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Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation

Standard

Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation. / Haen, Sebastian P; Gouttefangeas, Cécile; Schmidt, Diethard; Boss, Andreas; Clasen, Stephan; von Herbay, Alexandra; Kosan, Bora; Aebert, Hermann; Pereira, Philippe L; Rammensee, Hans-Georg.

in: CELL STRESS CHAPERON, Jahrgang 16, Nr. 5, 09.2011, S. 495-504.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Haen, SP, Gouttefangeas, C, Schmidt, D, Boss, A, Clasen, S, von Herbay, A, Kosan, B, Aebert, H, Pereira, PL & Rammensee, H-G 2011, 'Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation', CELL STRESS CHAPERON, Jg. 16, Nr. 5, S. 495-504. https://doi.org/10.1007/s12192-011-0261-y

APA

Haen, S. P., Gouttefangeas, C., Schmidt, D., Boss, A., Clasen, S., von Herbay, A., Kosan, B., Aebert, H., Pereira, P. L., & Rammensee, H-G. (2011). Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation. CELL STRESS CHAPERON, 16(5), 495-504. https://doi.org/10.1007/s12192-011-0261-y

Vancouver

Haen SP, Gouttefangeas C, Schmidt D, Boss A, Clasen S, von Herbay A et al. Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation. CELL STRESS CHAPERON. 2011 Sep;16(5):495-504. https://doi.org/10.1007/s12192-011-0261-y

Bibtex

@article{74c78493df3e4c83966d88fd016b21c0,
title = "Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation",
abstract = "Due to their adjuvant effect and their ability to chaperone tumor-associated peptides, heat shock proteins constitute a potent alarm signal for the immune system and can lead to activation of anti-tumor T-cell immunity. Radiofrequency ablation has been reported to induce heat shock protein expression especially that of heat shock protein 70 in sublethally damaged tumor cells. In this study, we evaluated the release of heat shock protein 70 into the serum of cancer-bearing patients directly after radiofrequency ablation. Sera of 22 patients undergoing radiofrequency ablation for the treatment of primary and secondary malignancies of the liver, kidney, and lung, as well as control sera of 20 patients undergoing diagnostic liver biopsy were analyzed using a manufactured heat shock protein 70 ELISA. A significant increase in serum levels of heat shock protein 70 was detectable in the patient cohort 1 day after radiofrequency ablation. More than a twofold increase was observed in nine out of 22 patients, which tended to correlate with favorable clinical outcome. No patient of the control group revealed a comparable increase. Radiofrequency ablation can lead to a release of heat shock protein 70 into the serum, which is transiently detectable 1 day after treatment. Elevated heat shock protein 70 serum levels may constitute a biomarker for favorable clinical outcome.",
keywords = "Adult, Aged, Aged, 80 and over, Biomarkers/metabolism, Biopsy, Catheter Ablation, Female, HSP70 Heat-Shock Proteins/blood, Humans, Liver/metabolism, Male, Middle Aged, Neoplasms/metabolism, Treatment Outcome, Young Adult",
author = "Haen, {Sebastian P} and C{\'e}cile Gouttefangeas and Diethard Schmidt and Andreas Boss and Stephan Clasen and {von Herbay}, Alexandra and Bora Kosan and Hermann Aebert and Pereira, {Philippe L} and Hans-Georg Rammensee",
year = "2011",
month = sep,
doi = "10.1007/s12192-011-0261-y",
language = "English",
volume = "16",
pages = "495--504",
journal = "CELL STRESS CHAPERON",
issn = "1355-8145",
publisher = "Springer Netherlands",
number = "5",

}

RIS

TY - JOUR

T1 - Elevated serum levels of heat shock protein 70 can be detected after radiofrequency ablation

AU - Haen, Sebastian P

AU - Gouttefangeas, Cécile

AU - Schmidt, Diethard

AU - Boss, Andreas

AU - Clasen, Stephan

AU - von Herbay, Alexandra

AU - Kosan, Bora

AU - Aebert, Hermann

AU - Pereira, Philippe L

AU - Rammensee, Hans-Georg

PY - 2011/9

Y1 - 2011/9

N2 - Due to their adjuvant effect and their ability to chaperone tumor-associated peptides, heat shock proteins constitute a potent alarm signal for the immune system and can lead to activation of anti-tumor T-cell immunity. Radiofrequency ablation has been reported to induce heat shock protein expression especially that of heat shock protein 70 in sublethally damaged tumor cells. In this study, we evaluated the release of heat shock protein 70 into the serum of cancer-bearing patients directly after radiofrequency ablation. Sera of 22 patients undergoing radiofrequency ablation for the treatment of primary and secondary malignancies of the liver, kidney, and lung, as well as control sera of 20 patients undergoing diagnostic liver biopsy were analyzed using a manufactured heat shock protein 70 ELISA. A significant increase in serum levels of heat shock protein 70 was detectable in the patient cohort 1 day after radiofrequency ablation. More than a twofold increase was observed in nine out of 22 patients, which tended to correlate with favorable clinical outcome. No patient of the control group revealed a comparable increase. Radiofrequency ablation can lead to a release of heat shock protein 70 into the serum, which is transiently detectable 1 day after treatment. Elevated heat shock protein 70 serum levels may constitute a biomarker for favorable clinical outcome.

AB - Due to their adjuvant effect and their ability to chaperone tumor-associated peptides, heat shock proteins constitute a potent alarm signal for the immune system and can lead to activation of anti-tumor T-cell immunity. Radiofrequency ablation has been reported to induce heat shock protein expression especially that of heat shock protein 70 in sublethally damaged tumor cells. In this study, we evaluated the release of heat shock protein 70 into the serum of cancer-bearing patients directly after radiofrequency ablation. Sera of 22 patients undergoing radiofrequency ablation for the treatment of primary and secondary malignancies of the liver, kidney, and lung, as well as control sera of 20 patients undergoing diagnostic liver biopsy were analyzed using a manufactured heat shock protein 70 ELISA. A significant increase in serum levels of heat shock protein 70 was detectable in the patient cohort 1 day after radiofrequency ablation. More than a twofold increase was observed in nine out of 22 patients, which tended to correlate with favorable clinical outcome. No patient of the control group revealed a comparable increase. Radiofrequency ablation can lead to a release of heat shock protein 70 into the serum, which is transiently detectable 1 day after treatment. Elevated heat shock protein 70 serum levels may constitute a biomarker for favorable clinical outcome.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Biomarkers/metabolism

KW - Biopsy

KW - Catheter Ablation

KW - Female

KW - HSP70 Heat-Shock Proteins/blood

KW - Humans

KW - Liver/metabolism

KW - Male

KW - Middle Aged

KW - Neoplasms/metabolism

KW - Treatment Outcome

KW - Young Adult

U2 - 10.1007/s12192-011-0261-y

DO - 10.1007/s12192-011-0261-y

M3 - SCORING: Journal article

C2 - 21442384

VL - 16

SP - 495

EP - 504

JO - CELL STRESS CHAPERON

JF - CELL STRESS CHAPERON

SN - 1355-8145

IS - 5

ER -