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Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)

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Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). / Rodriguez, Francisca S; Röhr, Susanne; Pabst, Alexander; Kleineidam, Luca; Fuchs, Angela; Wiese, Birgitt; Lühmann, Dagmar; Brettschneider, Christian; Wolfsgruber, Steffen; Pentzek, Michael; Bussche van den, Hendrik; König, Hans-Helmut; Weyerer, Siegfried; Werle, Jochen; Bickel, Horst; Weeg, Dagmar; Maier, Wolfgang; Scherer, Martin; Wagner, M.; Riedel-Heller, Steffi.

in: INT J GERIATR PSYCH, Jahrgang 36, Nr. 1, 01.2021, S. 152-162.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Rodriguez, FS, Röhr, S, Pabst, A, Kleineidam, L, Fuchs, A, Wiese, B, Lühmann, D, Brettschneider, C, Wolfsgruber, S, Pentzek, M, Bussche van den, H, König, H-H, Weyerer, S, Werle, J, Bickel, H, Weeg, D, Maier, W, Scherer, M, Wagner, M & Riedel-Heller, S 2021, 'Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)', INT J GERIATR PSYCH, Jg. 36, Nr. 1, S. 152-162. https://doi.org/10.1002/gps.5409

APA

Rodriguez, F. S., Röhr, S., Pabst, A., Kleineidam, L., Fuchs, A., Wiese, B., Lühmann, D., Brettschneider, C., Wolfsgruber, S., Pentzek, M., Bussche van den, H., König, H-H., Weyerer, S., Werle, J., Bickel, H., Weeg, D., Maier, W., Scherer, M., Wagner, M., & Riedel-Heller, S. (2021). Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). INT J GERIATR PSYCH, 36(1), 152-162. https://doi.org/10.1002/gps.5409

Vancouver

Rodriguez FS, Röhr S, Pabst A, Kleineidam L, Fuchs A, Wiese B et al. Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe). INT J GERIATR PSYCH. 2021 Jan;36(1):152-162. https://doi.org/10.1002/gps.5409

Bibtex

@article{90f8bc735b9a49e08df0358099b3fc9b,
title = "Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)",
abstract = "ObjectivesPrevious studies have observed protective effects of high mental demands at work on cognitive functioning and dementia risk. However, it is unclear what types of demands drive this effect and whether this effect is subject to a person's genetic risk. We investigated to what extent eight different types of mental demands at work together with the APOE e4 allele, a major risk gene for late-onset Alzheimer's disease, affect cognitive functioning in late life.Methods/DesignThe population-based German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe, n = 2 154) followed cognitively healthy individuals aged 75 years and older in seven assessment waves. Cognitive functioning was assessed via the mini-mental status examination.ResultsMixed-effects modeling (adjusted for education, gender, marital status, stroke, depression, and diabetes) indicated that participants who had an occupational history of working in jobs with high compared to low demands in “Language & Knowledge”, “Pattern detection”, “Information processing”, and “Service” had a slower cognitive decline. APOE e4-allele carriers had an accelerated cognitive decline, but this decline was significantly smaller if they had a medium compared to a low level of demands in contrast to non-carriers.ConclusionsOur longitudinal observations suggest that cognitive decline could be slowed by an intellectually enriched lifestyle even in risk gene carriers. Fostering intellectual engagement throughout the life-course could be a key prevention initiative to promote better cognitive health in old age.",
author = "Rodriguez, {Francisca S} and Susanne R{\"o}hr and Alexander Pabst and Luca Kleineidam and Angela Fuchs and Birgitt Wiese and Dagmar L{\"u}hmann and Christian Brettschneider and Steffen Wolfsgruber and Michael Pentzek and {Bussche van den}, Hendrik and Hans-Helmut K{\"o}nig and Siegfried Weyerer and Jochen Werle and Horst Bickel and Dagmar Weeg and Wolfgang Maier and Martin Scherer and M. Wagner and Steffi Riedel-Heller",
year = "2021",
month = jan,
doi = "10.1002/gps.5409",
language = "English",
volume = "36",
pages = "152--162",
journal = "INT J GERIATR PSYCH",
issn = "0885-6230",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Effects of APOE e4-allele and mental work demands on cognitive decline in old age: Results from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe)

