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Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial

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Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial. / Bachmann, Kai A; Trepte, Constantin Jc; Tomkötter, Lena; Hinsch, Andrea; Stork, Jan-Henrich; Bergmann, Wilken; Heidelmann, Lena; Strate, Tim; Goetz, Alwin E; Reuter, Daniel A; Izbicki, Jakob R; Mann, Oliver.

in: CRIT CARE, Jahrgang 17, Nr. 6, 05.12.2013, S. R281.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bachmann, KA, Trepte, CJ, Tomkötter, L, Hinsch, A, Stork, J-H, Bergmann, W, Heidelmann, L, Strate, T, Goetz, AE, Reuter, DA, Izbicki, JR & Mann, O 2013, 'Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial', CRIT CARE, Jg. 17, Nr. 6, S. R281. https://doi.org/10.1186/cc13142

APA

Bachmann, K. A., Trepte, C. J., Tomkötter, L., Hinsch, A., Stork, J-H., Bergmann, W., Heidelmann, L., Strate, T., Goetz, A. E., Reuter, D. A., Izbicki, J. R., & Mann, O. (2013). Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial. CRIT CARE, 17(6), R281. https://doi.org/10.1186/cc13142

Vancouver

Bachmann KA, Trepte CJ, Tomkötter L, Hinsch A, Stork J-H, Bergmann W et al. Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial. CRIT CARE. 2013 Dez 5;17(6):R281. https://doi.org/10.1186/cc13142

Bibtex

@article{1f853baba9a44691b769992f5436e908,
title = "Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial",
abstract = "INTRODUCTION: Severe acute pancreatitis is still a potentially life threatening disease with high mortality. The aim of this study was to evaluate the therapeutic effect of thoracic epidural anaesthesia (TEA) on survival, microcirculation, tissue oxygenation and histopathologic damage in an experimental animal model of severe acute pancreatitis in a prospective animal study.METHODS: In this study, 34 pigs were randomly assigned into 2 treatment groups. After severe acute pancreatitis was induced by intraductal injection of glycodesoxycholic acid in Group 1 (n = 17) bupivacaine (0.5%; bolus injection 2 ml, continuous infusion 4 ml/h) was applied via TEA. In Group 2 (n = 17) no TEA was applied. During a period of 6 hours after induction, tissue oxygen tension (tpO2) in the pancreas and pancreatic microcirculation was assessed. Thereafter animals were observed for 7 days followed by sacrification and histopathologic examination.RESULTS: Survival rate after 7 days was 82% in Group 1 (TEA) versus 29% in Group 2: (Control) (P <0.05). Group 1 (TEA) also showed a significantly superior microcirculation (1,608 ± 374 AU versus 1,121 ± 510 AU; P <0.05) and tissue oxygenation (215 ± 64 mmHg versus 138 ± 90 mmHG; P <0.05) as compared to Group 2 (Control). Consecutively, tissue damage in Group 1 was reduced in the histopathologic scoring (5.5 (3 to 8) versus 8 (5.5 to 10); P <0.05).CONCLUSIONS: TEA led to improved survival, enhanced microcirculatory perfusion and tissue oxygenation and resulted in less histopathologic tissue-damage in an experimental animal model of severe acute pancreatitis.",
author = "Bachmann, {Kai A} and Trepte, {Constantin Jc} and Lena Tomk{\"o}tter and Andrea Hinsch and Jan-Henrich Stork and Wilken Bergmann and Lena Heidelmann and Tim Strate and Goetz, {Alwin E} and Reuter, {Daniel A} and Izbicki, {Jakob R} and Oliver Mann",
year = "2013",
month = dec,
day = "5",
doi = "10.1186/cc13142",
language = "English",
volume = "17",
pages = "R281",
journal = "CRIT CARE",
issn = "1364-8535",
publisher = "Springer Science + Business Media",
number = "6",

}

RIS

TY - JOUR

T1 - Effects of thoracic epidural anesthesia on survival and microcirculation in severe acute pancreatitis: a randomized experimental trial

