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Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients

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Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients. / Jiang, Huanhuan; Gebhardt, Christoffer; Umansky, Ludmila; Beckhove, Philipp; Schulze, Torsten J; Utikal, Jochen; Umansky, Viktor.

in: INT J CANCER, Jahrgang 136, Nr. 10, 15.05.2015, S. 2352-60.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jiang, H, Gebhardt, C, Umansky, L, Beckhove, P, Schulze, TJ, Utikal, J & Umansky, V 2015, 'Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients', INT J CANCER, Jg. 136, Nr. 10, S. 2352-60. https://doi.org/10.1002/ijc.29297

APA

Jiang, H., Gebhardt, C., Umansky, L., Beckhove, P., Schulze, T. J., Utikal, J., & Umansky, V. (2015). Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients. INT J CANCER, 136(10), 2352-60. https://doi.org/10.1002/ijc.29297

Vancouver

Jiang H, Gebhardt C, Umansky L, Beckhove P, Schulze TJ, Utikal J et al. Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients. INT J CANCER. 2015 Mai 15;136(10):2352-60. https://doi.org/10.1002/ijc.29297

Bibtex

@article{822bfb7f9f6a4b1c9aae7c7c9e833522,
title = "Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients",
abstract = "Chronic inflammation is considered to be one of the hallmarks for tumor initiation and progression. Moreover, a long-term production and accumulation of inflammatory factors lead to a local and systemic immunosuppression associated with cancer progression. However, the correlation between inflammatory mediators, immunosuppressive cells and the clinical outcome of malignant melanoma patients was poorly investigated. In this study, we performed a complex analysis of various inflammatory factors, myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) in the peripheral blood of patients suffering from malignant melanoma of different stages. We demonstrated that levels of serum IL-1β, IFN-γ and CXCL10 were significantly increased in advanced melanoma patients. In addition, these factors were found to be associated with an increased frequency of MDSCs and Tregs as compared to age- and gender-matched healthy donors. Importantly, advanced melanoma patients with signs of progression displayed markedly elevated concentrations of IL-1β and CXCL10 as compared to patients with stable disease. Moreover, an enrichment of circulating monocytic (Mo)-MDSCs significantly correlated with a decreased progression free survival of these patients. Our data highlight a complex association between circulating inflammatory mediators, Mo-MDSCs and the clinical outcome as well as suggest that their levels in patients with advanced melanoma are of important prognostic value allowing the identification of those with high risk of disease progression.",
keywords = "Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Cell Line, Tumor, Chemokine CXCL10, Disease Progression, Female, Humans, Interferon-alpha, Interleukin-1beta, Ipilimumab, Male, Melanoma, Middle Aged, Myeloid Cells, T-Lymphocytes, Regulatory, Journal Article, Research Support, Non-U.S. Gov't",
author = "Huanhuan Jiang and Christoffer Gebhardt and Ludmila Umansky and Philipp Beckhove and Schulze, {Torsten J} and Jochen Utikal and Viktor Umansky",
note = "{\textcopyright} 2014 UICC.",
year = "2015",
month = may,
day = "15",
doi = "10.1002/ijc.29297",
language = "English",
volume = "136",
pages = "2352--60",
journal = "INT J CANCER",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "10",

}

RIS

TY - JOUR

T1 - Elevated chronic inflammatory factors and myeloid-derived suppressor cells indicate poor prognosis in advanced melanoma patients

AU - Jiang, Huanhuan

AU - Gebhardt, Christoffer

AU - Umansky, Ludmila

AU - Beckhove, Philipp

AU - Schulze, Torsten J

AU - Utikal, Jochen

AU - Umansky, Viktor

N1 - © 2014 UICC.

PY - 2015/5/15

Y1 - 2015/5/15

N2 - Chronic inflammation is considered to be one of the hallmarks for tumor initiation and progression. Moreover, a long-term production and accumulation of inflammatory factors lead to a local and systemic immunosuppression associated with cancer progression. However, the correlation between inflammatory mediators, immunosuppressive cells and the clinical outcome of malignant melanoma patients was poorly investigated. In this study, we performed a complex analysis of various inflammatory factors, myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) in the peripheral blood of patients suffering from malignant melanoma of different stages. We demonstrated that levels of serum IL-1β, IFN-γ and CXCL10 were significantly increased in advanced melanoma patients. In addition, these factors were found to be associated with an increased frequency of MDSCs and Tregs as compared to age- and gender-matched healthy donors. Importantly, advanced melanoma patients with signs of progression displayed markedly elevated concentrations of IL-1β and CXCL10 as compared to patients with stable disease. Moreover, an enrichment of circulating monocytic (Mo)-MDSCs significantly correlated with a decreased progression free survival of these patients. Our data highlight a complex association between circulating inflammatory mediators, Mo-MDSCs and the clinical outcome as well as suggest that their levels in patients with advanced melanoma are of important prognostic value allowing the identification of those with high risk of disease progression.

AB - Chronic inflammation is considered to be one of the hallmarks for tumor initiation and progression. Moreover, a long-term production and accumulation of inflammatory factors lead to a local and systemic immunosuppression associated with cancer progression. However, the correlation between inflammatory mediators, immunosuppressive cells and the clinical outcome of malignant melanoma patients was poorly investigated. In this study, we performed a complex analysis of various inflammatory factors, myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) in the peripheral blood of patients suffering from malignant melanoma of different stages. We demonstrated that levels of serum IL-1β, IFN-γ and CXCL10 were significantly increased in advanced melanoma patients. In addition, these factors were found to be associated with an increased frequency of MDSCs and Tregs as compared to age- and gender-matched healthy donors. Importantly, advanced melanoma patients with signs of progression displayed markedly elevated concentrations of IL-1β and CXCL10 as compared to patients with stable disease. Moreover, an enrichment of circulating monocytic (Mo)-MDSCs significantly correlated with a decreased progression free survival of these patients. Our data highlight a complex association between circulating inflammatory mediators, Mo-MDSCs and the clinical outcome as well as suggest that their levels in patients with advanced melanoma are of important prognostic value allowing the identification of those with high risk of disease progression.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Antibodies, Monoclonal

KW - Cell Line, Tumor

KW - Chemokine CXCL10

KW - Disease Progression

KW - Female

KW - Humans

KW - Interferon-alpha

KW - Interleukin-1beta

KW - Ipilimumab

KW - Male

KW - Melanoma

KW - Middle Aged

KW - Myeloid Cells

KW - T-Lymphocytes, Regulatory

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/ijc.29297

DO - 10.1002/ijc.29297

M3 - SCORING: Journal article

C2 - 25353097

VL - 136

SP - 2352

EP - 2360

JO - INT J CANCER

JF - INT J CANCER

SN - 0020-7136

IS - 10

ER -