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Effective Connectivity between Hippocampus and Ventromedial Prefrontal Cortex Controls Preferential Choices from Memory

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Effective Connectivity between Hippocampus and Ventromedial Prefrontal Cortex Controls Preferential Choices from Memory. / Gluth, Sebastian; Sommer-Blöchl, Tobias; Rieskamp, Jörg; Büchel, Christian.

in: NEURON, Jahrgang 86, Nr. 4, 20.05.2015, S. 1078-90.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Gluth, S, Sommer-Blöchl, T, Rieskamp, J & Büchel, C 2015, 'Effective Connectivity between Hippocampus and Ventromedial Prefrontal Cortex Controls Preferential Choices from Memory', NEURON, Jg. 86, Nr. 4, S. 1078-90. https://doi.org/10.1016/j.neuron.2015.04.023

APA

Gluth, S., Sommer-Blöchl, T., Rieskamp, J., & Büchel, C. (2015). Effective Connectivity between Hippocampus and Ventromedial Prefrontal Cortex Controls Preferential Choices from Memory. NEURON, 86(4), 1078-90. https://doi.org/10.1016/j.neuron.2015.04.023

Vancouver

Gluth S, Sommer-Blöchl T, Rieskamp J, Büchel C. Effective Connectivity between Hippocampus and Ventromedial Prefrontal Cortex Controls Preferential Choices from Memory. NEURON. 2015 Mai 20;86(4):1078-90. https://doi.org/10.1016/j.neuron.2015.04.023

Bibtex

@article{c32698ae2ae648689335de66b6b8127a,
title = "Effective Connectivity between Hippocampus and Ventromedial Prefrontal Cortex Controls Preferential Choices from Memory",
abstract = "Although many preferential choices in everyday life require remembering relevant information, the interplay of neural systems mediating decisions and memory has rarely been studied. We addressed this question by combining a task, in which choice options had to be retrieved from memory, with cognitive modeling and fMRI. We found that memory-guided decisions are captured by established process models of choice (sequential sampling models) but constrained by forgetting. People are biased toward remembered options and reject them only if they are very unattractive. Using a Bayesian modeling approach, we determined the posterior probability that options were remembered given the observed choices. This probability correlated with hippocampal activation during encoding. During decision making, the bias toward remembered options was linked to increased connectivity between hippocampus and ventromedial prefrontal cortex. Our results provide insights into the dependency of decisions on memory constraints and show that memory-related activation can be inferred from decisions.",
keywords = "Adolescent, Adult, Brain Mapping, Choice Behavior, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Memory, Neural Pathways, Prefrontal Cortex, Young Adult",
author = "Sebastian Gluth and Tobias Sommer-Bl{\"o}chl and J{\"o}rg Rieskamp and Christian B{\"u}chel",
note = "Copyright {\textcopyright} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = may,
day = "20",
doi = "10.1016/j.neuron.2015.04.023",
language = "English",
volume = "86",
pages = "1078--90",
journal = "NEURON",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Effective Connectivity between Hippocampus and Ventromedial Prefrontal Cortex Controls Preferential Choices from Memory

AU - Gluth, Sebastian

AU - Sommer-Blöchl, Tobias

AU - Rieskamp, Jörg

AU - Büchel, Christian

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/5/20

Y1 - 2015/5/20

N2 - Although many preferential choices in everyday life require remembering relevant information, the interplay of neural systems mediating decisions and memory has rarely been studied. We addressed this question by combining a task, in which choice options had to be retrieved from memory, with cognitive modeling and fMRI. We found that memory-guided decisions are captured by established process models of choice (sequential sampling models) but constrained by forgetting. People are biased toward remembered options and reject them only if they are very unattractive. Using a Bayesian modeling approach, we determined the posterior probability that options were remembered given the observed choices. This probability correlated with hippocampal activation during encoding. During decision making, the bias toward remembered options was linked to increased connectivity between hippocampus and ventromedial prefrontal cortex. Our results provide insights into the dependency of decisions on memory constraints and show that memory-related activation can be inferred from decisions.

AB - Although many preferential choices in everyday life require remembering relevant information, the interplay of neural systems mediating decisions and memory has rarely been studied. We addressed this question by combining a task, in which choice options had to be retrieved from memory, with cognitive modeling and fMRI. We found that memory-guided decisions are captured by established process models of choice (sequential sampling models) but constrained by forgetting. People are biased toward remembered options and reject them only if they are very unattractive. Using a Bayesian modeling approach, we determined the posterior probability that options were remembered given the observed choices. This probability correlated with hippocampal activation during encoding. During decision making, the bias toward remembered options was linked to increased connectivity between hippocampus and ventromedial prefrontal cortex. Our results provide insights into the dependency of decisions on memory constraints and show that memory-related activation can be inferred from decisions.

KW - Adolescent

KW - Adult

KW - Brain Mapping

KW - Choice Behavior

KW - Female

KW - Hippocampus

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory

KW - Neural Pathways

KW - Prefrontal Cortex

KW - Young Adult

U2 - 10.1016/j.neuron.2015.04.023

DO - 10.1016/j.neuron.2015.04.023

M3 - SCORING: Journal article

C2 - 25996135

VL - 86

SP - 1078

EP - 1090

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 4

ER -