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Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs)

Standard

Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs). / Demestre, Maria; Terzi, Menderes Yusuf; Mautner, Victor-Felix; Vajkoczy, Peter; Kurtz, Andreas; Piña, Ana Luisa.

in: J NEURO-ONCOL, Jahrgang 115, Nr. 3, 01.12.2013, S. 391-9.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Demestre, M, Terzi, MY, Mautner, V-F, Vajkoczy, P, Kurtz, A & Piña, AL 2013, 'Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs)', J NEURO-ONCOL, Jg. 115, Nr. 3, S. 391-9. https://doi.org/10.1007/s11060-013-1252-x

APA

Demestre, M., Terzi, M. Y., Mautner, V-F., Vajkoczy, P., Kurtz, A., & Piña, A. L. (2013). Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs). J NEURO-ONCOL, 115(3), 391-9. https://doi.org/10.1007/s11060-013-1252-x

Vancouver

Demestre M, Terzi MY, Mautner V-F, Vajkoczy P, Kurtz A, Piña AL. Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs). J NEURO-ONCOL. 2013 Dez 1;115(3):391-9. https://doi.org/10.1007/s11060-013-1252-x

Bibtex

@article{a14ba972747d46e49db4add65da74404,
title = "Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs)",
abstract = "Neurofibromatosis type 1 (NF1) is an inherited genetic disease affecting 1 in 3,500 individuals. A prominent feature of NF1 is the formation of benign tumours of the peripheral nerve sheath (neurofibromas). However, these can become malignant and form highly metastatic malignant peripheral nerve sheath tumours (MPNST), which are usually fatal despite aggressive surgery, chemotherapy, and radiotherapy. Recent studies have shown that pigment epithelium-derived factor (PEDF) can induce differentiation and inhibit angiogenesis in several kinds of tumours. The present study was designed to determine the in vitro and in vivo effects of PEDF on MPNST angiogenesis and tumour growth. PEDF inhibited proliferation and augmented apoptosis in S462 MPNST cells after 48 h of treatment in culture. In xenografts of S462 MPNST cells in athymic nude mice, PEDF suppressed MPNST tumour burden, due mainly to inhibition of angiogenesis. These results demonstrate for the first time inhibitory effects of PEDF on the growth of human MPNST via induction of anti-angiogenesis and apoptosis. Our results suggest that PEDF could be a novel approach for future therapeutic purposes against MPNST.",
author = "Maria Demestre and Terzi, {Menderes Yusuf} and Victor-Felix Mautner and Peter Vajkoczy and Andreas Kurtz and Pi{\~n}a, {Ana Luisa}",
year = "2013",
month = dec,
day = "1",
doi = "10.1007/s11060-013-1252-x",
language = "English",
volume = "115",
pages = "391--9",
journal = "J NEURO-ONCOL",
issn = "0167-594X",
publisher = "Kluwer Academic Publishers",
number = "3",

}

RIS

TY - JOUR

T1 - Effects of pigment epithelium derived factor (PEDF) on malignant peripheral nerve sheath tumours (MPNSTs)

AU - Demestre, Maria

AU - Terzi, Menderes Yusuf

AU - Mautner, Victor-Felix

AU - Vajkoczy, Peter

AU - Kurtz, Andreas

AU - Piña, Ana Luisa

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Neurofibromatosis type 1 (NF1) is an inherited genetic disease affecting 1 in 3,500 individuals. A prominent feature of NF1 is the formation of benign tumours of the peripheral nerve sheath (neurofibromas). However, these can become malignant and form highly metastatic malignant peripheral nerve sheath tumours (MPNST), which are usually fatal despite aggressive surgery, chemotherapy, and radiotherapy. Recent studies have shown that pigment epithelium-derived factor (PEDF) can induce differentiation and inhibit angiogenesis in several kinds of tumours. The present study was designed to determine the in vitro and in vivo effects of PEDF on MPNST angiogenesis and tumour growth. PEDF inhibited proliferation and augmented apoptosis in S462 MPNST cells after 48 h of treatment in culture. In xenografts of S462 MPNST cells in athymic nude mice, PEDF suppressed MPNST tumour burden, due mainly to inhibition of angiogenesis. These results demonstrate for the first time inhibitory effects of PEDF on the growth of human MPNST via induction of anti-angiogenesis and apoptosis. Our results suggest that PEDF could be a novel approach for future therapeutic purposes against MPNST.

AB - Neurofibromatosis type 1 (NF1) is an inherited genetic disease affecting 1 in 3,500 individuals. A prominent feature of NF1 is the formation of benign tumours of the peripheral nerve sheath (neurofibromas). However, these can become malignant and form highly metastatic malignant peripheral nerve sheath tumours (MPNST), which are usually fatal despite aggressive surgery, chemotherapy, and radiotherapy. Recent studies have shown that pigment epithelium-derived factor (PEDF) can induce differentiation and inhibit angiogenesis in several kinds of tumours. The present study was designed to determine the in vitro and in vivo effects of PEDF on MPNST angiogenesis and tumour growth. PEDF inhibited proliferation and augmented apoptosis in S462 MPNST cells after 48 h of treatment in culture. In xenografts of S462 MPNST cells in athymic nude mice, PEDF suppressed MPNST tumour burden, due mainly to inhibition of angiogenesis. These results demonstrate for the first time inhibitory effects of PEDF on the growth of human MPNST via induction of anti-angiogenesis and apoptosis. Our results suggest that PEDF could be a novel approach for future therapeutic purposes against MPNST.

U2 - 10.1007/s11060-013-1252-x

DO - 10.1007/s11060-013-1252-x

M3 - SCORING: Journal article

C2 - 24078214

VL - 115

SP - 391

EP - 399

JO - J NEURO-ONCOL

JF - J NEURO-ONCOL

SN - 0167-594X

IS - 3

ER -