Effectiveness of transcranial direct current stimulation preceding cognitive behavioural management for chronic low back pain: sham controlled double blinded randomised controlled trial
Standard
Effectiveness of transcranial direct current stimulation preceding cognitive behavioural management for chronic low back pain: sham controlled double blinded randomised controlled trial. / Lüdtke, Kerstin; Rushton, Alison; Wright, Christine; Jürgens, Tim; Polzer, Astrid; Mueller, Gerd; May, Arne.
in: BMJ-BRIT MED J, Jahrgang 350, 16.04.2015, S. h1640.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Effectiveness of transcranial direct current stimulation preceding cognitive behavioural management for chronic low back pain: sham controlled double blinded randomised controlled trial
AU - Lüdtke, Kerstin
AU - Rushton, Alison
AU - Wright, Christine
AU - Jürgens, Tim
AU - Polzer, Astrid
AU - Mueller, Gerd
AU - May, Arne
N1 - © Luedtke et al 2015.
PY - 2015/4/16
Y1 - 2015/4/16
N2 - OBJECTIVE: To evaluate the effectiveness of transcranial direct current stimulation alone and in combination with cognitive behavioural management in patients with non-specific chronic low back pain.DESIGN: Double blind parallel group randomised controlled trial with six months' follow-up conducted May 2011-March 2013. Participants, physiotherapists, assessors, and analyses were blinded to group allocation.SETTING: Interdisciplinary chronic pain centre.PARTICIPANTS: 135 participants with non-specific chronic low back pain >12 weeks were recruited from 225 patients assessed for eligibility.INTERVENTION: Participants were randomised to receive anodal (20 minutes to motor cortex at 2 mA) or sham transcranial direct current stimulation (identical electrode position, stimulator switched off after 30 seconds) for five consecutive days immediately before cognitive behavioural management (four week multidisciplinary programme of 80 hours).MAIN OUTCOMES MEASURES: Two primary outcome measures of pain intensity (0-100 visual analogue scale) and disability (Oswestry disability index) were evaluated at two primary endpoints after stimulation and after cognitive behavioural management.RESULTS: Analyses of covariance with baseline values (pain or disability) as covariates showed that transcranial direct current stimulation was ineffective for the reduction of pain (difference between groups on visual analogue scale 1 mm (99% confidence interval -8.69 mm to 6.3 mm; P=0.68)) and disability (difference between groups 1 point (-1.73 to 1.98; P=0.86)) and did not influence the outcome of cognitive behavioural management (difference between group 3 mm (-10.32 mm to 6.73 mm); P=0.58; difference between groups on Oswestry disability index 0 point (-2.45 to 2.62); P=0.92). The stimulation was well tolerated with minimal transitory side effects.CONCLUSIONS: This results of this trial on the effectiveness of transcranial direct current stimulation for the reduction of pain and disability do not support its clinical use for managing non-specific chronic low back pain.Trial registration Current controlled trials ISRCTN89874874.
AB - OBJECTIVE: To evaluate the effectiveness of transcranial direct current stimulation alone and in combination with cognitive behavioural management in patients with non-specific chronic low back pain.DESIGN: Double blind parallel group randomised controlled trial with six months' follow-up conducted May 2011-March 2013. Participants, physiotherapists, assessors, and analyses were blinded to group allocation.SETTING: Interdisciplinary chronic pain centre.PARTICIPANTS: 135 participants with non-specific chronic low back pain >12 weeks were recruited from 225 patients assessed for eligibility.INTERVENTION: Participants were randomised to receive anodal (20 minutes to motor cortex at 2 mA) or sham transcranial direct current stimulation (identical electrode position, stimulator switched off after 30 seconds) for five consecutive days immediately before cognitive behavioural management (four week multidisciplinary programme of 80 hours).MAIN OUTCOMES MEASURES: Two primary outcome measures of pain intensity (0-100 visual analogue scale) and disability (Oswestry disability index) were evaluated at two primary endpoints after stimulation and after cognitive behavioural management.RESULTS: Analyses of covariance with baseline values (pain or disability) as covariates showed that transcranial direct current stimulation was ineffective for the reduction of pain (difference between groups on visual analogue scale 1 mm (99% confidence interval -8.69 mm to 6.3 mm; P=0.68)) and disability (difference between groups 1 point (-1.73 to 1.98; P=0.86)) and did not influence the outcome of cognitive behavioural management (difference between group 3 mm (-10.32 mm to 6.73 mm); P=0.58; difference between groups on Oswestry disability index 0 point (-2.45 to 2.62); P=0.92). The stimulation was well tolerated with minimal transitory side effects.CONCLUSIONS: This results of this trial on the effectiveness of transcranial direct current stimulation for the reduction of pain and disability do not support its clinical use for managing non-specific chronic low back pain.Trial registration Current controlled trials ISRCTN89874874.
KW - Adolescent
KW - Adult
KW - Aged
KW - Chronic Pain
KW - Cognitive Therapy
KW - Combined Modality Therapy
KW - Disability Evaluation
KW - Double-Blind Method
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Low Back Pain
KW - Male
KW - Middle Aged
KW - Models, Statistical
KW - Pain Measurement
KW - Transcranial Direct Current Stimulation
KW - Treatment Outcome
KW - Young Adult
U2 - 10.1136/bmj.h1640
DO - 10.1136/bmj.h1640
M3 - SCORING: Journal article
C2 - 25883244
VL - 350
SP - h1640
JO - BMJ-BRIT MED J
JF - BMJ-BRIT MED J
SN - 0959-535X
ER -