AU - Rodriguez, Francisca S

AU - Röhr, Susanne

AU - Pabst, Alexander

AU - Kleineidam, Luca

AU - Fuchs, Angela

AU - Wiese, Birgitt

AU - Lühmann, Dagmar

AU - Brettschneider, Christian

AU - Wolfsgruber, Steffen

AU - Pentzek, Michael

AU - Bussche van den, Hendrik

AU - König, Hans-Helmut

AU - Weyerer, Siegfried

AU - Werle, Jochen

AU - Bickel, Horst

AU - Weeg, Dagmar

AU - Maier, Wolfgang

AU - Scherer, Martin

AU - Wagner, M.

AU - Riedel-Heller, Steffi

PY - 2021/1

Y1 - 2021/1

N2 - ObjectivesPrevious studies have observed protective effects of high mental demands at work on cognitive functioning and dementia risk. However, it is unclear what types of demands drive this effect and whether this effect is subject to a person's genetic risk. We investigated to what extent eight different types of mental demands at work together with the APOE e4 allele, a major risk gene for late-onset Alzheimer's disease, affect cognitive functioning in late life.Methods/DesignThe population-based German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe, n = 2 154) followed cognitively healthy individuals aged 75 years and older in seven assessment waves. Cognitive functioning was assessed via the mini-mental status examination.ResultsMixed-effects modeling (adjusted for education, gender, marital status, stroke, depression, and diabetes) indicated that participants who had an occupational history of working in jobs with high compared to low demands in “Language & Knowledge”, “Pattern detection”, “Information processing”, and “Service” had a slower cognitive decline. APOE e4-allele carriers had an accelerated cognitive decline, but this decline was significantly smaller if they had a medium compared to a low level of demands in contrast to non-carriers.ConclusionsOur longitudinal observations suggest that cognitive decline could be slowed by an intellectually enriched lifestyle even in risk gene carriers. Fostering intellectual engagement throughout the life-course could be a key prevention initiative to promote better cognitive health in old age.

AB - ObjectivesPrevious studies have observed protective effects of high mental demands at work on cognitive functioning and dementia risk. However, it is unclear what types of demands drive this effect and whether this effect is subject to a person's genetic risk. We investigated to what extent eight different types of mental demands at work together with the APOE e4 allele, a major risk gene for late-onset Alzheimer's disease, affect cognitive functioning in late life.Methods/DesignThe population-based German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe, n = 2 154) followed cognitively healthy individuals aged 75 years and older in seven assessment waves. Cognitive functioning was assessed via the mini-mental status examination.ResultsMixed-effects modeling (adjusted for education, gender, marital status, stroke, depression, and diabetes) indicated that participants who had an occupational history of working in jobs with high compared to low demands in “Language & Knowledge”, “Pattern detection”, “Information processing”, and “Service” had a slower cognitive decline. APOE e4-allele carriers had an accelerated cognitive decline, but this decline was significantly smaller if they had a medium compared to a low level of demands in contrast to non-carriers.ConclusionsOur longitudinal observations suggest that cognitive decline could be slowed by an intellectually enriched lifestyle even in risk gene carriers. Fostering intellectual engagement throughout the life-course could be a key prevention initiative to promote better cognitive health in old age.

U2 - 10.1002/gps.5409

DO - 10.1002/gps.5409

M3 - SCORING: Journal article

VL - 36

SP - 152

EP - 162

JO - INT J GERIATR PSYCH

JF - INT J GERIATR PSYCH

SN - 0885-6230

IS - 1

ER -