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Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain

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Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain. / Dührsen, Lasse; Simons, Sinno H P; Dzietko, Mark; Genz, Kerstin; Bendix, Ivo; Boos, Vinzenz; Sifringer, Marco; Tibboel, Dick; Felderhoff-Mueser, Ursula.

in: NEONATOLOGY, Jahrgang 103, Nr. 1, 01.01.2013, S. 35-43.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Dührsen, L, Simons, SHP, Dzietko, M, Genz, K, Bendix, I, Boos, V, Sifringer, M, Tibboel, D & Felderhoff-Mueser, U 2013, 'Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain', NEONATOLOGY, Jg. 103, Nr. 1, S. 35-43. https://doi.org/10.1159/000341769

APA

Dührsen, L., Simons, S. H. P., Dzietko, M., Genz, K., Bendix, I., Boos, V., Sifringer, M., Tibboel, D., & Felderhoff-Mueser, U. (2013). Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain. NEONATOLOGY, 103(1), 35-43. https://doi.org/10.1159/000341769

Vancouver

Dührsen L, Simons SHP, Dzietko M, Genz K, Bendix I, Boos V et al. Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain. NEONATOLOGY. 2013 Jan 1;103(1):35-43. https://doi.org/10.1159/000341769

Bibtex

@article{1a4d6958adb74b718e06de075c9c3d6c,
title = "Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain",
abstract = "BACKGROUND: Untreated exposure to pain in preterm neonates might damage the vulnerable premature brain and alter development. Pain treatment is limited because analgesic agents may also have adverse neurodevelopmental consequences in newborns.OBJECTIVE: To study the effects of neonatal pain and morphine treatment on the developing brain in a neonatal rat model.METHODS: Newborn rats were randomly assigned to: treatment with formalin injections (group 1), saline injections (group 2) and controls receiving no injections (group 3). Treatment was given on postnatal days 1-3 (model A), 1-5 (model B) and 10-12 (model C). Brains were studied histologically and protein expression was evaluated (protein kinase C epsilon and doublecortin). Effects of preemptive morphine treatment were studied in the same models (models A+M and B+M).RESULTS: Formalin injections resulted in increased apoptotic scores in models A and B. Saline injections increased the number of degenerative cells only in model B. Morphine showed protective effects in formalin-treated animals of model A+M and saline-treated animals of model B+M only. In model C, no neurodegenerative effects were detected. The protein expression of doublecortin showed a pain-related upregulation in the thalamus region, whereas protein kinase C epsilon expression was upregulated in the cortex.CONCLUSIONS: Severe inflammatory pain and pain caused by repetitive injections in neonatal rats may cause major changes in the developing brain during the first week of life. Morphine may only protect the newborn brain against these changes in specific situations.",
keywords = "Age Factors, Animals, Animals, Newborn, Brain, Disease Models, Animal, Formaldehyde, Morphine, Narcotics, Nerve Degeneration, Pain, Random Allocation, Rats, Rats, Wistar, Recurrence",
author = "Lasse D{\"u}hrsen and Simons, {Sinno H P} and Mark Dzietko and Kerstin Genz and Ivo Bendix and Vinzenz Boos and Marco Sifringer and Dick Tibboel and Ursula Felderhoff-Mueser",
note = "Copyright {\textcopyright} 2012 S. Karger AG, Basel.",
year = "2013",
month = jan,
day = "1",
doi = "10.1159/000341769",
language = "English",
volume = "103",
pages = "35--43",
journal = "NEONATOLOGY",
issn = "1661-7800",
publisher = "S. Karger AG",
number = "1",

}

RIS

TY - JOUR

T1 - Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain

AU - Dührsen, Lasse

AU - Simons, Sinno H P

AU - Dzietko, Mark

AU - Genz, Kerstin

AU - Bendix, Ivo

AU - Boos, Vinzenz

AU - Sifringer, Marco

AU - Tibboel, Dick

AU - Felderhoff-Mueser, Ursula

N1 - Copyright © 2012 S. Karger AG, Basel.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - BACKGROUND: Untreated exposure to pain in preterm neonates might damage the vulnerable premature brain and alter development. Pain treatment is limited because analgesic agents may also have adverse neurodevelopmental consequences in newborns.OBJECTIVE: To study the effects of neonatal pain and morphine treatment on the developing brain in a neonatal rat model.METHODS: Newborn rats were randomly assigned to: treatment with formalin injections (group 1), saline injections (group 2) and controls receiving no injections (group 3). Treatment was given on postnatal days 1-3 (model A), 1-5 (model B) and 10-12 (model C). Brains were studied histologically and protein expression was evaluated (protein kinase C epsilon and doublecortin). Effects of preemptive morphine treatment were studied in the same models (models A+M and B+M).RESULTS: Formalin injections resulted in increased apoptotic scores in models A and B. Saline injections increased the number of degenerative cells only in model B. Morphine showed protective effects in formalin-treated animals of model A+M and saline-treated animals of model B+M only. In model C, no neurodegenerative effects were detected. The protein expression of doublecortin showed a pain-related upregulation in the thalamus region, whereas protein kinase C epsilon expression was upregulated in the cortex.CONCLUSIONS: Severe inflammatory pain and pain caused by repetitive injections in neonatal rats may cause major changes in the developing brain during the first week of life. Morphine may only protect the newborn brain against these changes in specific situations.

AB - BACKGROUND: Untreated exposure to pain in preterm neonates might damage the vulnerable premature brain and alter development. Pain treatment is limited because analgesic agents may also have adverse neurodevelopmental consequences in newborns.OBJECTIVE: To study the effects of neonatal pain and morphine treatment on the developing brain in a neonatal rat model.METHODS: Newborn rats were randomly assigned to: treatment with formalin injections (group 1), saline injections (group 2) and controls receiving no injections (group 3). Treatment was given on postnatal days 1-3 (model A), 1-5 (model B) and 10-12 (model C). Brains were studied histologically and protein expression was evaluated (protein kinase C epsilon and doublecortin). Effects of preemptive morphine treatment were studied in the same models (models A+M and B+M).RESULTS: Formalin injections resulted in increased apoptotic scores in models A and B. Saline injections increased the number of degenerative cells only in model B. Morphine showed protective effects in formalin-treated animals of model A+M and saline-treated animals of model B+M only. In model C, no neurodegenerative effects were detected. The protein expression of doublecortin showed a pain-related upregulation in the thalamus region, whereas protein kinase C epsilon expression was upregulated in the cortex.CONCLUSIONS: Severe inflammatory pain and pain caused by repetitive injections in neonatal rats may cause major changes in the developing brain during the first week of life. Morphine may only protect the newborn brain against these changes in specific situations.

KW - Age Factors

KW - Animals

KW - Animals, Newborn

KW - Brain

KW - Disease Models, Animal

KW - Formaldehyde

KW - Morphine

KW - Narcotics

KW - Nerve Degeneration

KW - Pain

KW - Random Allocation

KW - Rats

KW - Rats, Wistar

KW - Recurrence

U2 - 10.1159/000341769

DO - 10.1159/000341769

M3 - SCORING: Journal article

C2 - 23037996

VL - 103

SP - 35

EP - 43

JO - NEONATOLOGY

JF - NEONATOLOGY

SN - 1661-7800

IS - 1

ER -