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Elimination of beta-hexachlorocyclohexane in occupationally exposed persons.

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Elimination of beta-hexachlorocyclohexane in occupationally exposed persons. / Jung, D; Becher, H; Edler, L; Flesch-Janys, Dieter; Gurn, P; Konietzko, J; Manz, A; Päpke, O.

in: J TOXICOL ENV HEALTH, Jahrgang 51, Nr. 1, 1, 1997, S. 23-34.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jung, D, Becher, H, Edler, L, Flesch-Janys, D, Gurn, P, Konietzko, J, Manz, A & Päpke, O 1997, 'Elimination of beta-hexachlorocyclohexane in occupationally exposed persons.', J TOXICOL ENV HEALTH, Jg. 51, Nr. 1, 1, S. 23-34. <http://www.ncbi.nlm.nih.gov/pubmed/9169059?dopt=Citation>

APA

Jung, D., Becher, H., Edler, L., Flesch-Janys, D., Gurn, P., Konietzko, J., Manz, A., & Päpke, O. (1997). Elimination of beta-hexachlorocyclohexane in occupationally exposed persons. J TOXICOL ENV HEALTH, 51(1), 23-34. [1]. http://www.ncbi.nlm.nih.gov/pubmed/9169059?dopt=Citation

Vancouver

Jung D, Becher H, Edler L, Flesch-Janys D, Gurn P, Konietzko J et al. Elimination of beta-hexachlorocyclohexane in occupationally exposed persons. J TOXICOL ENV HEALTH. 1997;51(1):23-34. 1.

Bibtex

@article{97a926054642473091fdd2dc16a6a37d,
title = "Elimination of beta-hexachlorocyclohexane in occupationally exposed persons.",
abstract = "The elimination of beta-hexachlorocyclohexane (beta-HCH) in humans was investigated in a group of 40 former workers of a lindane-producing plant by analyzing at least 2 blood specimens (3 specimens in 3 workers) from different time points. Assuming a first-order kinetic model for excretion, the median half-life of beta-HCH is 7.2 yr calculated by concentrations in whole blood and 7.6 yr calculated by concentrations in extractable lipids. In univariate analyses an influence of age, percent body fat, and liver disease (additionally in whole blood an influence of contents of extractable lipids) on clearance was observed. All factors show a positive correlation with half-life. According to a multiple regression model, influence of percent body fat calculated according to Deurenberg et al. (1991) is an important covariate in the description of the variations of the clearance rate (calculated on the basis of extractable lipids) of beta-HCH. The data support the assumption of first-order kinetics.",
author = "D Jung and H Becher and L Edler and Dieter Flesch-Janys and P Gurn and J Konietzko and A Manz and O P{\"a}pke",
year = "1997",
language = "Deutsch",
volume = "51",
pages = "23--34",
number = "1",

}

RIS

TY - JOUR

T1 - Elimination of beta-hexachlorocyclohexane in occupationally exposed persons.

AU - Jung, D

AU - Becher, H

AU - Edler, L

AU - Flesch-Janys, Dieter

AU - Gurn, P

AU - Konietzko, J

AU - Manz, A

AU - Päpke, O

PY - 1997

Y1 - 1997

N2 - The elimination of beta-hexachlorocyclohexane (beta-HCH) in humans was investigated in a group of 40 former workers of a lindane-producing plant by analyzing at least 2 blood specimens (3 specimens in 3 workers) from different time points. Assuming a first-order kinetic model for excretion, the median half-life of beta-HCH is 7.2 yr calculated by concentrations in whole blood and 7.6 yr calculated by concentrations in extractable lipids. In univariate analyses an influence of age, percent body fat, and liver disease (additionally in whole blood an influence of contents of extractable lipids) on clearance was observed. All factors show a positive correlation with half-life. According to a multiple regression model, influence of percent body fat calculated according to Deurenberg et al. (1991) is an important covariate in the description of the variations of the clearance rate (calculated on the basis of extractable lipids) of beta-HCH. The data support the assumption of first-order kinetics.

AB - The elimination of beta-hexachlorocyclohexane (beta-HCH) in humans was investigated in a group of 40 former workers of a lindane-producing plant by analyzing at least 2 blood specimens (3 specimens in 3 workers) from different time points. Assuming a first-order kinetic model for excretion, the median half-life of beta-HCH is 7.2 yr calculated by concentrations in whole blood and 7.6 yr calculated by concentrations in extractable lipids. In univariate analyses an influence of age, percent body fat, and liver disease (additionally in whole blood an influence of contents of extractable lipids) on clearance was observed. All factors show a positive correlation with half-life. According to a multiple regression model, influence of percent body fat calculated according to Deurenberg et al. (1991) is an important covariate in the description of the variations of the clearance rate (calculated on the basis of extractable lipids) of beta-HCH. The data support the assumption of first-order kinetics.

M3 - SCORING: Zeitschriftenaufsatz

VL - 51

SP - 23

EP - 34

IS - 1

M1 - 1

ER -