Eisenmangel bei Patienten mit chronischer Herzinsuffizienz – diagnostische Algorithmen und therapeutische Optionen anhand der aktuellen Studienlage
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Eisenmangel bei Patienten mit chronischer Herzinsuffizienz – diagnostische Algorithmen und therapeutische Optionen anhand der aktuellen Studienlage. / Doehner, Wolfram; Blankenberg, Stefan; Erdmann, Erland; Ertl, Georg; Hasenfuß, Gerd; Landmesser, Ulf; Pieske, Burkert; Schieffer, Bernhard; Schunkert, Heribert; von Haehling, Stephan; Zeiher, Andreas; Anker, Stefan D.
in: DEUT MED WOCHENSCHR, Jahrgang 142, Nr. 10, 05.2017, S. 752-757.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Eisenmangel bei Patienten mit chronischer Herzinsuffizienz – diagnostische Algorithmen und therapeutische Optionen anhand der aktuellen Studienlage
AU - Doehner, Wolfram
AU - Blankenberg, Stefan
AU - Erdmann, Erland
AU - Ertl, Georg
AU - Hasenfuß, Gerd
AU - Landmesser, Ulf
AU - Pieske, Burkert
AU - Schieffer, Bernhard
AU - Schunkert, Heribert
AU - von Haehling, Stephan
AU - Zeiher, Andreas
AU - Anker, Stefan D
N1 - © Georg Thieme Verlag KG Stuttgart · New York.
PY - 2017/5
Y1 - 2017/5
N2 - Iron deficiency (ID) occurs in up to 50% of patients with heart failure (HF). Even without presence of anaemia ID contributes to more severe symptoms, increased hospitalization and mortality. A number of randomized controlled trials demonstrated the clinical benefit of replenishment of iron stores with improvement of symptoms and fewer hospitalizations. Assessment of iron status should therefore become routine assessment in newly diagnosed and in symptomatic patients with HF. ID can be identified with simple and straightforward diagnostic steps. Assessment of Ferritin (indicating iron stores) and transferrin saturation (TSAT, indication capability to mobilise internal iron stores) are sufficient to detect ID. In this review a plain diagnostic algorithm for ID is suggested. Confounding factors for diagnosis and adequate treatment of ID in HF are discussed. A regular workup for iron deficiency parameters may benefit patients with heart failure by providing symptomatic improvements and fewer hospitalizations.
AB - Iron deficiency (ID) occurs in up to 50% of patients with heart failure (HF). Even without presence of anaemia ID contributes to more severe symptoms, increased hospitalization and mortality. A number of randomized controlled trials demonstrated the clinical benefit of replenishment of iron stores with improvement of symptoms and fewer hospitalizations. Assessment of iron status should therefore become routine assessment in newly diagnosed and in symptomatic patients with HF. ID can be identified with simple and straightforward diagnostic steps. Assessment of Ferritin (indicating iron stores) and transferrin saturation (TSAT, indication capability to mobilise internal iron stores) are sufficient to detect ID. In this review a plain diagnostic algorithm for ID is suggested. Confounding factors for diagnosis and adequate treatment of ID in HF are discussed. A regular workup for iron deficiency parameters may benefit patients with heart failure by providing symptomatic improvements and fewer hospitalizations.
KW - Algorithms
KW - Deficiency Diseases/complications
KW - Heart Failure/complications
KW - Humans
KW - Iron/deficiency
KW - Randomized Controlled Trials as Topic
U2 - 10.1055/s-0043-100900
DO - 10.1055/s-0043-100900
M3 - SCORING: Review
C2 - 28303555
VL - 142
SP - 752
EP - 757
JO - DEUT MED WOCHENSCHR
JF - DEUT MED WOCHENSCHR
SN - 0012-0472
IS - 10
ER -