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Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women

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Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women. / Sommer, Tobias; Richter, Katharina; Singer, Franziska; Derntl, Birgit; Rune, Gabriele M; Diekhof, Esther; Bayer, Janine.

in: PSYCHOPHARMACOLOGY, Jahrgang 235, Nr. 12, 12.2018, S. 3465-3477.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sommer, T, Richter, K, Singer, F, Derntl, B, Rune, GM, Diekhof, E & Bayer, J 2018, 'Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women', PSYCHOPHARMACOLOGY, Jg. 235, Nr. 12, S. 3465-3477. https://doi.org/10.1007/s00213-018-5061-y

APA

Sommer, T., Richter, K., Singer, F., Derntl, B., Rune, G. M., Diekhof, E., & Bayer, J. (2018). Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women. PSYCHOPHARMACOLOGY, 235(12), 3465-3477. https://doi.org/10.1007/s00213-018-5061-y

Vancouver

Sommer T, Richter K, Singer F, Derntl B, Rune GM, Diekhof E et al. Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women. PSYCHOPHARMACOLOGY. 2018 Dez;235(12):3465-3477. https://doi.org/10.1007/s00213-018-5061-y

Bibtex

@article{3e48ab43db374dcea8732034d9c10f3b,
title = "Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women",
abstract = "17-Beta-estradiol (E2) stimulates neural plasticity and dopaminergic transmission in the prefrontal cortex, which is critically involved in attentional control, working memory, and other executive functions. Studies investigating E2's actions on prefrontally mediated behavior in the course of the menstrual cycle or during hormone replacement therapy are inconclusive, with numerous null findings as well as beneficial and detrimental effects. The current study focused on the effect of E2 on attentional performance, as animal studies indicate that supraphysiological doses (i.e., above estrous cycle levels) of E2 have beneficial effects on measures of attention in female rodents. To translate these findings to humans, we administered 12 mg E2-valerate or placebo orally to 34 naturally cycling women in the low-hormone early follicular phase using a randomized, double-blinded, pre-post design. Behavioral performance was tested twice during baseline and E2 peak, where E2 levels reached mildly supraphysiological levels in the E2 group. Aside from mainly prefrontally mediated tasks of attention, working memory, and other executive functions, we employed tasks of affectively modulated attention, emotion recognition, and verbal memory. E2 administration had a significant, but subtle negative impact on general processing speed and working memory performance. These effects could be related to an overstimulation of dopaminergic transmission. The negative effect of supraphysiological E2 on working memory connects well to animal literature. There were no effects on attentional performance or any other measure. This could be explained by different E2 levels being optimal for changing behavioral performance in specific tasks, which likely depends on the brain regions involved.",
keywords = "Administration, Oral, Adult, Animals, Double-Blind Method, Emotions, Estradiol, Estrogens, Estrous Cycle, Executive Function, Female, Humans, Memory, Short-Term, Menstrual Cycle, Prefrontal Cortex, Psychomotor Performance, Young Adult, Journal Article, Randomized Controlled Trial",
author = "Tobias Sommer and Katharina Richter and Franziska Singer and Birgit Derntl and Rune, {Gabriele M} and Esther Diekhof and Janine Bayer",
year = "2018",
month = dec,
doi = "10.1007/s00213-018-5061-y",
language = "English",
volume = "235",
pages = "3465--3477",
journal = "PSYCHOPHARMACOLOGY",
issn = "0033-3158",
publisher = "Springer",
number = "12",

}

RIS

TY - JOUR

T1 - Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women

AU - Sommer, Tobias

AU - Richter, Katharina

AU - Singer, Franziska

AU - Derntl, Birgit

AU - Rune, Gabriele M

AU - Diekhof, Esther

AU - Bayer, Janine

PY - 2018/12

Y1 - 2018/12

N2 - 17-Beta-estradiol (E2) stimulates neural plasticity and dopaminergic transmission in the prefrontal cortex, which is critically involved in attentional control, working memory, and other executive functions. Studies investigating E2's actions on prefrontally mediated behavior in the course of the menstrual cycle or during hormone replacement therapy are inconclusive, with numerous null findings as well as beneficial and detrimental effects. The current study focused on the effect of E2 on attentional performance, as animal studies indicate that supraphysiological doses (i.e., above estrous cycle levels) of E2 have beneficial effects on measures of attention in female rodents. To translate these findings to humans, we administered 12 mg E2-valerate or placebo orally to 34 naturally cycling women in the low-hormone early follicular phase using a randomized, double-blinded, pre-post design. Behavioral performance was tested twice during baseline and E2 peak, where E2 levels reached mildly supraphysiological levels in the E2 group. Aside from mainly prefrontally mediated tasks of attention, working memory, and other executive functions, we employed tasks of affectively modulated attention, emotion recognition, and verbal memory. E2 administration had a significant, but subtle negative impact on general processing speed and working memory performance. These effects could be related to an overstimulation of dopaminergic transmission. The negative effect of supraphysiological E2 on working memory connects well to animal literature. There were no effects on attentional performance or any other measure. This could be explained by different E2 levels being optimal for changing behavioral performance in specific tasks, which likely depends on the brain regions involved.

AB - 17-Beta-estradiol (E2) stimulates neural plasticity and dopaminergic transmission in the prefrontal cortex, which is critically involved in attentional control, working memory, and other executive functions. Studies investigating E2's actions on prefrontally mediated behavior in the course of the menstrual cycle or during hormone replacement therapy are inconclusive, with numerous null findings as well as beneficial and detrimental effects. The current study focused on the effect of E2 on attentional performance, as animal studies indicate that supraphysiological doses (i.e., above estrous cycle levels) of E2 have beneficial effects on measures of attention in female rodents. To translate these findings to humans, we administered 12 mg E2-valerate or placebo orally to 34 naturally cycling women in the low-hormone early follicular phase using a randomized, double-blinded, pre-post design. Behavioral performance was tested twice during baseline and E2 peak, where E2 levels reached mildly supraphysiological levels in the E2 group. Aside from mainly prefrontally mediated tasks of attention, working memory, and other executive functions, we employed tasks of affectively modulated attention, emotion recognition, and verbal memory. E2 administration had a significant, but subtle negative impact on general processing speed and working memory performance. These effects could be related to an overstimulation of dopaminergic transmission. The negative effect of supraphysiological E2 on working memory connects well to animal literature. There were no effects on attentional performance or any other measure. This could be explained by different E2 levels being optimal for changing behavioral performance in specific tasks, which likely depends on the brain regions involved.

KW - Administration, Oral

KW - Adult

KW - Animals

KW - Double-Blind Method

KW - Emotions

KW - Estradiol

KW - Estrogens

KW - Estrous Cycle

KW - Executive Function

KW - Female

KW - Humans

KW - Memory, Short-Term

KW - Menstrual Cycle

KW - Prefrontal Cortex

KW - Psychomotor Performance

KW - Young Adult

KW - Journal Article

KW - Randomized Controlled Trial

U2 - 10.1007/s00213-018-5061-y

DO - 10.1007/s00213-018-5061-y

M3 - SCORING: Journal article

C2 - 30306229

VL - 235

SP - 3465

EP - 3477

JO - PSYCHOPHARMACOLOGY

JF - PSYCHOPHARMACOLOGY

SN - 0033-3158

IS - 12

ER -