Elevated functional connectivity in a striatal-amygdala circuit in pathological gamblers
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Elevated functional connectivity in a striatal-amygdala circuit in pathological gamblers. / Peters, Jan; Miedl, Stephan Franz; Büchel, Christian.
in: PLOS ONE, Jahrgang 8, Nr. 9, 9, 2013, S. e74353.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Elevated functional connectivity in a striatal-amygdala circuit in pathological gamblers
AU - Peters, Jan
AU - Miedl, Stephan Franz
AU - Büchel, Christian
PY - 2013
Y1 - 2013
N2 - Both substance-based addiction and behavioural impulse control disorders (ICDs) have been associated with dysfunctions of the ventral striatum. Recent studies using functional connectivity techniques have revealed increased coupling of the ventral striatum with other limbic regions such as amygdala and orbitofrontal cortex in patients with substance abuse disorders and attention-deficit hyperactivity disorder. In the present study, we re-analyzed previously published functional magnetic resonance imaging data acquired in pathological gamblers and controls during value-based decision-making to investigate whether PG is associated with similar functional connectivity effects. In line with previous studies in other ICDs, we observed reliable increases in functional coupling between striatum and bilateral amygdala in gamblers vs. controls. Implications of these findings for neural models of self-control and addiction are discussed.
AB - Both substance-based addiction and behavioural impulse control disorders (ICDs) have been associated with dysfunctions of the ventral striatum. Recent studies using functional connectivity techniques have revealed increased coupling of the ventral striatum with other limbic regions such as amygdala and orbitofrontal cortex in patients with substance abuse disorders and attention-deficit hyperactivity disorder. In the present study, we re-analyzed previously published functional magnetic resonance imaging data acquired in pathological gamblers and controls during value-based decision-making to investigate whether PG is associated with similar functional connectivity effects. In line with previous studies in other ICDs, we observed reliable increases in functional coupling between striatum and bilateral amygdala in gamblers vs. controls. Implications of these findings for neural models of self-control and addiction are discussed.
KW - Amygdala
KW - Gambling
KW - Humans
KW - Magnetic Resonance Imaging
KW - Neostriatum
KW - Neural Pathways
U2 - 10.1371/journal.pone.0074353
DO - 10.1371/journal.pone.0074353
M3 - SCORING: Journal article
C2 - 24023940
VL - 8
SP - e74353
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 9
M1 - 9
ER -
