 2

M1 - 2

ER -