Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum.

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Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. / Troeger, Hanno; Epple, Hans-Joerg; Schneider, Thomas; Wahnschaffe, Ulrich; Ullrich, Reiner; Burchard, Gerd-Dieter; Jelinek, Tomas; Zeitz, Martin; Fromm, Michael; Schulzke, Joerg-Dieter.

in: GUT, Jahrgang 56, Nr. 3, 3, 2007, S. 328-335.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

Harvard

Troeger, H, Epple, H-J, Schneider, T, Wahnschaffe, U, Ullrich, R, Burchard, G-D, Jelinek, T, Zeitz, M, Fromm, M & Schulzke, J-D 2007, 'Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum.', GUT, Jg. 56, Nr. 3, 3, S. 328-335. <http://www.ncbi.nlm.nih.gov/pubmed/16935925?dopt=Citation>

APA

Troeger, H., Epple, H-J., Schneider, T., Wahnschaffe, U., Ullrich, R., Burchard, G-D., Jelinek, T., Zeitz, M., Fromm, M., & Schulzke, J-D. (2007). Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. GUT, 56(3), 328-335. [3]. http://www.ncbi.nlm.nih.gov/pubmed/16935925?dopt=Citation

Vancouver

Troeger H, Epple H-J, Schneider T, Wahnschaffe U, Ullrich R, Burchard G-D et al. Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum. GUT. 2007;56(3):328-335. 3.

Bibtex

@article{612ca506e9ce4a7bbe4aed88d8cac163,
title = "Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum.",
abstract = "BACKGROUND: Giardia lamblia causes infection of the small intestine, which leads to malabsorption and chronic diarrhoea. AIM: To characterise the inherent pathomechanisms of G lamblia infection. METHODS: Duodenal biopsy specimens from 13 patients with chronic giardiasis and from controls were obtained endoscopically. Short-circuit current (I(SC)) and mannitol fluxes were measured in miniaturised Ussing chambers. Epithelial and subepithelial resistances were determined by impedance spectroscopy. Mucosal morphometry was performed and tight junction proteins were characterised by immunoblotting. Apoptotic ratio was determined by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelling staining. RESULTS: In giardiasis, mucosal surface area per unit serosa area was decreased to 75% (3%) of control, as a result of which epithelial resistance should increase. Instead, epithelial resistance of giardiasis biopsy specimens was decreased (19 (2) vs 25 (2) Omega cm(2); p",
author = "Hanno Troeger and Hans-Joerg Epple and Thomas Schneider and Ulrich Wahnschaffe and Reiner Ullrich and Gerd-Dieter Burchard and Tomas Jelinek and Martin Zeitz and Michael Fromm and Joerg-Dieter Schulzke",
year = "2007",
language = "Deutsch",
volume = "56",
pages = "328--335",
journal = "GUT",
issn = "0017-5749",
publisher = "BMJ PUBLISHING GROUP",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of chronic Giardia lamblia infection on epithelial transport and barrier function in human duodenum.

AU - Troeger, Hanno

AU - Epple, Hans-Joerg

AU - Schneider, Thomas

AU - Wahnschaffe, Ulrich

AU - Ullrich, Reiner

AU - Burchard, Gerd-Dieter

AU - Jelinek, Tomas

AU - Zeitz, Martin

AU - Fromm, Michael

AU - Schulzke, Joerg-Dieter

PY - 2007

Y1 - 2007

N2 - BACKGROUND: Giardia lamblia causes infection of the small intestine, which leads to malabsorption and chronic diarrhoea. AIM: To characterise the inherent pathomechanisms of G lamblia infection. METHODS: Duodenal biopsy specimens from 13 patients with chronic giardiasis and from controls were obtained endoscopically. Short-circuit current (I(SC)) and mannitol fluxes were measured in miniaturised Ussing chambers. Epithelial and subepithelial resistances were determined by impedance spectroscopy. Mucosal morphometry was performed and tight junction proteins were characterised by immunoblotting. Apoptotic ratio was determined by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelling staining. RESULTS: In giardiasis, mucosal surface area per unit serosa area was decreased to 75% (3%) of control, as a result of which epithelial resistance should increase. Instead, epithelial resistance of giardiasis biopsy specimens was decreased (19 (2) vs 25 (2) Omega cm(2); p

AB - BACKGROUND: Giardia lamblia causes infection of the small intestine, which leads to malabsorption and chronic diarrhoea. AIM: To characterise the inherent pathomechanisms of G lamblia infection. METHODS: Duodenal biopsy specimens from 13 patients with chronic giardiasis and from controls were obtained endoscopically. Short-circuit current (I(SC)) and mannitol fluxes were measured in miniaturised Ussing chambers. Epithelial and subepithelial resistances were determined by impedance spectroscopy. Mucosal morphometry was performed and tight junction proteins were characterised by immunoblotting. Apoptotic ratio was determined by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labelling staining. RESULTS: In giardiasis, mucosal surface area per unit serosa area was decreased to 75% (3%) of control, as a result of which epithelial resistance should increase. Instead, epithelial resistance of giardiasis biopsy specimens was decreased (19 (2) vs 25 (2) Omega cm(2); p

M3 - SCORING: Zeitschriftenaufsatz

VL - 56

SP - 328

EP - 335

JO - GUT

JF - GUT

SN - 0017-5749

IS - 3

M1 - 3

ER -