Effects of Buthus martensii (Karsch) scorpion venom on sodium currents in rat anterior pituitary (GH3/B6) cells.

Christiane K. Bauer; B Krylov; P A Zhou; J R Schwarz

doi:10.1016/0041-0101(92)90852-v

Effects of Buthus martensii (Karsch) scorpion venom on sodium currents in rat anterior pituitary (GH3/B6) cells.

Standard

Effects of Buthus martensii (Karsch) scorpion venom on sodium currents in rat anterior pituitary (GH3/B6) cells. / Bauer, Christiane K.; Krylov, B; Zhou, P A; Schwarz, J R.

in: TOXICON, Jahrgang 30, Nr. 5-6, 5-6, 1992, S. 581-589.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bauer, CK, Krylov, B, Zhou, PA & Schwarz, JR 1992, 'Effects of Buthus martensii (Karsch) scorpion venom on sodium currents in rat anterior pituitary (GH3/B6) cells.', TOXICON, Jg. 30, Nr. 5-6, 5-6, S. 581-589. https://doi.org/10.1016/0041-0101(92)90852-v

APA

Bauer, C. K., Krylov, B., Zhou, P. A., & Schwarz, J. R. (1992). Effects of Buthus martensii (Karsch) scorpion venom on sodium currents in rat anterior pituitary (GH3/B6) cells. TOXICON, 30(5-6), 581-589. [5-6]. https://doi.org/10.1016/0041-0101(92)90852-v

Vancouver

Bauer CK, Krylov B, Zhou PA, Schwarz JR. Effects of Buthus martensii (Karsch) scorpion venom on sodium currents in rat anterior pituitary (GH3/B6) cells. TOXICON. 1992;30(5-6):581-589. 5-6. https://doi.org/10.1016/0041-0101(92)90852-v

Bibtex

@article{8039d4ada5a249d395526c47c171ddf0,

title = "Effects of Buthus martensii (Karsch) scorpion venom on sodium currents in rat anterior pituitary (GH3/B6) cells.",

abstract = "The effects of two fractions (II, containing anti-insect toxins, and III, containing eight anti-mammal toxins) isolated from the venom of the Old World scorpion Buthus martensii (Karsch) on Na+ currents of rat anterior pituitary cells (GH3/B6 cells) were investigated using the whole-cell configuration of the patch clamp technique. Fraction II induced a temporary, and fraction III a permanent increase of the Na+ current amplitude. Application of each of the venom fractions resulted in a flattening of the curve relating steady state Na+ inactivation to membrane potential. In addition, the two fractions had specific effects. Fraction II shifted the voltage dependence of Na+ current activation by -42 mV, and the voltage dependence of Na+ inactivation by -25 mV in the absence of a conditioning depolarizing pre-pulse. Slowing of Na+ inactivation was most prominent at negative membrane potentials, resulting in a steady Na+ inward current at the holding potential of -80 mV. Fraction III induced a pronounced slowing of Na+ inactivation leading to an increase of peak Na+ currents and to incomplete steady state Na+ inactivation even at positive membrane potentials.",

author = "Bauer, {Christiane K.} and B Krylov and Zhou, {P A} and Schwarz, {J R}",

year = "1992",

doi = "10.1016/0041-0101(92)90852-v",

language = "Deutsch",

volume = "30",

pages = "581--589",

journal = "TOXICON",

issn = "0041-0101",

publisher = "Elsevier Limited",

number = "5-6",

}

RIS

TY - JOUR

T1 - Effects of Buthus martensii (Karsch) scorpion venom on sodium currents in rat anterior pituitary (GH3/B6) cells.

AU - Bauer, Christiane K.

AU - Krylov, B

AU - Zhou, P A

AU - Schwarz, J R

PY - 1992

Y1 - 1992

N2 - The effects of two fractions (II, containing anti-insect toxins, and III, containing eight anti-mammal toxins) isolated from the venom of the Old World scorpion Buthus martensii (Karsch) on Na+ currents of rat anterior pituitary cells (GH3/B6 cells) were investigated using the whole-cell configuration of the patch clamp technique. Fraction II induced a temporary, and fraction III a permanent increase of the Na+ current amplitude. Application of each of the venom fractions resulted in a flattening of the curve relating steady state Na+ inactivation to membrane potential. In addition, the two fractions had specific effects. Fraction II shifted the voltage dependence of Na+ current activation by -42 mV, and the voltage dependence of Na+ inactivation by -25 mV in the absence of a conditioning depolarizing pre-pulse. Slowing of Na+ inactivation was most prominent at negative membrane potentials, resulting in a steady Na+ inward current at the holding potential of -80 mV. Fraction III induced a pronounced slowing of Na+ inactivation leading to an increase of peak Na+ currents and to incomplete steady state Na+ inactivation even at positive membrane potentials.

AB - The effects of two fractions (II, containing anti-insect toxins, and III, containing eight anti-mammal toxins) isolated from the venom of the Old World scorpion Buthus martensii (Karsch) on Na+ currents of rat anterior pituitary cells (GH3/B6 cells) were investigated using the whole-cell configuration of the patch clamp technique. Fraction II induced a temporary, and fraction III a permanent increase of the Na+ current amplitude. Application of each of the venom fractions resulted in a flattening of the curve relating steady state Na+ inactivation to membrane potential. In addition, the two fractions had specific effects. Fraction II shifted the voltage dependence of Na+ current activation by -42 mV, and the voltage dependence of Na+ inactivation by -25 mV in the absence of a conditioning depolarizing pre-pulse. Slowing of Na+ inactivation was most prominent at negative membrane potentials, resulting in a steady Na+ inward current at the holding potential of -80 mV. Fraction III induced a pronounced slowing of Na+ inactivation leading to an increase of peak Na+ currents and to incomplete steady state Na+ inactivation even at positive membrane potentials.

U2 - 10.1016/0041-0101(92)90852-v

DO - 10.1016/0041-0101(92)90852-v

M3 - SCORING: Zeitschriftenaufsatz

VL - 30

SP - 581

EP - 589

JO - TOXICON

JF - TOXICON

SN - 0041-0101

IS - 5-6

M1 - 5-6

ER -