AU - Bachmann, Kai A

AU - Trepte, Constantin Jc

AU - Tomkötter, Lena

AU - Hinsch, Andrea

AU - Stork, Jan-Henrich

AU - Bergmann, Wilken

AU - Heidelmann, Lena

AU - Strate, Tim

AU - Goetz, Alwin E

AU - Reuter, Daniel A

AU - Izbicki, Jakob R

AU - Mann, Oliver

PY - 2013/12/5

Y1 - 2013/12/5

N2 - INTRODUCTION: Severe acute pancreatitis is still a potentially life threatening disease with high mortality. The aim of this study was to evaluate the therapeutic effect of thoracic epidural anaesthesia (TEA) on survival, microcirculation, tissue oxygenation and histopathologic damage in an experimental animal model of severe acute pancreatitis in a prospective animal study.METHODS: In this study, 34 pigs were randomly assigned into 2 treatment groups. After severe acute pancreatitis was induced by intraductal injection of glycodesoxycholic acid in Group 1 (n = 17) bupivacaine (0.5%; bolus injection 2 ml, continuous infusion 4 ml/h) was applied via TEA. In Group 2 (n = 17) no TEA was applied. During a period of 6 hours after induction, tissue oxygen tension (tpO2) in the pancreas and pancreatic microcirculation was assessed. Thereafter animals were observed for 7 days followed by sacrification and histopathologic examination.RESULTS: Survival rate after 7 days was 82% in Group 1 (TEA) versus 29% in Group 2: (Control) (P <0.05). Group 1 (TEA) also showed a significantly superior microcirculation (1,608 ± 374 AU versus 1,121 ± 510 AU; P <0.05) and tissue oxygenation (215 ± 64 mmHg versus 138 ± 90 mmHG; P <0.05) as compared to Group 2 (Control). Consecutively, tissue damage in Group 1 was reduced in the histopathologic scoring (5.5 (3 to 8) versus 8 (5.5 to 10); P <0.05).CONCLUSIONS: TEA led to improved survival, enhanced microcirculatory perfusion and tissue oxygenation and resulted in less histopathologic tissue-damage in an experimental animal model of severe acute pancreatitis.

AB - INTRODUCTION: Severe acute pancreatitis is still a potentially life threatening disease with high mortality. The aim of this study was to evaluate the therapeutic effect of thoracic epidural anaesthesia (TEA) on survival, microcirculation, tissue oxygenation and histopathologic damage in an experimental animal model of severe acute pancreatitis in a prospective animal study.METHODS: In this study, 34 pigs were randomly assigned into 2 treatment groups. After severe acute pancreatitis was induced by intraductal injection of glycodesoxycholic acid in Group 1 (n = 17) bupivacaine (0.5%; bolus injection 2 ml, continuous infusion 4 ml/h) was applied via TEA. In Group 2 (n = 17) no TEA was applied. During a period of 6 hours after induction, tissue oxygen tension (tpO2) in the pancreas and pancreatic microcirculation was assessed. Thereafter animals were observed for 7 days followed by sacrification and histopathologic examination.RESULTS: Survival rate after 7 days was 82% in Group 1 (TEA) versus 29% in Group 2: (Control) (P <0.05). Group 1 (TEA) also showed a significantly superior microcirculation (1,608 ± 374 AU versus 1,121 ± 510 AU; P <0.05) and tissue oxygenation (215 ± 64 mmHg versus 138 ± 90 mmHG; P <0.05) as compared to Group 2 (Control). Consecutively, tissue damage in Group 1 was reduced in the histopathologic scoring (5.5 (3 to 8) versus 8 (5.5 to 10); P <0.05).CONCLUSIONS: TEA led to improved survival, enhanced microcirculatory perfusion and tissue oxygenation and resulted in less histopathologic tissue-damage in an experimental animal model of severe acute pancreatitis.

U2 - 10.1186/cc13142

DO - 10.1186/cc13142

M3 - SCORING: Journal article

C2 - 24314012

VL - 17

SP - R281

JO - CRIT CARE

JF - CRIT CARE

SN - 1364-8535

IS - 6

ER -