Effect of personalized perioperative blood pressure management on postoperative complications and mortality in high-risk patients having major abdominal surgery: protocol for a multicenter randomized trial (IMPROVE-multi)
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Effect of personalized perioperative blood pressure management on postoperative complications and mortality in high-risk patients having major abdominal surgery: protocol for a multicenter randomized trial (IMPROVE-multi). / Bergholz, Alina; Meidert, Agnes S; Flick, Moritz; Krause, Linda; Vettorazzi, Eik; Zapf, Antonia; Brunkhorst, Frank M; Meybohm, Patrick; Zacharowski, Kai; Zarbock, Alexander; Sessler, Daniel I; Kouz, Karim; Saugel, Bernd.
in: TRIALS, Jahrgang 23, Nr. 1, 17.11.2022, S. 946.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Effect of personalized perioperative blood pressure management on postoperative complications and mortality in high-risk patients having major abdominal surgery: protocol for a multicenter randomized trial (IMPROVE-multi)
AU - Bergholz, Alina
AU - Meidert, Agnes S
AU - Flick, Moritz
AU - Krause, Linda
AU - Vettorazzi, Eik
AU - Zapf, Antonia
AU - Brunkhorst, Frank M
AU - Meybohm, Patrick
AU - Zacharowski, Kai
AU - Zarbock, Alexander
AU - Sessler, Daniel I
AU - Kouz, Karim
AU - Saugel, Bernd
N1 - © 2022. The Author(s).
PY - 2022/11/17
Y1 - 2022/11/17
N2 - BACKGROUND: Intraoperative hypotension is common in patients having non-cardiac surgery and is associated with serious complications and death. However, optimal intraoperative blood pressures for individual patients remain unknown. We therefore aim to test the hypothesis that personalized perioperative blood pressure management-based on preoperative automated blood pressure monitoring-reduces the incidence of a composite outcome of acute kidney injury, acute myocardial injury, non-fatal cardiac arrest, and death within 7 days after surgery compared to routine blood pressure management in high-risk patients having major abdominal surgery.METHODS: IMPROVE-multi is a multicenter randomized trial in 1272 high-risk patients having elective major abdominal surgery that we plan to conduct at 16 German university medical centers. Preoperative automated blood pressure monitoring using upper arm cuff oscillometry will be performed in all patients for one night to obtain the mean of the nighttime mean arterial pressures. Patients will then be randomized either to personalized blood pressure management or to routine blood pressure management. In patients assigned to personalized management, intraoperative mean arterial pressure will be maintained at least at the mean of the nighttime mean arterial pressures. In patients assigned to routine management, intraoperative blood pressure will be managed per routine. The primary outcome will be a composite of acute kidney injury, acute myocardial injury, non-fatal cardiac arrest, and death within 7 days after surgery.DISCUSSION: Our trial will determine whether personalized perioperative blood pressure management reduces the incidence of major postoperative complications and death within 7 days after surgery compared to routine blood pressure management in high-risk patients having major abdominal surgery.TRIAL REGISTRATION: ClinicalTrials.gov NCT05416944. Registered on June 14, 2022.
AB - BACKGROUND: Intraoperative hypotension is common in patients having non-cardiac surgery and is associated with serious complications and death. However, optimal intraoperative blood pressures for individual patients remain unknown. We therefore aim to test the hypothesis that personalized perioperative blood pressure management-based on preoperative automated blood pressure monitoring-reduces the incidence of a composite outcome of acute kidney injury, acute myocardial injury, non-fatal cardiac arrest, and death within 7 days after surgery compared to routine blood pressure management in high-risk patients having major abdominal surgery.METHODS: IMPROVE-multi is a multicenter randomized trial in 1272 high-risk patients having elective major abdominal surgery that we plan to conduct at 16 German university medical centers. Preoperative automated blood pressure monitoring using upper arm cuff oscillometry will be performed in all patients for one night to obtain the mean of the nighttime mean arterial pressures. Patients will then be randomized either to personalized blood pressure management or to routine blood pressure management. In patients assigned to personalized management, intraoperative mean arterial pressure will be maintained at least at the mean of the nighttime mean arterial pressures. In patients assigned to routine management, intraoperative blood pressure will be managed per routine. The primary outcome will be a composite of acute kidney injury, acute myocardial injury, non-fatal cardiac arrest, and death within 7 days after surgery.DISCUSSION: Our trial will determine whether personalized perioperative blood pressure management reduces the incidence of major postoperative complications and death within 7 days after surgery compared to routine blood pressure management in high-risk patients having major abdominal surgery.TRIAL REGISTRATION: ClinicalTrials.gov NCT05416944. Registered on June 14, 2022.
KW - Humans
KW - Blood Pressure
KW - Abdomen/surgery
KW - Postoperative Complications/etiology
KW - Acute Kidney Injury/complications
KW - Heart Arrest
KW - Randomized Controlled Trials as Topic
KW - Multicenter Studies as Topic
U2 - 10.1186/s13063-022-06854-0
DO - 10.1186/s13063-022-06854-0
M3 - SCORING: Journal article
C2 - 36397173
VL - 23
SP - 946
JO - TRIALS
JF - TRIALS
SN - 1745-6215
IS - 1
ER -
