Effects of atrial fibrillation and heart rate on percutaneous mitral valve repair with MitraClip: results from the TRAnscatheter Mitral valve Interventions (TRAMI) registry
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Effects of atrial fibrillation and heart rate on percutaneous mitral valve repair with MitraClip: results from the TRAnscatheter Mitral valve Interventions (TRAMI) registry. / Jabs, Alexander; von Bardeleben, Ralph S; Boekstegers, Peter; Puls, Miriam; Lubos, Edith; Bekeredjian, Raffi; Ouarrak, Taoufik; Plicht, Björn; Eggebrecht, Holger; Nickenig, Georg; Butter, Christian; Hoffmann, Rainer; Senges, Jochen; Hink, Ulrich.
in: EUROINTERVENTION, Jahrgang 12, Nr. 14, 20.02.2017, S. 1697-1705.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Effects of atrial fibrillation and heart rate on percutaneous mitral valve repair with MitraClip: results from the TRAnscatheter Mitral valve Interventions (TRAMI) registry
AU - Jabs, Alexander
AU - von Bardeleben, Ralph S
AU - Boekstegers, Peter
AU - Puls, Miriam
AU - Lubos, Edith
AU - Bekeredjian, Raffi
AU - Ouarrak, Taoufik
AU - Plicht, Björn
AU - Eggebrecht, Holger
AU - Nickenig, Georg
AU - Butter, Christian
AU - Hoffmann, Rainer
AU - Senges, Jochen
AU - Hink, Ulrich
PY - 2017/2/20
Y1 - 2017/2/20
N2 - AIMS: In patients undergoing percutaneous edge-to-edge mitral valve repair for mitral valve regurgitation (MR), our aim was to evaluate acute and follow-up differences with pre-existing sinus rhythm (SR) or atrial fibrillation (AF), as well as comparisons stratified by baseline heart rate.METHODS AND RESULTS: Seven hundred and sixty patients who underwent a MitraClip procedure were prospectively enrolled in the TRAnscatheter Mitral valve Interventions (TRAMI) registry, and stratified according to baseline heart rhythm and heart rate with a cut-off value of 70 beats per minute. Technical success, procedural characteristics and MR reduction were similar throughout the subgroups. Overall, in-hospital adverse event rates were low in this high-risk patient collective. At 12 months, survival was higher in SR (83.5%) than AF patients (74.9%, p<0.05), while the cumulative major adverse cardio-cerebrovascular event rate did not differ, and a sustained improvement of NYHA functional class occurred in all subgroups.CONCLUSIONS: These registry data, comprising the largest number of unselected "real-world" MitraClip patients, suggest that the intervention can be performed safely and effectively, and reduces MR in the majority of patients irrespective of baseline rhythm or heart rate. While 12-month survival was higher for patients with SR, overall MACCE and clinical improvement did not differ between the subgroups.
AB - AIMS: In patients undergoing percutaneous edge-to-edge mitral valve repair for mitral valve regurgitation (MR), our aim was to evaluate acute and follow-up differences with pre-existing sinus rhythm (SR) or atrial fibrillation (AF), as well as comparisons stratified by baseline heart rate.METHODS AND RESULTS: Seven hundred and sixty patients who underwent a MitraClip procedure were prospectively enrolled in the TRAnscatheter Mitral valve Interventions (TRAMI) registry, and stratified according to baseline heart rhythm and heart rate with a cut-off value of 70 beats per minute. Technical success, procedural characteristics and MR reduction were similar throughout the subgroups. Overall, in-hospital adverse event rates were low in this high-risk patient collective. At 12 months, survival was higher in SR (83.5%) than AF patients (74.9%, p<0.05), while the cumulative major adverse cardio-cerebrovascular event rate did not differ, and a sustained improvement of NYHA functional class occurred in all subgroups.CONCLUSIONS: These registry data, comprising the largest number of unselected "real-world" MitraClip patients, suggest that the intervention can be performed safely and effectively, and reduces MR in the majority of patients irrespective of baseline rhythm or heart rate. While 12-month survival was higher for patients with SR, overall MACCE and clinical improvement did not differ between the subgroups.
KW - Aged
KW - Aged, 80 and over
KW - Atrial Fibrillation/physiopathology
KW - Cardiac Catheterization/adverse effects
KW - Female
KW - Heart Rate/physiology
KW - Heart Valve Prosthesis/adverse effects
KW - Heart Valve Prosthesis Implantation/methods
KW - Humans
KW - Male
KW - Mitral Valve/physiopathology
KW - Mitral Valve Insufficiency/physiopathology
KW - Postoperative Complications/physiopathology
KW - Registries
KW - Treatment Outcome
U2 - 10.4244/EIJ-D-16-00115
DO - 10.4244/EIJ-D-16-00115
M3 - SCORING: Journal article
C2 - 28216472
VL - 12
SP - 1697
EP - 1705
JO - EUROINTERVENTION
JF - EUROINTERVENTION
SN - 1774-024X
IS - 14
ER -