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Effects of anti-glaucoma medications on ganglion cell survival

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Effects of anti-glaucoma medications on ganglion cell survival : the DBA/2J mouse model. / Schuettauf, Frank; Quinto, Kristine; Naskar, Rita; Zurakowski, David.

in: VISION RES, Jahrgang 42, Nr. 20, 09.2002, S. 2333-7.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Schuettauf, F, Quinto, K, Naskar, R & Zurakowski, D 2002, 'Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model', VISION RES, Jg. 42, Nr. 20, S. 2333-7. https://doi.org/10.1016/s0042-6989(02)00188-8

APA

Schuettauf, F., Quinto, K., Naskar, R., & Zurakowski, D. (2002). Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model. VISION RES, 42(20), 2333-7. https://doi.org/10.1016/s0042-6989(02)00188-8

Vancouver

Schuettauf F, Quinto K, Naskar R, Zurakowski D. Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model. VISION RES. 2002 Sep;42(20):2333-7. https://doi.org/10.1016/s0042-6989(02)00188-8

Bibtex

@article{15f892a5ac304a339c64e02f9127d5a7,
title = "Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model",
abstract = "We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in preventing ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labeled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (P<0.0001, analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension.",
keywords = "Aging/pathology, Analysis of Variance, Animals, Antihypertensive Agents/pharmacology, Brimonidine Tartrate, Cell Survival/drug effects, Disease Models, Animal, Glaucoma/drug therapy, Memantine/pharmacology, Mice, Mice, Inbred DBA, Quinoxalines/pharmacology, Retinal Ganglion Cells/drug effects, Timolol/pharmacology",
author = "Frank Schuettauf and Kristine Quinto and Rita Naskar and David Zurakowski",
year = "2002",
month = sep,
doi = "10.1016/s0042-6989(02)00188-8",
language = "English",
volume = "42",
pages = "2333--7",
journal = "VISION RES",
issn = "0042-6989",
publisher = "Elsevier Limited",
number = "20",

}

RIS

TY - JOUR

T1 - Effects of anti-glaucoma medications on ganglion cell survival

T2 - the DBA/2J mouse model

AU - Schuettauf, Frank

AU - Quinto, Kristine

AU - Naskar, Rita

AU - Zurakowski, David

PY - 2002/9

Y1 - 2002/9

N2 - We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in preventing ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labeled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (P<0.0001, analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension.

AB - We studied whether several agents, approved or undergoing trials in human glaucoma, were effective in preventing ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labeled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (P<0.0001, analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension.

KW - Aging/pathology

KW - Analysis of Variance

KW - Animals

KW - Antihypertensive Agents/pharmacology

KW - Brimonidine Tartrate

KW - Cell Survival/drug effects

KW - Disease Models, Animal

KW - Glaucoma/drug therapy

KW - Memantine/pharmacology

KW - Mice

KW - Mice, Inbred DBA

KW - Quinoxalines/pharmacology

KW - Retinal Ganglion Cells/drug effects

KW - Timolol/pharmacology

U2 - 10.1016/s0042-6989(02)00188-8

DO - 10.1016/s0042-6989(02)00188-8

M3 - SCORING: Journal article

C2 - 12350421

VL - 42

SP - 2333

EP - 2337

JO - VISION RES

JF - VISION RES

SN - 0042-6989

IS - 20

ER -