Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection.
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Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection. / Kolbaum, J; Eschbach, M-L; Steeg, C; Jacobs, T; Fleischer, Bernhard; Breloer, M.
in: PARASITE IMMUNOL, Jahrgang 34, Nr. 7, 7, 2012, S. 388-393.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Efficient control of Plasmodium yoelii infection in BALB/c and C57BL/6 mice with pre-existing Strongyloides ratti infection.
AU - Kolbaum, J
AU - Eschbach, M-L
AU - Steeg, C
AU - Jacobs, T
AU - Fleischer, Bernhard
AU - Breloer, M
PY - 2012
Y1 - 2012
N2 - About 225 million malaria cases have been reported worldwide in 2009, and one-third of the world's population is infected with parasitic helminths. As helminths and Plasmodium are co-endemic, concurrent infections frequently occur. Helminths have been shown to modulate the host's immune response; therefore, pre-existing helminth infections may interfere with the efficient immune response to Plasmodium. To study the interaction between helminths and Plasmodium, we established a murine model of co-infection using the gastrointestinal nematode Strongyloides ratti and Plasmodium yoelii. We show that a pre-existing Strongyloides infection slightly enhanced peak parasitemia and weight loss in P. yoelii-infected BALB/c mice, while disease progression was not altered in co-infected C57BL/6 mice. The Plasmodium-induced IFN-? production and final clearance of Plasmodium infection were not affected by S. ratti co-infection in both C57BL/6 and BALB/c mice. Interestingly, the T helper cell (Th) 2 response induced by S. ratti was significantly suppressed upon P. yoelii co-infection. This suppressed Th2 response, however, was still sufficient to allow expulsion of S. ratti parasitic adults. Taken together, we provide evidence that simultaneous presence of helminth and protist parasites does not interfere with efficient host defence in our co-infection model although changes in Th responses were observed.
AB - About 225 million malaria cases have been reported worldwide in 2009, and one-third of the world's population is infected with parasitic helminths. As helminths and Plasmodium are co-endemic, concurrent infections frequently occur. Helminths have been shown to modulate the host's immune response; therefore, pre-existing helminth infections may interfere with the efficient immune response to Plasmodium. To study the interaction between helminths and Plasmodium, we established a murine model of co-infection using the gastrointestinal nematode Strongyloides ratti and Plasmodium yoelii. We show that a pre-existing Strongyloides infection slightly enhanced peak parasitemia and weight loss in P. yoelii-infected BALB/c mice, while disease progression was not altered in co-infected C57BL/6 mice. The Plasmodium-induced IFN-? production and final clearance of Plasmodium infection were not affected by S. ratti co-infection in both C57BL/6 and BALB/c mice. Interestingly, the T helper cell (Th) 2 response induced by S. ratti was significantly suppressed upon P. yoelii co-infection. This suppressed Th2 response, however, was still sufficient to allow expulsion of S. ratti parasitic adults. Taken together, we provide evidence that simultaneous presence of helminth and protist parasites does not interfere with efficient host defence in our co-infection model although changes in Th responses were observed.
KW - Animals
KW - Female
KW - Disease Models, Animal
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Inbred C57BL
KW - Interferon-gamma/secretion
KW - Parasite Load
KW - Strongyloides ratti/immunology
KW - Th2 Cells/immunology
KW - Immune Tolerance
KW - Coinfection/immunology/prevention & control
KW - Malaria/immunology/parasitology
KW - Parasitemia/parasitology
KW - Plasmodium yoelii/immunology
KW - Strongyloidiasis/immunology/parasitology
KW - Animals
KW - Female
KW - Disease Models, Animal
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Inbred C57BL
KW - Interferon-gamma/secretion
KW - Parasite Load
KW - Strongyloides ratti/immunology
KW - Th2 Cells/immunology
KW - Immune Tolerance
KW - Coinfection/immunology/prevention & control
KW - Malaria/immunology/parasitology
KW - Parasitemia/parasitology
KW - Plasmodium yoelii/immunology
KW - Strongyloidiasis/immunology/parasitology
M3 - SCORING: Journal article
VL - 34
SP - 388
EP - 393
JO - PARASITE IMMUNOL
JF - PARASITE IMMUNOL
SN - 0141-9838
IS - 7
M1 - 7
ER -
