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Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.

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Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. / Park, Sungjin; Park, Joo Min; Kim, Sangmok; Kim, Jin-Ah; Shepherd, Jason D; Smith-Hicks, Constance L; Chowdhury, Shoaib; Kaufmann, Walter; Kuhl, Dietmar; Ryazanov, Alexey G; Huganir, Richard L; Linden, David J; Worley, Paul F.

in: NEURON, Jahrgang 59, Nr. 1, 1, 2008, S. 70-83.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Park, S, Park, JM, Kim, S, Kim, J-A, Shepherd, JD, Smith-Hicks, CL, Chowdhury, S, Kaufmann, W, Kuhl, D, Ryazanov, AG, Huganir, RL, Linden, DJ & Worley, PF 2008, 'Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.', NEURON, Jg. 59, Nr. 1, 1, S. 70-83. <http://www.ncbi.nlm.nih.gov/pubmed/18614030?dopt=Citation>

APA

Park, S., Park, J. M., Kim, S., Kim, J-A., Shepherd, J. D., Smith-Hicks, C. L., Chowdhury, S., Kaufmann, W., Kuhl, D., Ryazanov, A. G., Huganir, R. L., Linden, D. J., & Worley, P. F. (2008). Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. NEURON, 59(1), 70-83. [1]. http://www.ncbi.nlm.nih.gov/pubmed/18614030?dopt=Citation

Vancouver

Park S, Park JM, Kim S, Kim J-A, Shepherd JD, Smith-Hicks CL et al. Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD. NEURON. 2008;59(1):70-83. 1.

Bibtex

@article{2d65e0cb54b74a158de8b25ff15c6ea9,
title = "Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.",
abstract = "Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires eEF2K, a Ca(2+)/calmodulin-dependent kinase that binds mGluR and dissociates upon mGluR activation, whereupon it phosphorylates eEF2. Phospho-eEF2 acts to slow the elongation step of translation and inhibits general protein synthesis but simultaneously increases Arc/Arg3.1 translation. Genetic deletion of eEF2K results in a selective deficit of rapid mGluR-dependent Arc/Arg3.1 translation and mGluR-LTD. This rapid translational mechanism is disrupted in the fragile X disease mouse (Fmr1 KO) in which mGluR-LTD does not require de novo protein synthesis but does require Arc/Arg3.1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD.",
author = "Sungjin Park and Park, {Joo Min} and Sangmok Kim and Jin-Ah Kim and Shepherd, {Jason D} and Smith-Hicks, {Constance L} and Shoaib Chowdhury and Walter Kaufmann and Dietmar Kuhl and Ryazanov, {Alexey G} and Huganir, {Richard L} and Linden, {David J} and Worley, {Paul F}",
year = "2008",
language = "Deutsch",
volume = "59",
pages = "70--83",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD.

AU - Park, Sungjin

AU - Park, Joo Min

AU - Kim, Sangmok

AU - Kim, Jin-Ah

AU - Shepherd, Jason D

AU - Smith-Hicks, Constance L

AU - Chowdhury, Shoaib

AU - Kaufmann, Walter

AU - Kuhl, Dietmar

AU - Ryazanov, Alexey G

AU - Huganir, Richard L

AU - Linden, David J

AU - Worley, Paul F

PY - 2008

Y1 - 2008

N2 - Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires eEF2K, a Ca(2+)/calmodulin-dependent kinase that binds mGluR and dissociates upon mGluR activation, whereupon it phosphorylates eEF2. Phospho-eEF2 acts to slow the elongation step of translation and inhibits general protein synthesis but simultaneously increases Arc/Arg3.1 translation. Genetic deletion of eEF2K results in a selective deficit of rapid mGluR-dependent Arc/Arg3.1 translation and mGluR-LTD. This rapid translational mechanism is disrupted in the fragile X disease mouse (Fmr1 KO) in which mGluR-LTD does not require de novo protein synthesis but does require Arc/Arg3.1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD.

AB - Group I metabotropic glutamate receptors (mGluR) induce long-term depression (LTD) that requires protein synthesis. Here, we demonstrate that Arc/Arg3.1 is translationally induced within 5 min of mGluR activation, and this response is essential for mGluR-dependent LTD. The increase in Arc/Arg3.1 translation requires eEF2K, a Ca(2+)/calmodulin-dependent kinase that binds mGluR and dissociates upon mGluR activation, whereupon it phosphorylates eEF2. Phospho-eEF2 acts to slow the elongation step of translation and inhibits general protein synthesis but simultaneously increases Arc/Arg3.1 translation. Genetic deletion of eEF2K results in a selective deficit of rapid mGluR-dependent Arc/Arg3.1 translation and mGluR-LTD. This rapid translational mechanism is disrupted in the fragile X disease mouse (Fmr1 KO) in which mGluR-LTD does not require de novo protein synthesis but does require Arc/Arg3.1. We propose a model in which eEF2K-eEF2 and FMRP coordinately control the dynamic translation of Arc/Arg3.1 mRNA in dendrites that is critical for synapse-specific LTD.

M3 - SCORING: Zeitschriftenaufsatz

VL - 59

SP - 70

EP - 83

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 1

M1 - 1

ER -